NMR GHZ

We describe the creation of a Greenberger-Horne-Zeilinger (GHZ) state of the form |000>+|111> (three maximally entangled quantum bits) using Nuclear Magnetic Resonance (NMR). We have successfully carried out the experiment using the proton and carbon spins of trichloroethylene, and confirmed the result using state tomography. We have thus extended the space of entangled quantum states explored systematically to three quantum bits, an essential step for quantum computation.Comment: 4 pages in RevTex, 3 figures, the paper is also avalaible at http://qso.lanl.gov/qc

Development of self-repair nano-rod scaffold materials for implantation of osteosarcoma affected bone tissue

Osteosarcoma is the most widely recognized fatal bone disease in children and young adults. The osteosarcoma affected places of bone implant materials lose their activity after a period of time due to the possibility of regenerating sarcoma cells. Hence, the complete recovery of this disease is very challenging. Subsequently, new helpful methodologies, including natural antioxidant loaded bone implant materials, are effectively used to treat osteosarcoma cells. In this regard, nano-hydroxyapatite reinforced with a xylitol based poly(xylitol sebacate) PXS co-polymer together with a capsaicin loaded scaffold was investigated on osteosarcoma cells. The physicochemical properties of the scaffold were evaluated by FT-IR (Fourier transform infrared spectroscopy), SEM (scanning electron microscopy), TEM (transmission electron microscopy), and XRD (X-ray diffraction). The in vitro release and antioxidant activity of the capsaicin loaded nHAP/PXS/CAP scaffold were evaluated by UV-Visible spectroscopy. Cytotoxicity against the Saos-2 cancer line and cell viability in the osteoblast cell MG63 are reported. Eventually, the composite enlarges the creation of reactive oxygen species (ROS) in Saos-2 cells

RECAPITALIZATION AND ITS IMPACT ON BANK’S STABILITY, COMPETITIVENESS AND PROFITABILITY: EVIDENCE FROM INDIAN PSBs

There is a current argument relating to the capital infusion to the banks for strengthening capital on one side, without taking prudential measures to reduce the strains already present in the credit quality of banks on the other. The regulators thought that recapitalization of banks will be used to effectively reduce the cost of funds in the regular business provided when there is a higher lending demand. The capital infusion may turn out ineffective if there is less loan demand. On this background, this paper examines the effect of recapitalization of Indian public sector banks, and its impact on banks stability, competitiveness and profitability. Out of 21 banks, 18 banks reacted positively in case of one indicator, but failed in regard to overall indicators. Finally, the study reveals an interesting outcome that, there is no relationship between the size of the infusion and the performance of the bank. Hence, the study concludes that the capital infusion will help the banks significantly to improve the stability, competitiveness and profitability only when the banks’ fundamentals are strong, combined with the deployment of fresh funds and their managerial capability

Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection

Respiratory infections with Burkholderia cepacia complex (Bcc) bacteria in cystic fibrosis (CF) are associated with a worse prognosis and increased risk of death. In this work, we assessed the virulence potential of three B. cenocepacia clonal isolates obtained from a CF patient between the onset of infection (isolate IST439) and before death with cepacia syndrome 3.5 years later (isolate IST4113 followed by IST4134), based on their ability to invade epithelial cells and compromise epithelial monolayer integrity. The two clonal isolates retrieved during late-stage disease were significantly more virulent than IST439. Proteomic profiling by 2-D DIGE of the last isolate recovered before the patient's death, IST4134, and clonal isolate IST439, was performed and compared with a prior analysis of IST4113 vs. IST439. The cytoplasmic and membrane-associated enriched fractions were examined and 52 proteins were found to be similarly altered in the two last isolates compared with IST439. These proteins are involved in metabolic functions, nucleotide synthesis, translation and protein folding, cell envelope biogenesis and iron homeostasis. Results are suggestive of the important role played by metabolic reprogramming in the virulence potential and persistence of B. cenocepacia, in particular regarding bacterial adaptation to microaerophilic conditions. Also, the content of the virulence determinant AidA was higher in the last 2 isolates. Significant levels of siderophores were found to be secreted by the three clonal isolates in an iron-depleted environment, but the two late isolates were more tolerant to low iron concentrations than IST439, consistent with the relative abundance of proteins involved in iron uptake.This work was supported by FEDER and FCT – Fundação para a Ciência e a Tecnologia (contract PEst-OE/EQB/LA0023/2011_ research line: Systems and Synthetic Biology; PhD grant to A.M. – SFRH/BD/37012/2007, and PD grants to S.S. – SFRH/BPD/75483/2010 and C.C. – SFRH/BPD/ 81220/2011. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersio

