Gradient instability for ω < - 1

We show that in single scalar field models of the dark energy with equations of state satisfying w ≡ p/ρ < − 1, the effective Lagrangian for fluctuations about the homogeneous background has a wrong sign spatial kinetic term. In most cases, spatial gradients are ruled out by microwave background observations. The sign of w + 1 is not connected to the sign of the time derivative kinetic term in the effective Lagrangian

A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses

Background: Thoroughbred racehorses are subject to non-traumatic distal limb bone fractures that occur during racing and exercise. Susceptibility to fracture may be due to underlying disturbances in bone metabolism which have a genetic cause. Fracture risk has been shown to be heritable in several species but this study is the first genetic analysis of fracture risk in the horse. Results: Fracture cases (n = 269) were horses that sustained catastrophic distal limb fractures while racing on UK racecourses, necessitating euthanasia. Control horses (n = 253) were over 4 years of age, were racing during the same time period as the cases, and had no history of fracture at the time the study was carried out. The horses sampled were bred for both flat and National Hunt (NH) jump racing. 43,417 SNPs were employed to perform a genome-wide association analysis and to estimate the proportion of genetic variance attributable to the SNPs on each chromosome using restricted maximum likelihood (REML). Significant genetic variation associated with fracture risk was found on chromosomes 9, 18, 22 and 31. Three SNPs on chromosome 18 (62.05 Mb – 62.15 Mb) and one SNP on chromosome 1 (14.17 Mb) reached genome-wide significance (p &lt;0.05) in a genome-wide association study (GWAS). Two of the SNPs on ECA 18 were located in a haplotype block containing the gene zinc finger protein 804A (ZNF804A). One haplotype within this block has a protective effect (controls at 1.95 times less risk of fracture than cases, p = 1 × 10-4), while a second haplotype increases fracture risk (cases at 3.39 times higher risk of fracture than controls, p = 0.042). Conclusions: Fracture risk in the Thoroughbred horse is a complex condition with an underlying genetic basis. Multiple genomic regions contribute to susceptibility to fracture risk. This suggests there is the potential to develop SNP-based estimators for genetic risk of fracture in the Thoroughbred racehorse, using methods pioneered in livestock genetics such as genomic selection. This information would be useful to racehorse breeders and owners, enabling them to reduce the risk of injury in their horses

But a walking shadow: designing, performing and learning on the virtual stage

Representing elements of reality within a medium, or taking aspects from one medium and placing them in another is an act of remediation. The process of this act, however, is largely taken for granted. Despite the fact that available information enables a qualitative assessment of the history of multimedia and their influences on different fields of knowledge, there are still some areas that require more focused research attention. For example, the relationship between media evolution and new developments in scenographic practice is currently under investigation. This article explores the issue of immediacy as a condition of modern theatre in the context of digital reality. It discusses the opportunities and challenges that recent technologies present to contemporary practitioners and theatre design educators, creating a lot of scope to break with conventions. Here, we present two case studies that look into technology-mediated learning about scenography through the employment of novel computer visualization techniques. The first case study is concerned with new ways of researching and learning about theatre through creative exploration of design artefacts. The second case study investigates the role of the Immersive Virtual World Second Life™ (SL) in effective teaching of scenography, and in creating and experiencing theatrical performances

A High Power Hydrogen Target for Parity Violation Experiments

Parity-violating electron scattering measurements on hydrogen and deuterium, such as those underway at the Bates and CEBAF laboratories, require luminosities exceeding $10^{38}$cm$^{-2}$s$^{-1}$, resulting in large beam power deposition into cryogenic liquid. Such targets must be able to absorb 500 watts or more with minimal change in target density. A 40~cm long liquid hydrogen target, designed to absorb 500~watts of beam power without boiling, has been developed for the SAMPLE experiment at Bates. In recent tests with 40~$\mu$A of incident beam, no evidence was seen for density fluctuations in the target, at a sensitivity level of better than 1\%. A summary of the target design and operational experience will be presented.Comment: 13 pages, 9 postscript figure

There are no magnetically charged particle-like solutions of the Einstein Yang-Mills equations for Abelian models

We prove that there are no magnetically charged particle-like solutions for Abelian models in Einstein Yang-Mills, but for non-Abelian models the possibility remains open. An analysis of the Lie algebraic structure of the Yang-Mills fields is essential to our results. In one key step of our analysis we use invariant polynomials to determine which orbits of the gauge group contain the possible asymptotic Yang-Mills field configurations. Together with a new horizontal/vertical space decomposition of the Yang-Mills fields this enables us to overcome some obstacles and complete a dynamical system existence theorem for asymptotic solutions with nonzero total magnetic charge. We then prove that these solutions cannot be extended globally for Abelian models and begin an investigation of the details for non-Abelian models.Comment: 48 pages, 1 figur

