Profile of cancer patients requiring dental and oral-maxillofacial prostheses in a Brazilian subpopulation

The aim of the present study was to identify the profile of cancer patients in need of rehabilitation with dental and/or oral-maxillofacial prostheses and evaluate possible reasons for not concluding the rehabilitation process. A retrospective observati

Evaluation of the standardization of injection dental needles marketed in Brazil

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOThe standardization of sterile, single-use dental injection needles marketed in Brazil in 1997 was evaluated. The effective needle length (L1), butt end length (L2), socket depth (L3), external (ED) and internal (ID) diameters, corrosion resistance of the cannula, and the information printed on the package (unitary protector and box) were evaluated. The data were compared with the International Standard (ISO), American specification no. 54 (ANSI/ADA) and French Standard (FS). There were great variations for L1, L2, L3 and ID, and no trade mark fitted in any of the standards for all the dimensions. The external diameter showed very little variation in all the trade marks according to the ANSI/ADA and FS. All of the needles withstood the corrosion test. Some trade marks had incomplete information in their package and one of them had no expiration date. Some of the unitary protectors, once opened, did not show clear evidence of having been violated. These results show the need for a Brazilian specification to regulate the manufacturing of single-use dental injection needles.Foram avaliadas neste trabalho agulhas anestésicas odontológicas descartáveis, comercializadas no Brasil no segundo semestre de 1997, quanto às medidas: comprimento da cânula, da porção que perfura o tubete e da porção que permanece no interior do adaptador plástico e diâmetros externo e interno. A resistência à corrosão da cânula e as informações da embalagem (caixa e protetor) também foram avaliadas. Os resultados foram comparados com as normas Internacional (ISO)8, Americana (ANSI/ADA)¹ e Francesa (NF). Foram observadas variações, não havendo uma só marca que estivesse de acordo com qualquer das normas, para todas as medidas. Todas as agulhas atingiram as especificações do teste de corrosão. Algumas embalagens mostraram conteúdo de informação incompleto e uma marca estava sendo vendida sem prazo de validade. Alguns protetores não permitiam identificar a violação do lacre, quando isto ocorria. Estes resultados demonstram a necessidade de se estabelecerem normas brasileiras, para regulamentar a produção e venda de agulhas odontológicas no país143294299CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO136992/96-0The standardization of sterile, single-use dental injection needles marketed in Brazil in 1997 was evaluated. The effective needle length (L1), butt end length (L2), socket depth (L3), external (ED) and internal (ID) diameters, corrosion resistance of the cannula, and the information printed on the package (unitary protector and box) were evaluated. The data were compared with the International Standard (ISO), American specification no. 54 (ANSI/ADA) and French Standard (FS). There were great variations for L1, L2, L3 and ID, and no trade mark fitted in any of the standards for all the dimensions. The external diameter showed very little variation in all the trade marks according to the ANSI/ADA and FS. All of the needles withstood the corrosion test. Some trade marks had incomplete information in their package and one of them had no expiration date. Some of the unitary protectors, once opened, did not show clear evidence of having been violated. These results show the need for a Brazilian specification to regulate the manufacturing of single-use dental injection needle

Avaliação da padronização de agulhas anestésicas odontológicas comercializadas no Brasil

The standardization of sterile, single-use dental injection needles marketed in Brazil in 1997 was evaluated. The effective needle length (L1), butt end length (L2), socket depth (L3), external (ED) and internal (ID) diameters, corrosion resistance of the cannula, and the information printed on the package (unitary protector and box) were evaluated. The data were compared with the International Standard (ISO), American specification no. 54 (ANSI/ADA) and French Standard (FS). There were great variations for L1, L2, L3 and ID, and no trade mark fitted in any of the standards for all the dimensions. The external diameter showed very little variation in all the trade marks according to the ANSI/ADA and FS. All of the needles withstood the corrosion test. Some trade marks had incomplete information in their package and one of them had no expiration date. Some of the unitary protectors, once opened, did not show clear evidence of having been violated. These results show the need for a Brazilian specification to regulate the manufacturing of single-use dental injection needles.Foram avaliadas neste trabalho agulhas anestésicas odontológicas descartáveis, comercializadas no Brasil no segundo semestre de 1997, quanto às medidas: comprimento da cânula, da porção que perfura o tubete e da porção que permanece no interior do adaptador plástico e diâmetros externo e interno. A resistência à corrosão da cânula e as informações da embalagem (caixa e protetor) também foram avaliadas. Os resultados foram comparados com as normas Internacional (ISO)8, Americana (ANSI/ADA)¹ e Francesa (NF). Foram observadas variações, não havendo uma só marca que estivesse de acordo com qualquer das normas, para todas as medidas. Todas as agulhas atingiram as especificações do teste de corrosão. Algumas embalagens mostraram conteúdo de informação incompleto e uma marca estava sendo vendida sem prazo de validade. Alguns protetores não permitiam identificar a violação do lacre, quando isto ocorria. Estes resultados demonstram a necessidade de se estabelecerem normas brasileiras, para regulamentar a produção e venda de agulhas odontológicas no país