BAT3 Guides Misfolded Glycoproteins Out of the Endoplasmic Reticulum

Secretory and membrane proteins that fail to acquire their native conformation within the lumen of the Endoplasmic Reticulum (ER) are usually targeted for ubiquitin-dependent degradation by the proteasome. How partially folded polypeptides are kept from aggregation once ejected from the ER into the cytosol is not known. We show that BAT3, a cytosolic chaperone, is recruited to the site of dislocation through its interaction with Derlin2. Furthermore, we observe cytoplasmic BAT3 in a complex with a polypeptide that originates in the ER as a glycoprotein, an interaction that depends on the cytosolic disposition of both, visualized even in the absence of proteasomal inhibition. Cells depleted of BAT3 fail to degrade an established dislocation substrate. We thus implicate a cytosolic chaperone as an active participant in the dislocation of ER glycoproteins.United States. National Institutes of HealthBoehringer Ingelheim Fond

Prevalence and determinants of Otitis Media in children 1 to 6 years of age: An analytical cross-sectional study

Objectives: The aim of the present study was to determine the prevalence of Otitis Media; and to assess the risk factors for Otitis media in children aged one to six years of age. Methods: This was an analytical cross-sectional study conducted in the Rural Field Practice Area (RFPA) of a tertiary healthcare facility in north India between September 2018 and December 2019. Children in the age group of 1 to 6 years presenting with acute suppurative otitis media, or sequelae of acute otitis media including Otitis media with effusion and chronic otitis media were considered as cases of Otitis media. Results: The overall prevalence rate of Otitis media was found to be 12.7%. Regarding the distribution of types of Otitis media, it was found that 36.8% had Otitis media with effusion, 34.2% had eustachian tube catarrh, 21.1% had Chronic suppurative otitis media – Tubotympanic disease (CSOM-TTD), and 7.9% had Acute suppurative otitis media (ASOM), in that order. We found that age less than three years (or 36 months) (OR 2.86, 95% CI 1.92 to 3.45); living in a kutcha house (OR 1.91, 95% CI 1.04 to 3.74); malnutrition, that is weight for age <-2SD from reference median (OR 3.18, 95% CI 1.76 to 5.58); breastfeeding for less than six months (OR 2.24, 95% CI 1.30 to 4.88); and persistent rhinorrhoea (OR 2.78, 95% CI 1.56 to 4.33) were significant predictors of Otitis media among children one to six years of age (p<0.05). Conclusion: Efforts should focus on improving housing conditions, promoting breastfeeding practices, addressing malnutrition, and managing respiratory symptoms effectively

Cochlear implantation surgery in prelingually deaf children – Hearing and speech outcomes

Objectives: The objective of the present study was to assess the hearing and speech outcomes of prelingually deaf children who underwent cochlear implantation surgery in a tertiary healthcare facility; disaggregated by age and gender. Methods: This was an observational prospective study conducted in the Department of Paediatrics and Otorhinolaryngology of a tertiary healthcare facility in western India between June 2019 and May 2020. We enrolled all children between 1 and 6 years of age with bilaterally prelingual deafness (with no benefit using bearing aid) who underwent cochlear implantation surgery at the tertiary healthcare facility. Results: The results showed that the Categories of Auditory Performance (CAP) scale score (MD 1.52, 95% CI 1.24 to 1.80), Meaningful Auditory Integration Scale (MAIS) scores (MD 7.51, 95% CI 5.59 to 9.42), Speech Intelligibility Rating Scale (SIR) scores (MD 1.68, 95% CI 1.37 to 1.99), and Meaningful Use of Speech Scale (MUSS) scores (MD 9.02, 95% CI 7.59 to 10.45) significantly (p0.05). Conclusion: The findings indicate that younger children (1-3 years) tend to achieve better outcomes compared to older children (3-6 years) highlighting the importance of early cochlear implantation for optimizing auditory performance, better speech intelligibility and meaningful auditory integration in prelingually deaf children

Stochastic Models on Time to Recruitment in a Two Grade Manpower System using Different Policies of Recruitment

In this paper a two grade organization in which depletion of manpower occurs due to its policy decisions is considered. Two mathematical models are constructed employing two different univariate recruitment policies, based on shock model approach. The mean and variance of the time to recruitment are obtained for both the models under different conditions. The analytical results are numerically illustrated and relevant conclusions are presented

Mean and Variance of the Time to Recruitment in a Two Graded Manpower System with Two Thresholds for the Organization

In this paper, a two graded manpower system which is subject to exit of personnel due to the policy decisions taken in the system is considered. There is an associated loss of manpower if a person quits. As the exit of personnel is unpredictable, a new recruitment policy involving two thresholds – one is optional and the other one mandatory is suggested to enable the organization to plan its decision on recruitment. Based on shock model approach, two mathematical models are constructed using a univariate policy of recruitment. The analytical expression for the mean and variance of the time to recruitment are obtained when i) the loss of manpower processes in grades 1& 2 form separately a sequence of independent and identically distributed exponential random variables ii) the inter-decision times are independent and identically distributed exponential random variables and iii) the optional and mandatory thresholds in both the grades follow exponential, exponentiated exponential distribution and the distribution having SCBZ property respectively. The results are numerically illustrated for both the models and relevant conclusions are made. ÂÂ