Association between dietary saccharide intake and self-reported memory performance in middle-aged adults

The aims of the present study were to assess dietary intake of saccharides in middle-aged adults, and to determine whether intakes of these sugar nutrients were related to self-reported memory performance. A population-based sample of 1183 men and women (aged 40-60 years) completed questionnaires assessing everyday memory function. Dietary intake status of saccharides was estimated using a self-completed, quantified FFQ. After controlling for demographic and health measures (for example, time spent exercising, smoking and alcohol consumption), saccharide intake was related to better self-reported memory functioning. Thus, longer-term intakes of saccharides through the usual diet may be positively related to perceived memory performance in mid-life

Saccharide Effects on Cognition and Well-Being in Middle-Aged Adults: A Randomized Controlled Trial

Author version made available in accordance with the publisher's policy.The current study used a randomised, double-blind, placebo-controlled design to investigate the effects of saccharide supplementation on cognition and well-being in middle-aged adults. Participants (N=109; 45 - 60 years) took a teaspoon of a combination of saccharides or a placebo twice daily for 12 weeks (3.6 g per day). Before and after this supplementation period, participants completed alternate forms of standardised tests of cognition and self-report measures of well-being. Significant beneficial effects of saccharide supplementation were found for memory performance and indicators of well-being. The potential for these nutrients to optimise cognitive function and well-being in older adults warrants on-going investigation

Perceived Changes in Well-Being Following Polysaccharide Intake in Middle-Aged Adults

Author version made available in accordance with the publisher's policy.Objectives: There is increased scientific interest in the effects of nutrition on cognition and well-being. Plant sourced polysaccharides play multiple roles in the biological processes required for health and well-being. This study explored the subjective experiential reports of well-being following intake of a plant derived polysaccharide supplement. Design: The study used a 12 week double-blind, placebo controlled polysaccharide supplementation design. Method: 109 middle-aged adults (45-60 years) took a standardised teaspoon of a combination of plant polysaccharides or a placebo twice daily for 12 weeks (3.6 g per day), and completed three, open-ended interviews at weeks 4, 8 and 12. Results: Participants who took the polysaccharide supplement reported significantly more perceived beneficial changes in both physical and psychological well-being, specifically at week 12, compared to those who received the placebo. Conclusion: This study provides a starting point for understanding the perceived beneficial impact of polysaccharide interventions on aspects of well-being. Importantly, as a healthrelated application of polysaccharide science, this research supports the relationship that is emerging between the properties and function of polysaccharides. It is essential that future research assesses the effects of polysaccharide intake on a range of physical and psychological well-being outcomes to further the understanding of structure-function relationships with the aim of enhancing the functional health and well-being of individuals

Spiritual Care in Palliative Care

Palliative care has always included spiritual care, but the provision and inclusion of spiritual care within and across palliative care services internationally is sub-optimal. In this summary overview, we address understandings and meanings of spirituality and related terms, both generally and in the context of healthcare, and outline the importance of spiritual well-being and spiritual care at the end of life. We summarise what spiritual care involves, its benefits for palliative care patients and their families, and consider how its provision might be helped or hindered. There is currently a limited evidence base for the efficacy of interventions including spiritual and/or religious care, and large-scale studies in particular are lacking. However, those mostly small-scale and/or qualitative studies which have been conducted to date show that addressing the spiritual needs of patients in palliative care is associated with many positive outcomes for both patients and their relatives. More research in this area is necessary to develop and enhance the evidence base, and optimal provision of spiritual care requires that providers explicitly recognise the need for such care, including through providing training and support for staff

Teachers\u27 Perceptions of African American Middle School Girls\u27 Interest in Mathematics and Science

Research into African American female underrepresentation in science, technology, engineering, and mathematics (STEM) fields has become an area of interest due to the fact that a majority of African American middle school females do not possess the high levels of mathematics and science knowledge because of social and cultural barriers both inside and outside school that challenge their academic success. The purpose of this qualitative interpretative phenomenological study was to explore teachers\u27 shared, lived experiences of teaching mathematics and science to African American middle school girls. Delgado and Stefancic\u27s critical race theory, Pratt-Clarke\u27s critical race feminism, and Baker-Miller\u27s relational-cultural theory were used to guide this study. Research questions focused on the perceptions and experiences of teachers\u27 lived experiences teaching mathematics and science to African American middle school females. Criterion, purposive, and maximum variation sampling techniques were used to recruit 10 teachers who have 3 or more years\u27 experience teaching African American middle school girls. Semistructured face-to-face interviews were the primary data collection source. First cycle and second cycle coding methods were used to support the analysis of this study. Findings suggest that there is a connection between a positive student-teacher relationship and academic success. The results of this study contribute to positive social change by providing empirical evidence policymakers and teachers can use to improve the mathematics and science instruction and practices that are needed to meet the needs of African American middle school females and reduce the underrepresentation and underachievement of African American females in mathematics and science

