RELATO DE EXPERIÊNCIA: trabalhando a diversidade étnica-racial na educação infantil

O presente trabalho trata de um relato de experiência que foi vivenciado no Colégio Deus Menino, no município de Santa Quitéria do Maranhão – MA, com crianças de 1º período de 3 anos de idade. Tendo por objetivo geral apresentar atividades didáticas que trabalhem as diversidades étnicas-raciais, conduzindo os educandos em fase inicial da educação básica um olhar mais amplo para pluralidade cultural, como a diversidade de etnias, raças e reconhecimento de seus traços físicos como parte de sua historicidade enquanto pessoa humana. De modo que as atividades propostas partiram da data escolhida, dia 20 de novembro, Dia da consciência negra, para reflexão da temática abordada e a obra de Ana Maria Machado, Menina Bonita do laço de fita, como fio norteador e motivador para trabalhar também a identidade e representatividade da criança negra, no intuindo de construir e reconstruir significações no processo de reconhecimento identitário da criança para formação ainda que inicial de um cidadão crítico e reflexivo que se posiciona e dialoga com as diferentes relações humanas. Utilizando de metodologia de natureza exploratória e abordagem qualitativa para elaboração desse trabalho que visa estimular a construção e reflexão de novas práticas e métodos de ensino que contribuam no desenvolvimento na qualidade da educação e que estimulem o diálogo e uma postura ética e mais igualitária na formação social do educando. Assim as atividades propostas foram bastante proveitosas e satisfatórias pois foi possível promover um alargamento de conhecimentos sobre as diversidades étnicas-raciais

ANÁLISE DAS EXPORTAÇÕES DE MILHO EM GRÃO DO ESTADO DE MATO GROSSO NO PERÍODO DE 2001 A 2010

O objetivo do estudo foi analisar as exportações de milho do Estado de Mato Grosso no período compreendido entre 2001 a 2010, com o intuito de verificar se houve acréscimo ou decréscimo nas exportações do mesmo. A pesquisa foi classificada como descritiva e com abordagem quantitativa, foi conduzida por meio de coleta de dados secundários obtidos no Ministério de Desenvolvimento, Indústria e Comércio Exterior – MDIC. Os resultados revelam que as exportações do Estado evoluíram no decorrer do período analisado, levando o Estado ser o principal exportador de milho do país desde 2008 superando, portanto, o Estado do Paraná. Infere-se que a exportação de milho de Mato Grosso possui potencial para continuar expandindo tanto em volume quanto em valor exportado, uma vez que tem muita aceitabilidade no mercado externo

An enzymatic route to a benzocarbazole framework using bacterial CotA laccase

The CotA laccase-catalysed oxidation of the meta, para-disubstituted arylamine 2,4-diaminophenyldiamine delivers, under mild reaction conditions, a benzocarbazole derivative (1) (74% yield), a key structural motif of a diverse range of applications. This work extends the scope of aromatic frameworks obtained using these enzymes and represents a new efficient and clean method to construct in one step C-C and C-N bonds

Antiproliferative Effects of the Natural Oxadiazine Nocuolin A Are Associated With Impairment of Mitochondrial Oxidative Phosphorylation

Natural products are interesting sources for drug discovery. The natural product oxadiazine Nocuolin A (NocA) was previously isolated from the cyanobacterial strain Nodularia sp. LEGE 06071 and here we examined its cytotoxic effects against different strains of the colon cancer cell line HCT116 and the immortalized epithelial cell line hTERT RPE-1. NocA was cytotoxic against colon cancer cells and immortalized cells under conditions of exponential growth but was only weakly active against non-proliferating immortalized cells. NocA induced apoptosis by mechanism(s) resistant to overexpression of BCL family members. Interestingly, NocA affected viability and induced apoptosis of HCT116 cells grown as multicellular spheroids. Analysis of transcriptome profiles did not match signatures to any known compounds in CMap but indicated stress responses and induction of cell starvation. Evidence for autophagy was observed, and a decrease in various mitochondrial respiration parameter within 1 h of treatment. These results are consistent with previous findings showing that nutritionally compromised cells in spheroids are sensitive to impairment of mitochondrial energy production due to limited metabolic plasticity. We conclude that the antiproliferative effects of NocA are associated with effects on mitochondrial oxidative phosphorylation

A natural oxadiazine isolated from cyanobacteria kills cancer cells in multicellular culture systems by impairing cellular respiration

