Sintesi di nuovi antagonisti selettivi del recettore A₂A dell’adenosina: derivati 3-Aril[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-onici

L’adenosina è un nucleoside endogeno implicato in molti processi fisiologici dell’organismo umano. Essa esplica la sua azione interagendo con specifici recettori di membrana accoppiati a proteina G classificati in A1-A2A-A2B-A3. Il recettore A2A, fulcro di questo lavoro di tesi, è soprattutto espresso a livello del SNC. Per interazione con questo sottotipo, l’adenosina svolge un ruolo importante nel rilascio di neurotrasmettitori come il glutammato, che, se liberato in modo eccessivo, porta a morte neuronale in patologie neurodegenerative come il Parkinson e l’Alzheimer. Lo scopo di questo lavoro di tesi è stato la progettazione e la sintesi di nuovi antagonisti selettivi per il recettore A2A dell’adenosina. Da un punto di vista strutturale i derivati presentano un nucleo triazinobenzimidazolico variamente sostituito in posizione 3 (gruppi 2-furilico e fenilico) e in posizione 10 (gruppi feniletilico, fenilpropilico, para-clorofenilico)

Are Coworkers in the Italian Peripheral Areas Performing Better? A Counterfactual Analysis

Coworking spaces are “serendipity accelerators” designed to host creative people and entrepreneurs. While recent literature has started exploring the indirect effects of coworking spaces on the local context, little is still known on how coworking spaces may directly affect the coworkers’ economic performance and wellbeing. Using a novel dataset based on a survey of 326 CWs working in the Italian coworking spaces in 2018, this paper explores the potential economic impact for coworkers, depending on whether a coworking space is localized in a peripheral or an urban area. Through a propensity-score matching approach, we found that being located in a peripheral area for coworkers may represent an opportunity to earn more than working in an urban center. The same holds for the organization coworkers belong to

Emerging Photovoltaic Technologies and Eco-Design—Criticisms and Potential Improvements

An efficient waste management for emerging photovoltaic (PV) technologies is not mature yet. The problematic aspects along with the possible failure’s identification have a pivotal role in modelling the future end-of-life management strategies. The identification of substances of concern (e.g. high cost, low availability, and high toxicity) and valuable materials is a key point to better define the research priorities to improve the eco-design of these technologies. The ultimate goal is to promote the disposal processes which enhance the repair, refurbishment, and recover opportunities and so the profitability of recycling. These studies can also prompt the investigation of innovative materials which are more cost-effective and/or coming from renewable resources or secondary raw materials. Forecasting the waste management technologies for the emerging photovoltaics is highly challenging. In this context, our purpose is to provide an overview of the critical elements and understand the appropriate corrective improvements towards more sustainable technologies

Natural semi-direct gauge mediation and D-branes at singularities

We consider semi-direct gauge mediation models of supersymmetry breaking where the messengers are composite fields and their supersymmetric mass is naturally generated through quartic superpotential couplings. We show that such composite messenger models can be easily embedded in quiver gauge theories arising from D-branes at Calabi-Yau singularities, and argue that semi-direct gauge mediation is in fact a very natural option for supersymmetry breaking in D-brane models. We provide several explicit examples and discuss their salient phenomenological properties.Comment: 20 pages, 5 figures. V2: Typos corrected and a note about putative unsuppressed gaugino mass adde