Randomly Evolving Idiotypic Networks: Structural Properties and Architecture

We consider a minimalistic dynamic model of the idiotypic network of B-lymphocytes. A network node represents a population of B-lymphocytes of the same specificity (idiotype), which is encoded by a bitstring. The links of the network connect nodes with complementary and nearly complementary bitstrings, allowing for a few mismatches. A node is occupied if a lymphocyte clone of the corresponding idiotype exists, otherwise it is empty. There is a continuous influx of new B-lymphocytes of random idiotype from the bone marrow. B-lymphocytes are stimulated by cross-linking their receptors with complementary structures. If there are too many complementary structures, steric hindrance prevents cross-linking. Stimulated cells proliferate and secrete antibodies of the same idiotype as their receptors, unstimulated lymphocytes die. Depending on few parameters, the autonomous system evolves randomly towards patterns of highly organized architecture, where the nodes can be classified into groups according to their statistical properties. We observe and describe analytically the building principles of these patterns, which allow to calculate number and size of the node groups and the number of links between them. The architecture of all patterns observed so far in simulations can be explained this way. A tool for real-time pattern identification is proposed.Comment: 19 pages, 15 figures, 4 table

Report on the Workshop on Sustainable Software Sustainability 2019 (WOSSS19)

This report is based on the discussions and presentations that took place at the Workshop on Sustainable Software Sustainability (www.software.ac.uk/wosss19) in April 2019 (WOSSS19). It captures the state of the art for a range of Software Sustainability themes that were brought up by the organisers and attendees of the workshop

Software for the frontiers of quantum chemistry:An overview of developments in the Q-Chem 5 package

This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange–correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with methods based on the algebraic diagrammatic construction and variational reduced density-matrix methods. Methods highlighted in Q-Chem 5 include a suite of tools for modeling core-level spectroscopy, methods for describing metastable resonances, methods for computing vibronic spectra, the nuclear–electronic orbital method, and several different energy decomposition analysis techniques. High-performance capabilities including multithreaded parallelism and support for calculations on graphics processing units are described. Q-Chem boasts a community of well over 100 active academic developers, and the continuing evolution of the software is supported by an “open teamware” model and an increasingly modular design

Angle-of-arrival anemometry by means of a large-aperture Schmidt-Cassegrain telescope equipped with a CCD camera

The frequency spectrum of angle-of-arrival (AOA) fluctuations of optical waves propagating through atmospheric turbulence carries information of wind speed transverse to the propagation path. We present the retrievals of the transverse wind speed, v b , from the AOA spectra measured with a Schmidt-Cassegrain telescope equipped with a CCD camera by estimating the "knee frequency," the intersection of two power laws of the AOA spectrum. The rms difference between 30 s estimates of v b retrieved from the measured AOA spectra and 30 s averages of the transverse horizontal wind speed measured with an ultrasonic anemometer was 11 cm s −1 for a 1 h period, during which the transverse horizontal wind speed varied between 0 and 80 cm s −1 . Potential and limitations of angle-of-arrival anemometry are discusse

Hypobaric hypoxia-reoxygenation diminishes band 3 protein functions in human erythrocytes

We have previously shown that subjects exposed to acute hypobaric hypoxia display an erythrocyte membrane protein band 3 with an increased susceptibility to proteolytic degradation. We suggested it was due to an oxidative damage of band 3. We now report that exposure to hypobaric hypoxia followed by reoxygenation affects protein band 3 functions such as anion transport and binding of glyceraldehyde-3P-dehydrogenase. Transport capacity was assessed with the fluorescent probe 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino] ethanesulfonate (NBD-taurine). Binding capacity was evaluated from the activity of the membrane-associated enzyme. Healthy young men were exposed for 20 min to hypobaric hypoxia, simulating an altitude of 4,500 m above sea level and after recompression band 3 function was assessed. An inhibition of band 3 anion transport function and a decrease in the binding of glyceraldehyde-3P-dehydrogenase to band 3 were observed. Evidence is given supporting the hypothesis that fu

METCRAX 2006 - Meteorological experiments in Arizona\u27s Meteor Crater

The Meteor Crater Experiment (METCRAX 2006) was conducted in October 2006 at Arizona\u27s Meteor Crater to investigate stable boundary layer evolution in a topographically uncomplicated basin surrounded by the nearly homogeneous plain of the Colorado Plateau. The two goals of the experiment were 1) to investigate the microscale and mesoscale structure and evolution of the stable boundary layer in the crater and its surroundings and 2) to determine whether atmospheric seiches or standing waves are produced inside the crater. This article provides an overview of the scientific goals of the experiment; summarizes the research measurements, the crater topography, and the synoptic meteorology of the study period; and presents initial analysis results. Analyses show that nighttime temperature inversions form frequently in the crater and that they are often perturbed by internal wave motions. Nighttime cooling produces a shallow (15–30 m deep) surface-based inversion that is surmounted by a horizontally homogeneous near-isothermal layer that extends all the way to the rim, where a second inversion extends above rim level. Seiches are sometimes present on the crater floor. The diurnal propagation of shadows from the crater rim produces important spatial differences in the surface radiation budget and thus the timing of the slope flow transition, and the crater atmosphere is often perturbed during nighttime by a southwesterly mesoscale drainage flow

Software for the frontiers of quantum chemistry: An overview of developments in the Q-Chem 5 package.

This article summarizes technical advances contained in the fifth major release of the Q-Chem quantum chemistry program package, covering developments since 2015. A comprehensive library of exchange-correlation functionals, along with a suite of correlated many-body methods, continues to be a hallmark of the Q-Chem software. The many-body methods include novel variants of both coupled-cluster and configuration-interaction approaches along with methods based on the algebraic diagrammatic construction and variational reduced density-matrix methods. Methods highlighted in Q-Chem 5 include a suite of tools for modeling core-level spectroscopy, methods for describing metastable resonances, methods for computing vibronic spectra, the nuclear-electronic orbital method, and several different energy decomposition analysis techniques. High-performance capabilities including multithreaded parallelism and support for calculations on graphics processing units are described. Q-Chem boasts a community of well over 100 active academic developers, and the continuing evolution of the software is supported by an "open teamware" model and an increasingly modular design