Overcoming the systemic challenges of retrofitting residential buildings in the United Kingdom. A Herculean task?

Policy initiatives in the UK, such as the Green Deal, have sought and failed to achieve the mass uptake of comprehensive residential retrofit. This chapter argues that previous policies have failed to address four interrelated challenges that constrain consumer demand. Thus, we focus on solutions to address these challenges from three key perspectives: business models, finance mechanisms and intermediaries. We first identify the systemic challenges for whole house retrofit and argue that a more comprehensive and wide-reaching policy strategy will be needed to overcome these challenges. This will require consistent and ambitious policy targets, and the creation or support of new finance mechanisms, business models and dedicated intermediary actors to support policy implementation

Guides or gatekeepers? Incumbent-oriented transition intermediaries in a low-carbon era

Transitions intermediaries—agents who connect diverse groups of actors involved in transitions processes and their skills, resources and expectations—are becoming more prominent in research on low-carbon transitions. Most work, however, has focused on their ability to push innovations or emerging technologies forward, emphasising their involvement in disrupting incumbent regimes or firms. However, in focusing on new entrants, often at the grassroots level, such literature runs the risk of overlooking the potentially positive role that incumbent transition intermediaries—those oriented to work with or centrally consider the interests of dominant government, market or civic stakeholders—can play in meeting sustainable energy and transport goals. In this paper, we focus specifically on five different incumbent transition intermediaries—Smart Energy GB in the United Kingdom, Energiesprong in the Netherlands, SULPU in Finland, CERTU in France, and the Norwegian Electric Vehicle Association in Norway—and explain their efforts to meet socially desirable goals of accelerating innovation or decarbonizing energy or transport systems. We ask: Why were these intermediaries created, and what problems do they respond to? How do they function? What are their longer-term visions and strategies? What are their longer-term strategies and aspirations? In what ways do they reflect, reinforce, or otherwise shape incumbency? In answering these questions via a comparative case study approach, the paper aims to make contributions to the study of incumbency intermediation in the context of transitions, to identifying different types of incumbent intermediaries (market, governmental, civic), and to informing debates over energy and climate policy and politics

Extended Debridement and Skin Graft as Local Treatment of Cobra Snake Bite Injury: A Case Report

Snakebite is a serious issue in rural areas of developing countries as Uganda. In children above all snakebite seems to be more common. Availability of anti-venoms is very poor. Local tissue damage caused by snake venom, either cytotoxic or necrotic, can continue even after systemic crisis has expired. We report the case of a 5 years old male child, born in Kitgum district, Northern Uganda, carried in hospital for a Cobra snake bite on the right foot who could not receive anti-venom. Debridement of the bite site, wound lavage, amputation and skin graft were required. Progression of the local infection associated to the reappearance of high fever induced us to bring the debridement up to the leg almost at the level of the knee in order to prevent unset of tibial Osteomyelitis and to be able to perform skin grafting.Keywords: Snakebite, Cobra, surgical treatment, debridement, skin graft, osteomyeliti

LaparostomicTreatment of Diffuse Peritonitis in Northern Uganda

No Abstract. Keywords: Bacterial infection, Diagnosis; Surgery, laparostomy, laparostomic treatment, peritonitis, uterine perforation, second look

The Role of Corpus Callosum Development in Functional Connectivity and Cognitive Processing

The corpus callosum is hypothesized to play a fundamental role in integrating information and mediating complex behaviors. Here, we demonstrate that lack of normal callosal development can lead to deficits in functional connectivity that are related to impairments in specific cognitive domains. We examined resting-state functional connectivity in individuals with agenesis of the corpus callosum (AgCC) and matched controls using magnetoencephalographic imaging (MEG-I) of coherence in the alpha (8–12 Hz), beta (12–30 Hz) and gamma (30–55 Hz) bands. Global connectivity (GC) was defined as synchronization between a region and the rest of the brain. In AgCC individuals, alpha band GC was significantly reduced in the dorsolateral pre-frontal (DLPFC), posterior parietal (PPC) and parieto-occipital cortices (PO). No significant differences in GC were seen in either the beta or gamma bands. We also explored the hypothesis that, in AgCC, this regional reduction in functional connectivity is explained primarily by a specific reduction in interhemispheric connectivity. However, our data suggest that reduced connectivity in these regions is driven by faulty coupling in both inter- and intrahemispheric connectivity. We also assessed whether the degree of connectivity correlated with behavioral performance, focusing on cognitive measures known to be impaired in AgCC individuals. Neuropsychological measures of verbal processing speed were significantly correlated with resting-state functional connectivity of the left medial and superior temporal lobe in AgCC participants. Connectivity of DLPFC correlated strongly with performance on the Tower of London in the AgCC cohort. These findings indicate that the abnormal callosal development produces salient but selective (alpha band only) resting-state functional connectivity disruptions that correlate with cognitive impairment. Understanding the relationship between impoverished functional connectivity and cognition is a key step in identifying the neural mechanisms of language and executive dysfunction in common neurodevelopmental and psychiatric disorders where disruptions of callosal development are consistently identified

