Stay with Me: Uncertain Indices and Attentional Presence in Chat Interfaces

In this article, Herrie and Sørensen examine the mediation of typing indicators (“…”) in online messaging. Their point of departure is a scene from the contemporary novel Exciting Times by Naoise Dolan (2020), in which the ‘dots’ play a prominent role. Their analysis shows how typing indicators, as interface design, mediate the complex communication situation in which they take part: from being mere signals, they have slipped into our emotional lives. From a semiotic perspective (Charles S. Peirce), the authors define typing indicators as uncertain indices which through unknowability and suspense establish an attentional presence. In continuation hereof, the authors argue that the acts of writing and waiting in contemporary attentional ecologies (Yves Citton) through the mediation of typing indicators as indicators of attentional presence, could be considered a mode of caring (Bernard Stiegler)

Invited review: Lying time and the welfare of dairy cows

Adequate time lying down is often considered an important aspect of dairy cow welfare. We examine what is known about cows’ motivation to lie down and the consequences for health and other indicators of biological function when this behavior is thwarted. We review the environmental and animal-based factors that affect lying time in the context of animal welfare. Cows can be highly motivated to lie down. They show rebound lying behavior after periods of forced standing and will sacrifice other activities, such as feeding, to lie down for an adequate amount of time. They will work, by pushing levers or weighted gates, to lie down and show possible indicators of frustration when lying behavior is thwarted. Some evidence suggests that risk of lameness is increased in environments that provide unfavorable conditions for cows to lie down and cows are forced to stand. Lameness itself can result in longer lying times, whereas mastitis reduces it. Cow-based factors such as reproductive status, age, and milk production influence lying time, but the welfare implications of these differences are unknown. Lower lying times are reported in pasture-based systems, dry lots, and bedded packs (9 h/d) compared with tiestalls and freestalls (10 to 12 h/d) in cross-farm research. Unfavorable conditions, including too few lying stalls for the number of cows, hard or wet lying surfaces, inadequate bedding, stalls that are too small or poorly designed, heat, and rain all reduce lying time. Time constraints, such as feeding or milking, can influence lying time. However, more information is needed about the implications of mediating factors such as the effect of the standing surface (concrete, pasture, or other surfaces) and cow behavior while standing (e.g., being restrained, walking, grazing) to understand the effect of low lying times on animal welfare. Many factors contribute to the difficulty of finding a valid threshold for daily lying time to use in the assessment of animal welfare. Although higher lying times often correspond with cow comfort, and lower lying times are seen in unfavorable conditions, exceptions occur, namely when cows lie down for longer because of disease or when they spend more time standing because of estrus or parturition, or to engage in other behaviors. In conclusion, lying behavior is important to dairy cattle, but caution and a full understanding of the context and the character of the animals in question is needed before drawing firm conclusions about animal welfare from measures of lying time.Peer reviewe

Vascular diseases in patients with chronic myeloproliferative neoplasms:Impact of comorbidity

Background: Patients with chronic myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), are at high risk of vascular complications. However, the magnitude of this is risk not well known and the possible effect of comorbidity is poorly understood. Aim: Our aim was to compare the risk of vascular diseases in patients with MPNs and matched comparisons from the general population and to study the effect modification of comorbidity. Methods: We followed 3087 patients with ET, 6076 with PV, 3719 with PMF or unspecified MPN, and age- and sex-matched general population comparisons to estimate the risks of cardiovascular diseases such as myocardial infarction and stroke. We computed 5-year cumulative incidences (risks) for vascular disease in patients with MPNs and comparisons as well as 1-year and 5-year risks, risk differences, and hazard ratios (HRs) for vascular diseases comparing rates in each group of patients with their comparison cohort by level of comorbidity based on the Charlson Comorbidity Index (CCI) [score of 0 (low comorbidity), of 1–2 (moderate comorbidity), and of >2 (severe comorbidity)], as well as other comorbid conditions. Results: The overall 5-year risk of vascular disease ranged from 0.5% to 7.7% in patients with MPNs, which was higher than the risk in the general population. In the same period, the adjusted HRs for vascular disease were 1.3 to 3.7 folds higher in patients with MPNs compared to the general population. An increase in CCI score was associated with an equally increased rate of most types of vascular diseases during the first 5 years of follow-up in both MPN and comparisons. Conclusion: Patients with MPNs have a higher risk of vascular diseases during the first 5 years than that of the general population; however, comorbidity modifies the rates similarly in MPN and in the general population

