Room temperature co-precipitation synthesis of magnetite nanoparticles in a large pH window with different bases

pre-printMagnetite nanoparticles (Fe3O4) represent the most promising materials in medical applications. To favor high-drug or enzyme loading on the nanoparticles, they are incorporated into mesoporous materials to form a hybrid support with the consequent reduction of magnetization saturation. The direct synthesis of mesoporous structures appears to be of interest. To this end, magnetite nanoparticles have been synthesized using a one pot co-precipitation reaction at room temperature in the presence of different bases, such as NaOH, KOH or (C2H5)4NOH. Magnetite shows characteristics of superparamagnetism at room temperature and a saturation magnetization (Ms) value depending on both the crystal size and the degree of agglomeration of individual nanoparticles. Such agglomeration appears to be responsible for the formation of mesoporous structures, which are affected by the pH, the nature of alkali, the slow or fast addition of alkaline solution and the drying modality of synthesized powders

Care Network Coordination for Chemotherapy at Home: A Case Study

International audienceThis paper deals with a system of chemotherapy at home which is managed by a Home Care Services (HCS) structure. The main role of this HCS structure is to coordinate care actors for a smooth organization of chemotherapy at home. In this work, we model a real system of chemotherapy at home managed by a HCS structure, and simulate its behaviour. The objective is to evaluate the relevance of such a system for current activities of the HCS structure, and to propose solutions for improving the optimal coordination of the care network for chemotherapy at home

Macrozoobenthos e decomposizione fogliare in ecosistemi fluviali sardi: prime considerazioni sul fiume Silis (Sardegna Settentrionale)

The purposes of this research were to examine and compare the breakdown rates of one specie (Ulmus minor) of tree leaves at three sites along Silis River (Northern Sardinia) and to follow macroinvertebrate leaf colonization, focusing our attention on the values of abundance, biomass and density of macrozoobenthos and its functional groups, based on feeding mechanism. About macroinvertebrate analysis, the organisms of shredder functional group showed the highest biomass for all the three sites examined, according to the fast decay coefficients. On the three sites studied macroinvertebrate communities proved themselves to become slightly different as a result of an increasing number of collectors from the upstream site 1 to the downstream site 3 according to the theory of the River Continuum Concept

Experimental Evidence of the Effectiveness and Applicability of Colloidal Nanosilica Grouting for Liquefaction Mitigation

AbstractThe low viscosity and the ability to control solidification rate make colloidal nanosilica grout an excellent ground-improvement solution which is functional for different engineering purpo..

Use of path algebra tools for a unified description of a large class of pull control policies

International audienceMany pull policies can be found in the literature for controlling multistage production/inventory systems. In this paper, we present a framework that enables us to describe the dynamics of a large class of pull control policies, using the same set of canonical functions. The class of policies we consider here include well known pull policies, like kanban, CONWIP, basestock, generalized kanban, extended kanban, but also many other hybrid policies, and their extensions to systems producing batches. Each of these policies is characterized by the values of some parameters. These parameters values are calculated thanks to a computational algorithm that relies on the use of path algebra tools, especially (min,+) algebra tools. This canonical formulation allows to identify under which values of the control parameters, two different policies have the same dynamics behavior. It also enables to derive methods for evaluating and comparing the performance of several pull control policies, as we illustrate it in the paper

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching

Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial. However, the mechanisms underlying the efficacy of bindarit in controlling neointimal formation/restenosis have not been fully elucidated. Therefore, we investigated the effect of bindarit on human coronary smooth muscle cells activation, drawing attention to the phenotypic modulation process, focusing on contractile proteins expression as well as proliferation and migration. The expression of contractile proteins was evaluated by western blot analysis on cultured human coronary smooth muscle cells stimulated with TNF-α (30 ng/mL) or fetal bovine serum (5%). Bindarit (100-300 µM) reduced the embryonic form of smooth muscle myosin heavy chain while increased smooth muscle α-actin and calponin in both TNF-α- and fetal bovine serum-stimulated cells. These effects were associated with the inhibition of human coronary smooth muscle cell proliferation/migration and both MCP-1 and MCP-3 production. The effect of bindarit on smooth muscle cells phenotypic switching was confirmed in vivo in the rat balloon angioplasty model. Bindarit (200 mg/Kg/day) significantly reduced the expression of the embryonic form of smooth muscle myosin heavy chain, and increased smooth muscle α-actin and calponin in the rat carodid arteries subjected to endothelial denudation. Our results demonstrate that bindarit induces the differentiated state of human coronary smooth muscle cells, suggesting a novel underlying mechanisms by which this drug inhibits neointimal formation

