Marijana Kokanovic Markovic, The Social Role of the Salon Music in the Life and the Value System of the Serbian Citizens in the 19th Century, Belgrad: Institute of Musicology SASA 2014 [Zusammenfassung]

Salon music, which marked the private sphere of music life during the 19th century, until recently represented an aesthetically uninteresting phenomenon. Musicological researches were, primarily, focused on art music, while the research of salon music was at the margin of scientific interest

THE VARIABILITY OF MULTI-DRUG RESISTANCE ABCB1 GENE IN THE ROMA POPULATION FROM CROATIA

When overexpressed, a large transmembrane P-glycoprotein, the product of the ABCB1 gene, is a notable impediment to brain-targeted therapies (like antiepileptics) and chemotherapies. Some of the genetic biomarkers with evidence of multi-drug resistance in ABCB1 ― rs1045642, rs1128503, and rs3213619 ― were analyzed in 440 subjects, members of three socio-culturally different Roma (Gypsy) groups of Croatia. Minor allele frequencies (MAFs) of rs1045642 and rs1128503 were the highest in the Balkan Roma (63.6% and 69.4%, respectively) when compared to the Baranja (52.3% and 62.5%) and the Međimurje Roma (48.8% and 54.5%) (p=0.0005 and p=0.0011, respectively). rs3213619 was monomorphic in the Međimurje group, while its MAFs in other two Roma groups were very low (<1.9%). The distribution of five detected haplotypes (four in the Međimurje group) significantly differed between the Roma subpopulations (p<0.0001), just like the frequencies of diplotypes (p=0.0008). At a global scale, the positive relationship between genetic and geographic distances between the 21 investigated populations indicates isolation by spatial distance. However, this is not true for the relationship between Roma and other populations due to their population history. The analyzed ABCB1 loci indicate genetic distinctiveness of the Roma population

Antioksidativna i inhibitorska aktivnost Alizarin-2-glikozida

In this paper was investigated the antioxidative activity of alizarin-2-glycoside. All results were obtained using the DFT method. For calculations, the M06-2X method was used in combination with the 6-311++G(d,p) base set. Water was used as a solvent. The values of enthalpy were used as thermodynamic parameters on the basis of which the antioxidative capacity of alizarin-2-glycoside was evaluated. The Molecular Docking method was used for assessing the ability of alizarin-2-glycoside to inhibit the negative effect of P-glycoprotein.U ovom radu je ispitana antioksidativna aktivnost alizarin-2-glikozida. Svi rezultati dobijeni su primenom DFT metode. Za izračunavanja je korišćena M06-2X metoda u kombinaciji sa 6-311++G(d,p) bazisnim skupom. Kao rastvarač korišćena je voda. Vrednosti entalpija korišćene su kao termodinamički parametri na osnovu kojih je procenjen antioksidativni kapacitet alizarin-2-glikozida. Molecular Docking metodom procenjena je sposobnost alizarin-2-glikozida da inhibira negativan uticaj P-glikoproteina

Predicting the survival probability of functional neuroendocrine tumors treated with peptide receptor radionuclide therapy: Serbian experience

IntroductionPeptide receptor radionuclide therapy (PRRT) is a treatment option for well-differentiated, somatostatin receptor positive, unresectable or/and metastatic neuroendocrine tumors (NETs). Although high disease control rates seen with PRRT a significant number NET patients have a short progression-free interval, and currently, there is a deficiency of effective biomarkers to pre-identify these patients. This study is aimed at determining the prognostic significance of biomarkers on survival of patients with NETs in initial PRRT treatment.MethodologyWe retrospectively analyzed 51 patients with NETs treated with PRRT at the Department for nuclear medicine, University Clinical Center Kragujevac, Serbia, with a five-year follow-up. Eligible patients with confirmed inoperable NETs, were retrospectively evaluated hematological, blood-based inflammatory markers, biochemical markers and clinical characteristics on disease progression. In accordance with the progression og the disease, the patients were divided into two groups: progression group (n=18) and a non-progression group (n=33). Clinical data were compared between the two groups.ResultsA total of 51 patients (Md=60, age 25-75 years) were treated with PRRT, of whom 29 (56.86%) demonstrated stable disease, 4 (7.84%) demonstrated a partial response, and 14 (27.46%) demonstrated progressive disease and death was recorded in 4 (7.84%) patients. The mean PFS was a 36.22 months (95% CI 30.14-42.29) and the mean OS was 44.68 months (95% CI 37.40-51.97). Univariate logistic regression analysis displayed that age (p&lt;0.05), functional tumors (p&lt;0.05), absolute neutrophil count (p&lt;0.05), neutrophil-lymphocyte ratio-NLR (p&lt;0.05), C-reactive protein-CRP (p&lt;0.05), CRP/Albumin (p&lt;0.05), alanine aminotransferase-ALT (p&lt;0.05), were risk factors for disease progression. Multivariate logistic regression analysis exhibited that functional tumors (p&lt;0.001), age (p&lt;0.05), CRP (p&lt;0.05), and ALT (p&lt;0.05), were independent risk factors for the disease progression in patients with NETs. Tumor functionality was the most powerful prognostic factor. The median PFS (11.86 ± 1.41 vs. 43.38 ± 3.16 months; p=0.001) and OS (21.81 ± 2.70 vs 53.86 ± 3.70, p=0.001) were significantly shorter in patients with functional than non-functional NETs respectively.ConclusionThe study’s results suggest that tumor functionality, and certain biomarkers may serve as prognostic survival indicators for patients with NETs undergoing PRRT. The findings can potentially help to identify patients who are at higher risk of disease progression and tailor treatment strategies accordingly