Criteria for the diagnosis of corticobasal degeneration

Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases from published reports and brain banks. Combined with consensus, 4 CBD phenotypes emerged: corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and progressive supranuclear palsy syndrome (PSPS). Clinical features of CBD cases were extracted from descriptions of 209 brain bank and published patients, providing a comprehensive description of CBD and correcting common misconceptions. Clinical CBD phenotypes and features were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies. Probable CBD criteria require insidious onset and gradual progression for at least 1 year, age at onset ≥50 years, no similar family history or known tau mutations, and a clinical phenotype of probable CBS or either FBS or naPPA with at least 1 CBS feature. The possible CBD category uses similar criteria but has no restrictions on age or family history, allows tau mutations, permits less rigorous phenotype fulfillment, and includes a PSPS phenotype. Future validation and refinement of the proposed criteria are needed

The Danish National Chronic Myeloid Neoplasia Registry

AIM: The Danish National Chronic Myeloid Neoplasia Registry (DCMR) is a population-based clinical quality database, introduced to evaluate diagnosis and treatment of patients with chronic myeloid malignancies. The aim is to monitor the clinical quality at the national, regional, and hospital departmental levels and serve as a platform for research. STUDY POPULATION: The DCMR has nationwide coverage and contains information on patients diagnosed at hematology departments from January 2010 onward, including patients with essential thrombocythemia, polycythemia vera, myelofibrosis, unclassifiable myeloproliferative neoplasms, chronic myelomonocytic leukemia, and chronic myeloid leukemia. MAIN VARIABLES: Data are collected using standardized registration forms (so far up to four forms per patient), which are consecutively filled out online at time of diagnosis, after 2-year and 5-year follow-ups, and at end of follow-up. The forms include variables that describe clinical/paraclinical assessments, treatment, disease progression, and survival – disease-specific variables – as well as variables that are identical for all chronic myeloid malignancies. DESCRIPTIVE DATA: By the end of 2014, the DCMR contained data on 2,690 patients with an inclusion rate of ∼500 patients each year. Since the registry was established, annual reports have shown consistently high national coverage and data completeness, ≥90% and ≥88%, respectively. CONCLUSION: The DCMR is a national database used for monitoring the quality of patient care in patients with chronic myeloid malignancies, but until validation has been conducted, the data must be used with caution. However, the DCMR is a valuable data source accessible to clinicians and researchers

La gestion alternative des eaux pluviales permet-elle une maîtrise efficace des flux de micropolluants? Retour d'expérience des projets Matriochkas, MicroMégas et Roulépur

Novatech 2019, LYON, FRANCE, 01-/07/2019 - 05/07/2019The pooling of results from three French projects (Matriochkas, MicroMégas and Roulépur), within the framework of a working group on methodological harmonisation, makes it possible to analyse the performance of a wide range of stormwater control measures (SCMs) in terms of micropollutant load reduction. Data covers 12 management systems, in 9 different urban contexts. The results highlight the diversity of runoff contamination levels and of their distribution between dissolved and particulate phases. They show significant reductions in particulate pollutants for all filtration-based systems, and less for those that only allow sedimentation. Performance is more limited for the dissolved phase, for which concentration reduction is limited and significant load reductions are only achieved due to a reduction in runoff volumes in structures promoting evapotranspiration.La mise en commun de résultats issus des projets français Matriochkas, MicroMégas et Roulépur, dans le cadre d'un groupe de travail d'échanges et d'harmonisation méthodologiques, permet d'analyser l'efficacité de la gestion alternative des eaux pluviales en termes de réduction des flux de micropolluants, pour 12 dispositifs de gestion et 9 contextes urbains différents. Les résultats soulignent la diversité des niveaux de contamination des eaux de ruissellement, et de leur distribution entre phases dissoutes et particulaires. Ils démontrent des abattements importants des polluants particulaires pour l'ensemble des systèmes basés sur la filtration, et moindre pour ceux ne permettant que la sédimentation. Les performances sont plus limitées pour les concentrations dissoutes, de sorte que seul un abattement des volumes de ruissellement, dans les ouvrages favorisant l'évapotranspiration, permet une réduction significative des flux de micropolluants dissou