Características clínico-epidemiológicas do câncer infantojuvenil no estado de Alagoas, Brasil

Objetivo: Avaliar os aspectos clínico-epidemiológicos do câncer infantojuvenil em Alagoas. Métodos: Trata-se de um estudo transversal, de caráter retrospectivo e quantitativo. As informações referentes aos diagnósticos de neoplasias infantojuvenis no Estado de Alagoas foram coletadas a partir de consulta aos prontuários dos centros de referência estaduais para tratamento de câncer na população de 0 a 19 anos. Resultados: Quanto ao perfil dos acometidos, a incidência maior foi em indivíduos do sexo masculino entre 5-9 anos, pardos, sem escolaridade, procedentes da 1ª região de saúde. As neoplasias mais frequentes foram: tumores hematológicos (leucemias e linfomas), tumores do sistema nervoso central, renais, ósseos, retinoblastoma e partes moles. A terapêutica mais empregada no tratamento dos casos foi a quimioterapia. Houve aumento na média de diagnósticos de casos novos de câncer infantojuvenil na população do estado de Alagoas. A letalidade do câncer infantojuvenil no período foi de 14,6%. Conclusão: O câncer infantojuvenil em Alagoas, em concordância com o cenário nacional e internacional, continua sendo uma doença relativamente rara e de baixa incidência. O aumento dos casos verificado para o Estado pode estar associado a diversos fatores, entre estes, a maior capacitação profissional para triagem de sinais e sintomas clínicos, com consequente encaminhamento as unidades especializadas para investigação e diagnóstico precoce.Objective: The purpose of this study was to evaluate the clinical and epidemiological findings of childhood cancer in Alagoas. Methods: This is a cross-sectional, retrospective and quantitative study. All information related to the diagnosis of childhood neoplasms was collected from the records of Alagoas Oncology Centers. Results: The highest incidence was of males aged 5-9 years, brown, with no schooling, coming from the 1st health region. The most frequent neoplasms were: hematological tumors (leukemias and lymphomas), tumors of the central nervous system, renal, bone, retinoblastoma and soft tissues. The most used therapy in the treatment of the cases was chemotherapy. There was an increase in the average of diagnoses of new cases of childhood and adolescent cancer in the state of Alagoas. The lethality of childhood cancer in the period was 14.6%. Conclusion: Childhood cancer in Alagoas remains to be a relatively rare and low incidence disease. The increase of the cases verified for the State may be associated to several factors, among them, the greater professional qualification for screening of clinical signs and symptoms, with consequent referral to specialized units for early diagnostic investigation

The Brazilian Registry of Adult Patient Undergoing Cardiovascular Surgery, the BYPASS Project: Results of the First 1,722 Patients

Objective: To report the early results of the BYPASS project - the Brazilian registrY of adult Patient undergoing cArdiovaScular Surgery - a national, observational, prospective, and longitudinal follow-up registry, aiming to chart a profile of patients undergoing cardiovascular surgery in Brazil, assessing the data harvested from the initial 1,722 patients. Methods: Data collection involved institutions throughout the whole country, comprising 17 centers in 4 regions: Southeast (8), Northeast (5), South (3), and Center-West (1). The study population consists of patients over 18 years of age, and the types of operations recorded were: coronary artery bypass graft (CABG), mitral valve, aortic valve (either conventional or transcatheter), surgical correction of atrial fibrillation, cardiac transplantation, mechanical circulatory support and congenital heart diseases in adults. Results: 83.1% of patients came from the public health system (SUS), 9.6% from the supplemental (private insurance) healthcare systemsand 7.3% from private (out-of-pocket) clinic. Male patients comprised 66%, 30% were diabetics, 46% had dyslipidemia, 28% previously sustained a myocardial infarction, and 9.4% underwent prior cardiovascular surgery. Patients underwent coronary artery bypass surgery were 54.1% and 31.5% to valve surgery, either isolated or combined. The overall postoperative mortality up to the 7th postoperative day was 4%for CABG was 2.6%, and for valve operations, 4.4%. Conclusion: This first report outlines the consecution of the Brazilian surgical cardiac database, intended to serve primarily as a tool for providing information for clinical improvement and patient safety and constitute a basis for production of research protocols.Univ Fed Sao Paulo UNIFESP EPM, Hosp Sao Paulo, Sao Paulo, SP, BrazilHosp Caridade Sao Vicente Paulo, Jundiai, SP, BrazilInst Med Integral Prof Fernando Figueira IMIP, Recife, PE, BrazilHosp Base FUNFARME & FAMERP, Sao Jose Do Rio Preto, SP, BrazilIMC, Sao Jose Do Rio Preto, SP, BrazilIrmandade Santa Casa Sao Paulo INCT HPV, Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, SP, BrazilFundacao Univ Cardiol, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, BrazilInst Coracao Natal, Natal, RN, BrazilInst Cardiol Dist Fed, Brasilia, DF, BrazilUniv Fed Maranhao HU UFMA, Univ Hosp, Sao Luis, MA, BrazilHosp Evangelico, Cachoeiro De Itapemirim, ES, BrazilHosp Coracao Sergipe, Aracaju, SE, BrazilHosp Nossa Senhora Salete, Inst Cirurgia Cardiovasc ICCV, Cascavel, PR, BrazilHosp Wilson Rosado, Mossoro, RN, BrazilHosp Bosque Saude, Sao Paulo, SP, BrazilHosp Univ Santa Maria, Santa Maria, RS, BrazilHosp Coracao HCor, Sao Paulo, SP, BrazilHosp Coracao IP HCor, Ins Pesquisa, Sao Paulo, SP, BrazilInst Coracao InCor, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP EPM, Hosp Sao Paulo, Sao Paulo, SP, BrazilWeb of Scienc