Marijana Kokanovic Markovic, The Social Role of the Salon Music in the Life and the Value System of the Serbian Citizens in the 19th Century, Belgrad: Institute of Musicology SASA 2014 [Zusammenfassung]

Salon music, which marked the private sphere of music life during the 19th century, until recently represented an aesthetically uninteresting phenomenon. Musicological researches were, primarily, focused on art music, while the research of salon music was at the margin of scientific interest

FAMILY PLANNING IN WOMEN OF DIFFERENT AGE

Objectives of family planning that are usually mentioned are unwanted pregnancy prevention, extensive population growth reduction, health improvement of women, children and population as a whole.The study objective was to make an assessment about the state of knowledge and characteristics of using methods for family planning in women of diferente age in the Municipality of Nis. The study included 1584 women aged 15-49. The data were collected by conducting the poll.Contraception was defined as the method of family planning mostly by interviewees older than 35 years of age, while this was the least case with interviewees younger than the age of 20. The interviewees younger than the age of 20 usually get information from several sources, the older, from newspapers and media. The interviewees up to 35 years of age think that condom is the most efficient method of contraception. The interviewees aged 36-49 think that the most efficient method of contraception is the intra-uterus spiral. Most of the interviewees (88.8%) estimate their knowledge about contraception as satisfactory. 81.9% of interviewees, having sexual relations protect themselves from unwanted pregnancy permanently or occasionally. Modern means of contraception are used by 72% of interviewees younger than the age of 20. Interviewees of all age categories mostly make the decision on their own about the contraception use. 35% of interviewees estimate their method of contraception as completely safe. The greatest number of interviewees with intentionally interrupted pregnancies came from the age group 36-49 (53.8%).Women’s knowledge about family planning and the use of methods of contraception is unsatisfactory

Epidemiological Trends in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair over the Last Decade: Functional vs. Structural Mitral Regurgitation

Objective: We aimed to investigate the demographic, clinical and hemodynamic characteristics of patients who underwent percutaneous mitral valve (MV) repair over the last decade, as well as to determine the potential changes in trends of these parameters among patients with structural and functional MR (SMR and FMR). Methodology: We analyzed all patients who underwent interventional MV repair in our institution between January 2010 and March 2021. Our study included both SMR and FMR patients. All data were obtained from a local registry. Results: Nine hundred and seventeen patients (357 SMR patients and 563 FMR patients) were involved in this study. We did not find significant differences in demographical, clinical and hemodynamic characteristics among SMR and FMR patients. Left ventricular remodeling and systolic dysfunction were more pronounced in FMR patients. Systemic vascular resistance was the only hemodynamic parameter that differed between SMR and FMR patients; it was higher in SMR group. An evaluation of the trend between the first and last five years of our experience revealed that the number of patients treated with this technique is constantly increasing, but that this is more pronounced in SMR patients. It was also found that the operative risk of SMR and FMR patients was significantly higher in the first five years. Additionally, our results showed change in medical therapy in MR patients over the last decade in terms of increased use of angiotensin II receptor blockers and the introduction of angiotensin receptor II blocker-neprilysin inhibitor. Conclusion: SMR and FMR patients who underwent interventional MV repair have similar clinical and hemodynamic characteristics. The percentage of SMR patients increased more significantly than FMR patients over the last five years

Sea Buckthorn Oil—A Valuable Source for Cosmeceuticals

Sea buckthorn (Hippophae rhamnoides L., Elaeagnaceae.) is a thorny shrub that has small, yellow to dark orange, soft, juicy berries. Due to hydrophilic and lipophilic ingredients, berries have been used as food and medicine. Sea buckthorn (SB) oil derived from berries is a source of valuable ingredients for cosmeceuticals. The unique combination of SB oil ingredients, in qualitative and quantitative aspects, provides multiple benefits of SB oil for internal and external use. Externally, SB oil can be applied in both healthy and damaged skin (burns or skin damage of different etiology), as it has good wound healing properties. Due to the well-balanced content of fatty acids, carotenoids, and vitamins, SB oil may be incorporated in cosmeceuticals for dry, flaky, burned, irritated, or rapidly ageing skin. There have been more than 100 ingredients identified in SB oil, some of which are rare in the plant kingdom (e.g., the ratio of palmitoleic to γ-linolenic acid). This review discusses facts related to the origin and properties of SB oil that make it suitable for cosmeceutical formulation

Le Grand écho du Nord de la France

26 juin 19051905/06/26 (A87,N177).Appartient à l’ensemble documentaire : NordPdeC