9 research outputs found
Influence de la nature des graisses alimentaires sur la captation et l'absorption intestinale du cholestérol
Quality of life for older patients with cancer: a review of the evidence supporting melatonin use
International audienc
Fourteen novel OPA1 mutations in autosomal dominant optic atrophy including two de novo mutations in sporadic optic atrophy
International audienc
Believing in Victorian Times
Ce numĂ©ro des Cahiers victoriens et Ă©douardiens traite de la croyance en Angleterre dans la seconde moitiĂ© du XIXe siĂšcle. Croyance des individus, croyances mises en jeu par la littĂ©rature, croyances soutenues par des systĂšmes philosophiques, ou conflictuelles au sein dâun groupe, ces formes de croyance sont lâĆuvre dans le façonnement du paysage littĂ©raire et intellectuel victorien. Ce paysage a longtemps Ă©tĂ© perçu Ă travers le prisme du conflit entre science et religion ou celui de la perte de la foi Ă partir de 1850. Câest lĂ rĂ©duire le foisonnement des questions et des angles dâapproche, ramener la diversitĂ© des positions Ă une sĂ©rie dâantagonismes. Les articles qui suivent sâintĂ©ressent aux formes, aux trajets, aux enjeux et aux catĂ©gories de la croyance Ă lâĂ©poque victorienne et proposent des pistes dâexploration fructueuses dans le champ littĂ©raire, social et intellectuel. The following issue of the Cahiers victoriens et Ă©douardiens discusses various forms of belief in the Victorian times. It addresses the question of individual, literary, philosophical, or community beliefs, including their conflict, that shaped the intellectual and literary Victorian landscape. For a long time belief in the Victorian times has been characterised by the conflict between science and religion, or by the question of the mid-Victorian âloss of faithâ. Such an approach may lead to reducing the diversity of individual or group positions to mere series of conflicts. Included here are essays on the forms, trajectories, stakes and categories of belief. All suggest fruitful approaches within the literary, social and intellectual field
Relative Frequencies of Inherited Retinal Dystrophies and Optic Neuropathies in Southern France: Assessment of 21-year Data Management
International audiencePURPOSE:Inherited retinal dystrophies (IRDs) and inherited optic neuropathies (IONs) are rare diseases defined by specific clinical and molecular features. The relative prevalence of these conditions was determined in Southern France.METHODS:Patients recruited from a specialized outpatient clinic over a 21-year period underwent extensive clinical investigations and 107 genes were screened by polymerase chain reaction/sequencing.RESULTS:There were 1957 IRD cases (1481 families) distributed in 70% of pigmentary retinopathy cases (56% non-syndromic, 14% syndromic), 20% maculopathies and 7% stationary conditions. Patients with retinitis pigmentosa were the most frequent (47%) followed by Usher syndrome (10.8%). Among non-syndromic pigmentary retinopathy patients, 84% had rod-cone dystrophy, 8% cone-rod dystrophy and 5% Leber congenital amaurosis. Macular dystrophies were encountered in 398 cases (30% had Stargardt disease and 11% had Best disease). There were 184 ION cases (127 families) distributed in 51% with dominant optic neuropathies, 33% with recessive/sporadic forms and 16% with Leber hereditary optic neuropathy. Positive molecular results were obtained in 417/609 families with IRDs (68.5%) and in 27/58 with IONs (46.5%). The sequencing of 5 genes (ABCA4, USH2A, MYO7A, RPGR and PRPH2) provided a positive molecular result in 48% of 417 families with IRDs. Except for autosomal retinitis pigmentosa, in which less than half the families had positive molecular results, about 75% of families with other forms of retinal conditions had a positive molecular diagnosis.CONCLUSIONS:Although gene discovery considerably improved molecular diagnosis in many subgroups of IRDs and IONs, retinitis pigmentosa, accounting for almost half of IRDs, remains only partly molecularly defined
Monensin action on the Golgi complex in perfused rat liver: Evidence against bile salt vesicular transport
High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohnâs Disease
International audienceBackground & AimsLittle is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohnâs disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohnâs perianal disease followed up in the Cancers Et Surrisque AssociĂ© aux Maladies Inflammatoires Intestinales En France (CESAME) cohort.MethodsWe collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohnâs disease. Subjects were followed up for a median time of 35 months (interquartile range, 29â40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex.ResultsAmong the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohnâs lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistulaârelated adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistulaârelated adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohnâs disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% CI, 1.18-551.51; P = .03).ConclusionsIn an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohnâs disease have a high risk of anal cancer, including perianal fistulaârelated cancer, and a high risk of rectal cancer