Search for New Physics in the Multijet and Missing Transverse Momentum Final State in Proton-Proton Collisions at √s=7 TeV

A search for physics beyond the standard model is performed in events with at least three jets and large missing transverse momentum produced in proton-proton collisions at sqrt(s) = 7 TeV. No significant excess of events above the expected backgrounds is observed in 4.98 inverse femtobarns of data collected with the CMS detector at the Large Hadron Collider. The results are presented in the context of the constrained minimal supersymmetric extension of the standard model and more generically for simplified models. For the simplified models of gluino-gluino and squark-squark production, gluino masses below 1.0 TeV and squark masses below 0.76 TeV are excluded in case the lightest supersymmetric particle mass is below 200 GeV. These results significantly extend previous searches

Microcefalia no Brasil: prevalência e caracterização dos casos a partir do Sistema de Informações sobre Nascidos Vivos (Sinasc), 2000-2015

Resumo OBJETIVO: descrever os coeficientes de prevalência e caracterizar os casos de microcefalia ao nascer no Brasil, no período 2000-2015. MÉTODOS: estudo descritivo com dados do Sistema de Informações sobre Nascidos Vivos (Sinasc). Foram calculados coeficientes segundo regiões e características das mães e nascidos vivos (NV). RESULTADOS: a média anual de casos de microcefalia foi 164 no período 2000-2014, enquanto em 2015 foram registrados 1.608 casos (54,6 casos por 100 mil NV). Coeficientes mais elevados foram observados entre prematuros (81,7; IC95%72,3; 92,2), nascidos de mães pretas (70,9; IC95%58,5; 85,9) ou pardas (71,5; IC95%67,4; 75,8), com idades ≤19 (70,3; IC95%63,5; 77,8) ou ≥40 anos (62,1; IC95%46,6; 82,6), ≤3 anos de estudo (73,4; IC95%58,2; 92,4) e residentes na região Nordeste (138,7; IC95%130,9; 147,0). CONCLUSÃO: o elevado número de casos de microcefalia registrado em 2015 reforça a importância do Sinasc e do aprimoramento do sistema de vigilância das anomalias congênitas

Clarity perceived about vaccine information between hesitant and non-hesitant (N = 172,314).

Clarity perceived about vaccine information between hesitant and non-hesitant (N = 172,314).</p

Brazilians perceived trustworthiness of sources of information about the vaccine for the prevention of COVID-19 according to vaccine hesitancy (n = 173,178, with 18,250 hesitant and 154,928 non-hesitant).

Some participants did not report trustworthiness in some information sources.</p

Strategies indicated to increase the percentage of vaccine adherence to prevent COVID-19 according to the intention to vaccinate.

Strategies indicated to increase the percentage of vaccine adherence to prevent COVID-19 according to the intention to vaccinate.</p

Multivariate logistic regression to assess factors associated with trust in the information source.

Multivariate logistic regression to assess factors associated with trust in the information source.</p