Redesain Kompleks Gereja Katedral Keuskupan Agung Palembang

Church of Santa Maria designated as the Cathedral as there are Cehedral (Bishop Throne). Over time, the number in the parish of Santa Maria continues to grow. Until now, the church building was 59 years old and already inadequate to support the religious activities of Catholics in the parish of Santa Maria. Therefore, it is necessary to design and redesign the Cathedral Complex is equipped with chambers supporting activities. In addition, forward planning, necessary to expand the site for adequate arrangement of parking space, so that the Church of Santa Maria can be the center of spiritual activities, and reduce the level of traffic jam that interfere with the activiies of the surrounding people. With the theme of “Simplicity and Majesty of The Most High”, and use the Neo-Gothic style, the cathedral is expected able to accommodate all spiritual activities, both in the parish until the Archdiocese of Palembang level

Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection

Introduction: Peripheral blood (PB) molecular patterns characterizing the different effector immune pathways driving distinct kidney rejection types remain to be fully elucidated. We hypothesized that transcriptome analysis using RNA sequencing (RNAseq) in samples of kidney transplant patients would enable the identification of unique protein-coding and noncoding genes that may be able to segregate different rejection phenotypes. Methods: We evaluated 37 biopsy-paired PB samples from the discovery cohort, with stable (STA), antibody-mediated rejection (AMR), and T cell-mediated rejection (TCMR) by RNAseq. Advanced machine learning tools were used to perform 3-way differential gene expression analysis to identify gene signatures associated with rejection. We then performed functional in silico analysis and validation by Fluidigm (San Francisco, CA) in 62 samples from 2 independent kidney transplant cohorts. Results: We found 102 genes (63 coding genes and 39 noncoding genes) associated with AMR (54 upregulated), TCMR (23 upregulated), and STA (25 upregulated) perfectly clustered with each rejection phenotype and highly correlated with main histologic lesions (r = 0.91). For the genes associated with AMR, we found enrichment in regulation of endoplasmic reticulum stress, adaptive immunity, and Ig class-switching. In the validation, we found that the SIGLEC17P pseudogene and 9 SIGLEC17P-related coding genes were highly expressed among AMR but not in TCMR and STA samples. Conclusions: This analysis identifies a critical gene signature in PB in kidney transplant patients undergoing AMR, sufficient to differentiate them from patients with TCMR and immunologically quiescent kidney allografts. Our findings provide the basis for new studies dissecting the role of noncoding genes in the pathophysiology of kidney allograft rejection and their potential value as noninvasive biomarkers of the rejection process

ANALISIS BIAYA MUTU PADA MEBEL BERDIKARI TAHUN 2011 – 2015

Industri kayu saat ini sedang mengalami persaingan bisnis yang pesat. Hal ini ditunjukkan melalui munculnya industri-industri sejenis yang memiliki keunggulan-keunggulan seperti penawaran harga yang murah, desain furniture yang unik serta relasi perusahaan dengan pelanggan. Sehingga perusahaan harus selalu memperhatikan mutu produk yang diproduksi. Perusahaan yang menghasilkan produk dengan mutu baik harus melakukan beberapa aktivitas. Aktivitas yang dilakukan perusahaan untuk menghasilkan produk bermutu adalah aktivitas pencegahan, aktivitas penilaian, aktivitas kegagalan internal dan aktivitas kegagalan eskternal. Aktivitas berkait mutu yang dilakukan menyebabkan perusahaan harus mengeluarkan biaya. Biaya yang berkaitan dengan mutu tersebut disebut dengan biaya mutu. Penelitian ini dilakukan dengan tujuan untuk mengetahui total biaya mutu pada Mebel Berdikari tahun 2015 – 2017 dan mengetahui efektivitas biaya mutu yang dikeluarkan Mebel Berdikari pada tahun 2015 – 2017. Hasil penelitian menunjukkan bahwa biaya mutu pada Mebel Berdikari tahun 2015 adalah Rp. 30.702.373. Biaya mutu pada Mebel Berdikari tahun 2016 adalah Rp. 31.258.714. Biaya mutu pada Mebel Berdikari tahun 2017 adalah Rp. 32.954.246.Biaya mutu pada tahun 2016 dan 2017 belum efektif karena persentase kenaikan biaya pengendalian lebih besar dari persentase penurunan biaya kegagalan