Atitudes de estudantes de enfermagem frente ao usuário de substâncias e percepções sobre o cuidado religioso/espiritual

Objective: To evaluate the impact of an educational intervention on the attitudes of Nursing students towards users of psychoactive substances (excluding alcohol and tobacco) and their perceptions about the religious and spiritual care offered within the health services. Method: Quasi-experimental study. We applied a questionnaire before and one month after an intervention about the comprehensive care of substance users, containing: sociodemographic information, knowledge, the Treatment Spirituality/ Religiosity Scale, and the Drug and Drug Problems Perceptions Questionnaire. For the analyses, we employed the paired Student’s t-test and Pearson’s Coefficient. Results: 62 students participated in this study. After the intervention, there was improvement in the students’ attitudes towards the substance users, but not regarding the perception they already had about the importance of offering religious and spiritual care within the services. Conclusion: We verified the effectiveness of the educational intervention on the improvement of attitudes concerning the care of substance users, yet we point out that the students did not show changes in their perception about the inclusion of the religious and spiritual aspects in the care dedicated to this population

The influence of local anesthetic solutions storage on tissue inflammatory reaction

Objective: This study aimed to analyze the influence of storage conditions of local anesthetic solutions in the inflammatory reaction after injection in rats. Study design: Twenty-four rats received in their oral mucosa the injection of 2% lidocaine with epinephrine 1:100.000 solutions (LA) submitted to the following storage conditions during a twelve-month period: G1 - inside the original packaging, in refrigerator (5±1°C); G2 - inside the original box, under light shelter, at room temperature; G3 - outside the original box at room temperature (exposed to artificial light for 12 hours/day) and G4 - brand new solution. For the controls tests, 0.9% sodium chloride solution was injected in the opposite side. After 6 and 24 hours, three animals of each group were sacrificed and their maxilla along with the soft tissue were removed and submitted to histological analysis (HE). Results: The pH of LA was measured before and after the storage period and no statistically differences were observed between G1 and G4, but both were different from G2 and G3. All the scores of the testing solutions were higher than their respective negative controls, except for G1 at 6 hours. The order of the scores of inflammation after 6 hours was G3>G4>G2=G1. After 24 hours the order was G3>G2>G1>G4. Conclusion: The study showed that the method of storage can influence the pH and the level of inflammatory reaction after the injection of 2% lidocaine with epinephrine 1:100.000

The Effects of N

Leishmaniasis is a disease that affects millions of people worldwide. The drugs that are available for the treatment of this infection exhibit high toxicity and various side effects. Several studies have focused on the development of new chemotherapeutic agents that are less toxic and more effective against trypanosomatids. We investigated the effects of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide (C4) and its possible targets against L. amazonensis. The results showed morphological and ultrastructural alterations, depolarization of the mitochondrial membrane, the loss of cell membrane integrity, and an increase in the formation of mitochondrial superoxide anions in L. amazonensis treated with C4. Our results indicate that C4 is a selective antileishmanial agent, and its effects appear to be mediated by mitochondrial dysfunction

Methylparaben concentration in commercial Brazilian local anesthetics solutions

OBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for use in dentistry were purchased from the Brazilian market and analyzed. Different lots of the commercial brands were obtained in different Brazilian cities (Piracicaba, Campinas and São Paulo). Separation was performed using high performance liquid chromatography (HPLC) with UV-Vis detector. The mobile phase used was acetonitrile:water (75:25 - v/v), pH 4.5, adjusted with acetic acid at a flow rate of 1.0 ml.min-1. RESULTS: When detected in the solutions, the methylparaben concentration ranged from 0.01% (m/v) to 0.16% (m/v). One glass and all plastic cartridges presented methylparaben. CONCLUSION: 1. Methylparaben concentration varied among solutions from different manufacturers, and it was not indicated in the drug package inserts; 2. Since the presence of methylparaben in dental anesthetics is not regulated by the Brazilian National Health Surveillance Agency (ANVISA) and this substance could cause allergic reactions, it is important to alert dentists about its possible presence