Spatial effects on species persistence and implications for biodiversity

Natural ecosystems are characterized by striking diversity of form and functions and yet exhibit deep symmetries emerging across scales of space, time and organizational complexity. Species-area relationships and species-abundance distributions are examples of emerging patterns irrespective of the details of the underlying ecosystem functions. Here we present empirical and theoretical evidence for a new macroecological pattern related to the distributions of local species persistence times, defined as the timespans between local colonizations and extinctions in a given geographic region. Empirical distributions pertaining to two different taxa, breeding birds and herbaceous plants, analyzed in a new framework that accounts for the finiteness of the observational period, exhibit power-law scaling limited by a cut-off determined by the rate of emergence of new species. In spite of the differences between taxa and spatial scales of analysis, the scaling exponents are statistically indistinguishable from each other and significantly different from those predicted by existing models. We theoretically investigate how the scaling features depend on the structure of the spatial interaction network and show that the empirical scaling exponents are reproduced once a two-dimensional isotropic texture is used, regardless of the details of the ecological interactions. The framework developed here also allows to link the cut-off timescale with the spatial scale of analysis, and the persistence-time distribution to the species-area relationship. We conclude that the inherent coherence obtained between spatial and temporal macroecological patterns points at a seemingly general feature of the dynamical evolution of ecosystems.Comment: 5 pages, 5 figures. Supplementary materials avaliable on http://www.pnas.org/content/108/11/434

Hill Runner's Physiology, Performance and Nutrition: A Descriptive Study

Objectives: The aim of this descriptive study was to characterise anthropometric variables, aerobic capacity, running performance and energy intake and expenditure of hill runners in free-living conditions, and to investigate the relationship between age, anthropometric variables, aerobic capacity and running performance. Methods: Twenty-eight hill runners participated in this study (17 males and 11 females; aged 18–65 years). Body fat percentage estimate, sum of eight skinfolds (triceps, subscapular, biceps, iliac crest, supraspinale, abdominal, front thigh and medial calf) and maximal oxygen capacity (VO2max) were assessed in a laboratory setting. Participants also completed a timed hill run (Dumyat Hill, Scotland, ascent: 420 m, distance: 8 km) while wearing a portable gas analyzer to assess oxygen consumption (VO2). Energy intake and energy expenditure were assessed in free-living conditions over three consecutive days different from the testing days through self-reported food diaries and accelerometers. Results: VO2max assessed in the lab (51.2 ± 7.6 ml·min−1·kg−1) showed a weak negative relationship with age [rs(23) = −0.38, p = 0.08]. Neither body fat percentage (median 12.4; IQR 10.1–17.1) nor the sum of skinfolds (median 81.8; IQR 62.4–97.8 mm) correlated with age [rs(28) = 0.001, p = 0.10 and 26 rs(28) = −0.02, p = 0.94, respectively]. The observed intensity of the hill run was 89 ± 6% of the age predicted maximum heart rate and 87 ± 9% of the VO2max observed in the lab. Hill running performance correlated with VO2max [r(21) = 0.76, p < 0.001], age [rs(26) = −0.44, p = 0.02] and with estimated body fat percentage and sum of skinfolds [rs(26) = −0.66, p < 0.001 and rs(26) = −0.49, p = 0.01, respectively]. Energy intake negatively correlated with age [rs(26) = −0.43, p = 0.03], with the overall energy intake being significantly lower than the total energy expenditure (2273 ± 550 vs. 2879 ± 510 kcal·day−1; p < 0.001; d = 1.05). Conclusion: This study demonstrated that hill running performance is positively associated with greater aerobic capacity and negatively associated with increases in adiposity and age. Further, the study highlights that hill runners are at risk of negative energy balance