Cyanobacteria are versatile microorganisms that ubiquitously inhabit terrestrial and aquatic ecosystems. They adapt to external threats by mainly producing secondary metabolites. Therefore, cyanobacteria have been recognized as producer of natural products with potential biotechnological applications, such as bioplastics, antifouling, antibiotics, antiprotozoal or anticancer treatment.info:eu-repo/semantics/publishedVersio

Six bacterial vaginosis-associated species can form an in vitro and ex vivo polymicrobial biofilm that is susceptible to Thymbra capitata essential oil

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcimb.2022.824860/full#supplementary-materialBacterial vaginosis (BV) is associated with serious gynaecologic and obstetric complications. The hallmark of BV is the presence of a polymicrobial biofilm on the vaginal epithelium, but BV aetiology is still a matter of debate. We have previously developed an in vitro biofilm model that included three BV-associated species, but, up to now, no studies are available whereby more bacterial species are grown together to better mimic the in vivo situation. Herein, we characterized the first polymicrobial BV biofilm consisting of six cultivable BV-associated species by using both in vitro and ex vivo vaginal tissue models. Both models revealed that the six species were able to incorporate the polymicrobial biofilm, at different bacterial concentrations. As it has been thought that this polymicrobial biofilm may increase the survival of BV-associated species when exposed to antibiotics, we also assessed if the Thymbra capitata essential oil (EO), which has recently been shown to be highly bactericidal against several Gardnerella species, could maintain its anti-biofilm activity against this polymicrobial biofilm. Under our experimental conditions, T. capitata EO exhibited a high antibacterial effect against polymicrobial biofilms, in both tested models, with a significant reduction in the biofilm biomass and the number of culturable cells. Overall, this study shows that six BV-associated species can grow together and form a biofilm both in vitro and when using an ex vivo model. Moreover, the data obtained herein should be considered in further applications of T. capitata EO as an antimicrobial agent fighting BV.This work was supported by the Portuguese Foundation for Science and Technology (FCT) by the research project [PTDC/BIA-MIC/28271/2017] under the scope of COMPETE 2020 [POCI-01-0145-FEDER-028271] and by the strategic funding of unit [UID/BIO/04469/2020]. ASR acknowledges the support of FCT individual fellowship [PD/BD/128037/2016]. The founder had no role in the study design and collection, analysis, and interpretation of the results.info:eu-repo/semantics/publishedVersio

Automatic program reports

To profit from the data collected by the SIGARRA academic IS, a systematic setof graphs and statistics has been added to it and are available on-line. Thisanalytic information can be automatically included in a flexible yearly report foreach program as well as in a synthesis report for the whole school. Somedifficulties in the interpretation of some graphs led to the definition of new keyindicators and the development of a data warehouse across the university whereeffective data consolidation is obtained

Study of influence of granulometry of cactus pear forage (Opuntia fícus) bark biomass on removal of organic contaminants in water bodies by differential bed adsorption technique / Estudo da influência da granulometria da biomassa da casca da palma forrageira (Opuntia fícus) na remoção de contaminantes orgânicos em corpos d'água por técnica de adsorção diferencial em leito

Petroleum exploration oil has caused accidents that end up contaminating environment. Adsorption process has been shown to be an effective and economical method in treatment of effluents with organic compounds. Use of biomass as adsorbent has been a potentially and economical alternative for treatment of various types of effluents. Therefore, objective of this work was to study influence of biomass granulometry in differential bed adsorption process, using as biosorbent cactus pear forage bark (Opuntia fícus), typical species of northeastern semiarid, to remove gasoline in water bodies. Methodology used was proposed by Lima et al. (2014). Initially, biomass was prepared in particulate form in three different particle sizes (meshs 07, 10 and 18). Subsequently, experiments were performed to study adsorption kinetics, in which times from 05 to 60 minutes were evaluated and adsorption equilibrium, whose contaminant concentrations ranged from 5 to 60%. For differential bed, concentrations of 5%, 7.5% and 10% were used. Results confirmed that gasoline adsorption kinetics by biomass was fast in all granulometries, but its influence was not significant. Equilibrium isotherms also showed maximum adsorption capacity values close to each other for three particle sizes. In differential bed system, three different particle sizes presented significant adsorption capacity, and particle size, smaller than 1 mm resulted in higher contaminant adsorption. From results, it can be confirmed that cactus pear forage bark presents as an adsorbent biomass for removal gasoline present in water bodies and that small grain size variations do not significantly affect adsorption process