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study

Background: This study analyzes the effect of frailty and Post-Operative Delirium (POD) on the functional status at hospital discharge and at 4-month follow-up in patients with hip fracture (HF). Methods: Multicenter prospective observational study of older patients with HF admitted to 12 Italian Orthogeriatric centers (July 2019-August 2022). POD was assessed using the 4AT. A 26-item Frailty Index (FI) was created using data collected on admission. The outcome measures were Cumulated Ambulation Score (CAS) ≤ 2 at discharge and a telephone-administered CAS ≤ 2 after 4 months. Poisson regression models were used to assess the effect of frailty and POD on outcomes. Results: 984 patients (median age 84 years, IQR = 79-89) were recruited: 480 (48.7%) were frail at admission, 311 (31.6%) developed POD, and 158 (15.6%) had both frailty and POD. In a robust Poisson regression, frailty alone (Relative Risk, RR = 1.56, 95% Confidence Intervals, CI 1.19-2.04, p = 0.001) and its combination with POD (RR = 2.57, 95% CI 2.02-3.26, p < 0.001) were associated with poor functional status at discharge. At 4-month follow-up, the combination of frailty with POD (RR 3.65, 95% CI 1.85-7.2, p < 0.001) increased the risk of poor outcome more than frailty alone (RR 2.38, 95% CI 1.21-4.66, p < 0.001). Conclusions: POD development exacerbates the negative effect that frailty exerts on functional outcomes in HF patients

DESENVOLVIMENTO SUSTENTÁVEL EM CABO VERDE

Tendo como tripé os fatores econômicos, sociais e ambientais, o Desenvolvimento Sustentável viabiliza suprir as necessidades básicas das gerações presentes sem comprometer a sobrevivência das demais gerações, ou seja, isso será possível se tiver a qualidade ambiental e com a renovação do estoque dos recursos (BECKER; MIRANDA, 1997). Desta forma, abordar o elo que existe entre as políticas públicas adotadas pelos países que almejam o desenvolvimento sustentável nas mais diversas áreas a luz da Agenda 21 de cada país são alguns dos temas que dão sustento a este trabalho podendo entender as vantagens e desvantagens na escolha de um crescimento baseado na sustentabilidade. Portanto, o presente estudo pretende fazer uma breve análise de como estão sendo incorporadas as políticas públicas para o desenvolvimento sustentável em Cabo Verde com o intuito de andar alinhado com todos os objetivos estabelecidos pela Organização das Nações Unidas (ONU) ao longo das suas conferências

Espacialização e dinâmica da cafeicultura mineira entre 1990 e 2008, utilizando técnicas de geoprocessamento

The aim of this study was to identify coffee cropped areas and production spatial patterns in the state of MinasGerais between 1990 and 2009. IBGE and Statistic Coffee Yearbook data were used. The data was treated by the TerraViewGeographic Information System, which overlaid the coffee information with the state’s district cartographic division. During theyears studied, the cultivated area increased by 17.13%. The South/Southwest, Zona da Mata and Northern regions presentedthe highest growth. The regions Central Mineira and Vale do Mucuri had their coffee areas reduced. The production of the Zonada Mata and South/Southwest regions of the state increased. There was also a reduction of 20.46% in the number of districtsthat produce up to 50,000 60 kg bags of coffee per year. A comparison of the IBGE and Statistic Coffee Yearbook data evidenceda large discrepancy between the official statistics, which showed a greater alignment only from the year 2002 onwards.Objetivou-se, neste trabalho, avaliar e detectar padrões espaciais de área plantada e produção cafeeira no estado deMinas Gerais, entre os anos de 1990 e 2008. Para tanto, foram utilizados dados do IBGE, e o sistema de informação geográficaTerraView, que permitiu a agregação das informações cadastrais do IBGE com a divisão municipal cartográfica do Estado. Aintegração dos dados num SIG permitiu visualizar os dados espacialmente, e possibilitou a identificação das regiões do Estadomais importantes para a cafeicultura. Entre os anos de 1990 e 2009, houve um acréscimo de 16,51% na área plantada, sendo queas mesorregiões Sul/Sudoeste de Minas e Zona da Mata foram as que apresentaram maior crescimento da cafeicultura. Por outrolado, as mesorregiões Central Mineira e Vale do Mucuri tiveram suas áreas de café diminuídas nesse mesmo período. Os mapasde densidade de área plantada, em relação à área do município, revelaram que as regiões Sul/Sudoeste de Minas e Zona da Matasão as que mais dependem economicamente da cafeicultura. Com relação à produção, houve uma redução do número demunicípios que produzem menos de 50 mil sacas e um aumento dos que produzem mais de 50 mil sacas. Os dados de produçãodo IBGE foram comparados aos do Anuário Estatístico do Café, observando-se uma enorme diferença de grandezas entre osdados, até o ano 2002