Aide au pilotage de la chaîne de prise en charge de la chimiothérapie à domicile

Le sujet de thèse s intéresse à la chimiothérapie à domicile qui est l effet combiné de l augmentation des patients atteints du cancer et du succès de l hospitalisation à domicile. Nous proposons à travers ce mémoire de thèse des solutions appropriées au pilotage de la chaîne de prise en charge de la chimiothérapie à domicile permettant d évaluer et d améliorer la performance de celle-ci. La première partie présente le contexte socio-économique de la chimiothérapie à domicile, ainsi que les contraintes réglementaires et organisationnelles pour sa mise en œuvre. La deuxième partie précise les spécificités d une chaîne de prise en charge de la chimiothérapie à domicile et les problématiques liées à cette chaîne basée sur une revue de la littérature. La troisième partie se focalise sur la modélisation des processus de prise en charge de la chimiothérapie à domicile à partir d un important travail de terrain. Un modèle générique de la chimiothérapie à domicile est dégagé du travail de modélisation qui constitue le fondement d une proposition de classification des pratiques de la chimiothérapie à domicile. Un diagnostic individuel et comparatif des différentes familles d approches sont également présentés dans cette partie. La quatrième partie présente les différentes applications développées pour évaluer et améliorer la performance de la chaîne de prise en charge de la chimiothérapie à domicile. En conclusion, cette thèse apporte une première contribution à la généralisation de la pratique de la chimiothérapie à domicile et au développement d outils d aide aux pilotages destinés à l amélioration de sa réalisationThis thesis deals with chemotherapy at home which is the fruit of increasing cancer patients and successful development of home care services. We present in this thesis appropriate solutions to evaluate and improve management performance of chemotherapy at home network. The first part concerns the socioeconomic context of chemotherapy at home, as well as its legal and organizational constraints. The second part outlines specificities and related issues of chemotherapy at home based on a literature review. The third part focuses on chemotherapy at home process modeling depending on an important field work. A generic model of chemotherapy at home is abstracted, which is the basis of a chemotherapy at home practices classification that we proposed. An individual analysis and a comparative analysis of chemotherapy at home approaches are also proposed in this part. The fourth part presents different solutions that we developed to evaluate and improve the management performance of chemotherapy at home network. In conclusion, this thesis provides an initial contribution to promote chemotherapy at home practices and to develop management support tools for its implementationST ETIENNE-Bib. électronique (422189901) / SudocSudocFranceF

Strength of sandy and clayey soils cemented with single and double fluid jet grouting

Abstract Innovations in jet grouting technology have primarily focused on the cutting efficiency of the jets, with the aim of creating larger columns and increasing the productivity of construction sites. Relatively little attention has been paid to the consequences of the grouting system on the mechanical properties of the formed material. This paper investigates this aspect by analysing the results of two field trials carried out in both sandy and clayey soils, where single and double fluid jet grouting were simultaneously performed, with varied grout composition and injection parameters. Parallel uniaxial compressive tests on samples cored from the columns show that the material formed with the double system is systematically lower in strength than the material formed using the single fluid system. The mineralogical composition of samples cored from the columns was analysed by performing parallel Scanning Electron Microscopy (SEM), X-ray diffraction analysis (XRD), Differential Thermal Analysis (DTA) and Thermo-Gravimetric Analyses (TGA) to determine the reasons for this difference. A lower proportion of cementitious products, an accelerated carbonation of portlandite and a less homogeneous distribution of cement hydration products was found on the surface of the soil particles of the double samples than for the single fluid columns