391 research outputs found
The Distinction Between Economic Development and Economic Growth: Implications for North Carolina Development Policy
Two widely recognized economic theories attempt to explain the process of development in an interregional context. Trade theory (and traditional neoclassical growth theory in general) posits that economic growth is both the necessary and sufficient condition for development of a less developed region. The theory of unequal exchange, on the other hand, contends that while economic growth is necessary to the development of a region, it is not a sufficient condition to bring about true development, defined as increases in the overall welfare of the region's population. This article attempts to break down the determinants of wages into an economic growth component and an economic development component as suggested by these theories. It then shows the importance of the economic development component in explaining cross-state wage differentials. The state of North Carolina has attempted to further its development through growth-related policies. The analysis found herein suggests the need for a reassessment of North Carolina's existing development policies
GATA-1 deficiency rescues trabecular but not cortical bone in OPG deficient mice
GATA-1(low/low) mice have an increase in megakaryocytes (MKs) and trabecular bone. The latter is thought to result from MKs directly stimulating osteoblastic bone formation while simultaneously inhibiting osteoclastogenesis. Osteoprotegerin (OPG) is known to inhibit osteoclastogenesis and OPG(-/-) mice have reduced trabecular and cortical bone due to increased osteoclastogenesis. Interestingly, GATA-1(low/low) mice have increased OPG levels. Here, we sought to determine whether GATA-1 knockdown in OPG(-/-) mice could rescue the observed osteoporotic bone phenotype. GATA-1(low/low) mice were bred with OPG(-/-) mice and bone phenotype assessed. GATA-1(low/low) × OPG(-/-) mice have increased cortical bone porosity, similar to OPG(-/-) mice. Both OPG(-/-) and GATA-1(low/low) × OPG(-/-) mice, were found to have increased osteoclasts localized to cortical bone, possibly producing the observed elevated porosity. Biomechanical assessment indicates that OPG(-/-) and GATA-1(low/low) × OPG(-/-) femurs are weaker and less stiff than C57BL/6 or GATA-1(low/low) femurs. Notably, GATA-1(low/low) × OPG(-/-) mice had trabecular bone parameters that were not different from C57BL/6 values, suggesting that GATA-1 deficiency can partially rescue the trabecular bone loss observed with OPG deficiency. The fact that GATA-1 deficiency appears to be able to partially rescue the trabecular, but not the cortical bone phenotype suggests that MKs can locally enhance trabecular bone volume, but that MK secreted factors cannot access cortical bone sufficiently to inhibit osteoclastogenesis or that OPG itself is required to inhibit osteoclastogenesis in cortical bone
A High Fat Diet Increases Bone Marrow Adipose Tissue (MAT) But Does Not Alter Trabecular or Cortical Bone Mass in C57BL/6J Mice
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111767/1/jcp24954.pd
Perfect state distinguishability and computational speedups with postselected closed timelike curves
Bennett and Schumacher's postselected quantum teleportation is a model of
closed timelike curves (CTCs) that leads to results physically different from
Deutsch's model. We show that even a single qubit passing through a
postselected CTC (P-CTC) is sufficient to do any postselected quantum
measurement, and we discuss an important difference between "Deutschian" CTCs
(D-CTCs) and P-CTCs in which the future existence of a P-CTC might affect the
present outcome of an experiment. Then, based on a suggestion of Bennett and
Smith, we explicitly show how a party assisted by P-CTCs can distinguish a set
of linearly independent quantum states, and we prove that it is not possible
for such a party to distinguish a set of linearly dependent states. The power
of P-CTCs is thus weaker than that of D-CTCs because the Holevo bound still
applies to circuits using them regardless of their ability to conspire in
violating the uncertainty principle. We then discuss how different notions of a
quantum mixture that are indistinguishable in linear quantum mechanics lead to
dramatically differing conclusions in a nonlinear quantum mechanics involving
P-CTCs. Finally, we give explicit circuit constructions that can efficiently
factor integers, efficiently solve any decision problem in the intersection of
NP and coNP, and probabilistically solve any decision problem in NP. These
circuits accomplish these tasks with just one qubit traveling back in time, and
they exploit the ability of postselected closed timelike curves to create
grandfather paradoxes for invalid answers.Comment: 15 pages, 4 figures; Foundations of Physics (2011
C-Mpl Is Expressed on Osteoblasts and Osteoclasts and Is Important in Regulating Skeletal Homeostasis
C-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it may be expected that mice in which c-Mpl was globally knocked out (c-Mpl(-/-) mice) would have decreased bone mass because they have fewer MKs. Instead, c-Mpl(-/-) mice have a higher bone mass than WT controls. Using c-Mpl(-/-) mice we investigated the basis for this discrepancy and discovered that c-Mpl is expressed on both osteoblasts (OBs) and osteoclasts (OCs), an unexpected finding that prompted us to examine further how c-Mpl regulates bone. Static and dynamic bone histomorphometry parameters suggest that c-Mpl deficiency results in a net gain in bone volume with increases in OBs and OCs. In vitro, a higher percentage of c-Mpl(-/-) OBs were in active phases of the cell cycle, leading to an increased number of OBs. No difference in OB differentiation was observed in vitro as examined by real-time PCR and functional assays. In co-culture systems, which allow for the interaction between OBs and OC progenitors, c-Mpl(-/-) OBs enhanced osteoclastogenesis. Two of the major signaling pathways by which OBs regulate osteoclastogenesis, MCSF/OPG/RANKL and EphrinB2-EphB2/B4, were unaffected in c-Mpl(-/-) OBs. These data provide new findings for the role of MKs and c-Mpl expression in bone and may provide insight into the homeostatic regulation of bone mass as well as bone loss diseases such as osteoporosis
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
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