Cosmic string parameter constraints and model analysis using small scale Cosmic Microwave Background data

We present a significant update of the constraints on the Abelian Higgs cosmic string tension by cosmic microwave background (CMB) data, enabled both by the use of new high-resolution CMB data from suborbital experiments as well as the latest results of the WMAP satellite, and by improved predictions for the impact of Abelian Higgs cosmic strings on the CMB power spectra. The new cosmic string spectra (presented in a previous work) were improved especially for small angular scales, through the use of larger Abelian Higgs string simulations and careful extrapolation. If Abelian Higgs strings are present then we find improved bounds on their contribution to the CMB anisotropies, f10< 0.095, and on their tension, G\mu< 0.57 x 10^-6, both at 95% confidence level using WMAP7 data; and f10 < 0.048 and G\mu < 0.42 x 10^-6 using all the CMB data. We also find that using all the CMB data, a scale invariant initial perturbation spectrum, ns=1, is now disfavoured at 2.4\sigma\ even if strings are present. A Bayesian model selection analysis no longer indicates a preference for strings.Comment: 8 pages, 3 figures; Minor corrections, matches published versio

Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients

Aims: Treatment with glucagon-like peptide (GLP)-1 receptor agonists or dipeptidyl peptidase (DPP)-4 inhibitors might increase gallstone formation; however, the mechanisms involved are unknown. We aimed to assess the effects of these drugs on gallbladder volume and bile acid profile. Materials and methods: A total of 57 type 2 diabetes patients (mean±SD age, 62.8±6.9years; BMI, 31.8±4.1kg/m2; HbA1c, 7.3%±0.6%), treated with metformin and/or sulfonylureas, were included in this 12-week randomized, placebo-controlled, double-blind, single-centre trial between July 2013 and August 2015 at the VU University Medical Center, the Netherlands. Patients received the GLP-1 receptor agonist liraglutide, the DPP-4 inhibitor sitagliptin or matching placebo for 12weeks. Gallbladder fasting volume and ejection fraction were measured using ultrasonography after a high-fat meal. Serum bile acids were measured in the fasting and postprandial state and in faecal samples. The trial was registered at ClinicalTrials.gov (NCT01744236). Results: Neither liraglutide nor sitagliptin had an effect on gallbladder fast

The Solution Space of the Unitary Matrix Model String Equation and the Sato Grassmannian

The space of all solutions to the string equation of the symmetric unitary one-matrix model is determined. It is shown that the string equation is equivalent to simple conditions on points $V_1$ and $V_2$ in the big cell \Gr of the Sato Grassmannian $Gr$. This is a consequence of a well-defined continuum limit in which the string equation has the simple form \lb \cp ,\cq_- \rb =\hbox{\rm 1}, with \cp and \cq_- $2\times 2$ matrices of differential operators. These conditions on $V_1$ and $V_2$ yield a simple system of first order differential equations whose analysis determines the space of all solutions to the string equation. This geometric formulation leads directly to the Virasoro constraints \L_n\,(n\geq 0), where \L_n annihilate the two modified-KdV \t-functions whose product gives the partition function of the Unitary Matrix Model.Comment: 21 page

WMAP constraints on inflationary models with global defects

We use the cosmic microwave background angular power spectra to place upper limits on the degree to which global defects may have aided cosmic structure formation. We explore this under the inflationary paradigm, but with the addition of textures resulting from the breaking of a global O(4) symmetry during the early stages of the Universe. As a measure of their contribution, we use the fraction of the temperature power spectrum that is attributed to the defects at a multipole of 10. However, we find a parameter degeneracy enabling a fit to the first-year WMAP data to be made even with a significant defect fraction. This degeneracy involves the baryon fraction and the Hubble constant, plus the normalization and tilt of the primordial power spectrum. Hence, constraints on these cosmological parameters are weakened. Combining the WMAP data with a constraint on the physical baryon fraction from big bang nucleosynthesis calculations and high-redshift deuterium abundance, limits the extent of the degeneracy and gives an upper bound on the defect fraction of 0.13 (95% confidence).Comment: 10pp LaTeX/RevTeX, 6 eps figs; matches accepted versio