The response of young adult smokers and nonsmokers in the United Kingdom to dissuasive cigarettes: An online survey

Introduction  The cigarette stick is an important communications tool as well as the object of consumption. We explored young adults’ responses to cigarettes designed to be dissuasive.  Methods  Data come from a cross-sectional online survey, conducted in September 2015, with 16-24 year old smokers and non-smokers (N=997) in the United Kingdom. Participants were shown images of a standard cigarette (white cigarette paper with imitation cork filter), a standard cigarette displaying the warning ‘Smoking kills’ on the cigarette paper, and an unattractively coloured cigarette (green cigarette paper and filter). They were asked to rate each of the three cigarettes, shown individually, on eight perception items, and to rate the three cigarettes, shown together, on how likely they would be to try them. Ordering of the cigarettes and questions, with the exception of the question on trial, was randomised.  Results  The eight perceptions items were combined to form a composite measure of cigarette perceptions. For smokers and non-smokers, the two dissuasive cigarettes (cigarette with warning, green cigarette) were rated significantly less favourably than the standard cigarette, and less likely to encourage trial. For cigarette perceptions no significant interaction was detected between cigarette style and smoking status or susceptibility to smoke among never smokers. A significant interaction was found for likelihood of trying the cigarettes, with dissuasive cigarettes having a greater impact with smokers than non-smokers.  Conclusions  This study suggests that dissuasive cigarettes may help to reduce the desirability of cigarettes.  Implications The cigarette stick is the object of tobacco consumption, which is seen every time a cigarette is smoked. It is also an increasingly important promotional tool for tobacco companies. In this study, young adults rated two dissuasive cigarettes (a green coloured cigarette and a cigarette displaying a health warning) more negatively than a standard cigarette, and considered them less likely to encourage product trial. Our findings suggest that it may be possible to reduce the desirability of cigarette sticks by altering their design, e.g. with the addition of a warning or use of an unattractive colour

Definitive endoderm derived from human embryonic stem cells highly express the integrin receptors αV and β5

Human embryonic stem cells (hESCs) can be directed to differentiate into a number of endoderm cell types, however mature functional cells have yet to be produced in vitro. This suggests that there may be important factors that have yet to be described, which may be essential for the proper derivation of these cells. One such factor is the integrin mediated interactions between a cell and the extracellular matrix (ECM). On this basis, the present study investigated the role of the ECM in the directed differentiation of hESCs to definitive endoderm via analysis of integrin gene expression. The results showed that definitive endoderm can be efficiently and effectively derived from hESCs in a feeder free, single defined ECM of laminin. Analysis of integrin expression also showed that definitive endoderm highly express the integrins αV and β5, which have the ability to bind to vitronectin, whilst expression of the pluripotency related laminin binding integrins α3, α6 and β4 were downregulated. This suggested a potential role of vitronectin binding integrins in the development of definitive endoderm. © 2010 Landes Bioscience

Voluntary Wheel Running in Old C57BL/6 Mice Reduces Age-Related Inflammation in the Colon but Not in the Brain

Inflammation is considered a possible cause of cognitive decline during aging. This study investigates the influence of physical activity and social isolation in old mice on their cognitive functions and inflammation. The Barnes maze task was performed to assess spatial learning and memory in 3, 9, 15, 24, and 28 months old male C57BL/6 mice as well as following voluntary wheel running (VWR) and social isolation (SI) in 20 months old mice. Inflammatory gene expression was analyzed in hippocampal and colonic samples by qPCR. Cognitive decline occurs in mice between 15 and 24 months of age. VWR improved cognitive functions while SI had negative effects. Expression of inflammatory markers changed during aging in the hippocampus ( Il1a / Il6 / S100b / Iba1 / Adgre1 / Cd68 / Itgam ) and colon ( Tnf / Il6 / Il1ra / P2rx7 ). VWR attenuates inflammaging specifically in the colon ( Ifng / Il10 / Ccl2 / S100b / Iba1 ), while SI regulates intestinal Il1b and Gfap . Inflammatory markers in the hippocampus were not altered following VWR and SI. The main finding of our study is that both the hippocampus and colon exhibit an increase in inflammatory markers during aging, and that voluntary wheel running in old age exclusively attenuates intestinal inflammation. Based on the existence of the gut-brain axis, our results extend therapeutic approaches preserving cognitive functions in the elderly to the colon

Simple Models of Plant Learning and Memory

Plants are capable of intelligent responses to complex environmental signals. Learning and memory play fundamental roles in such responses. Two simple models of plant memory are proposed based on the calcium-signalling system. The memory states correspond to steady state distributions of calcium ions.Comment: 10 pages,Proceedings of international conference on unconventional application of statistical physics(to be published in Physica Scripta