Does morbid obesity influence perioperative outcomes after video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer? Analysis of the Italian VATS group registry

Objectives Obesity in Europe, and worldwide, has been an increasing epidemic during the past decades. Moreover, obesity has important implications regarding technical issues and the risks associated with surgical interventions. Nevertheless, there is a lack of evidence assessing the influence of obesity on video-assisted thoracic surgery (VATS) lobectomy results. Our study aimed to assess the impact of morbid obesity on perioperative clinical and oncological outcomes after VATS lobectomy using a prospectively maintained nationwide registry. Methods The Italian VATS lobectomy Registry was used to collect all consecutive cases from 55 Institutions. Explored outcome parameters were conversion to thoracotomy rates, complication rates, intra-operative blood loss, surgical time, hospital postoperative length of stay, chest tube duration, number of harvested lymph-node, and surgical margin positivity. Results From 2016 to 2019, a total of 4412 patients were collected. 74 patients present morbid obesity (1.7%). Multivariable-adjusted analysis showed that morbid obesity was associated with a higher rate of complications (32.8% vs 20.3%), but it was not associated with a higher rate of conversion, and surgical margin positivity rates. Moreover, morbid obesity patients benefit from an equivalent surgical time, lymph-node retrieval, intraoperative blood loss, hospital postoperative length of stay, and chest tube duration than non-morbid obese patients. The most frequent postoperative complications in morbidly obese patients were pulmonary-related (35%). Conclusion Our results showed that VATS lobectomy could be safely and satisfactorily conducted even in morbidly obese patients, without an increase in conversion rate, blood loss, surgical time, hospital postoperative length of stay, and chest tube duration. Moreover, short-term oncological outcomes were preserved

Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?

Recent efforts to improve survival in patients with locally advanced esophageal carcinoma have combined both systemic and local therapy. However, the role of neoadjuvant chemoradiotherapy in technically operable IIa-III esophageal carcinoma is still unresolved

Posterior mediastinal melanoma causing severe dysphagia: A case report

<p>Abstract</p> <p>Introduction</p> <p>We describe an original case of progressive severe dysphagia caused by a posterior mediastinal metastatic melanoma of unknown origin. To the best of our knowledge, such an event has never been described before in the literature.</p> <p>Case presentation</p> <p>A progressive severe dysphagia case is reported induced by a melanoma of unknown origin (metastatic to a posterior mediastinal lymph node). At the time of diagnosis, the lesion appeared as a large posterior mediastinal mass mimicking a neurogenic tumour with oesophageal involvement. After complete resection, pathological assessment of the tumour by immunohistochemistry was consistent with nodal metastatic melanoma.</p> <p>Conclusion</p> <p>This report of a posterior mediastinal lymph node melanoma is unique. The nodal origin is definitely unusual: a primary melanoma should always be carefully ruled out. In fact no other evidence, a part from the absence of the tumour elsewhere, can support the diagnosis of a primary nodal melanoma.</p

High incidence of vascular complication after computed tomography guided lung biopsy : what's matter , the patient or the tecnique?

We read with interest the article of Anzidei on a predicitive score of complication after lung computed tomography -guided biopsy . We think there is a percentage of complications especially pneumotohorax which are impossible to avoid , but it would be useful to predict in which cases they occur with hiogh frequency

Is Post-Operative Lung Ultrasonography Effective in Lung Abnormalities Analysis?

We read with interest the article of Dr. Patella (1) about the use of chest ultrasonography after thoracic surgery for pneumothorax evaluation and management. We completely agree about the use of ultrasound in the post-operative evaluation with the possibility to reduce the number of chest X-ray (CXR). In fact, it is well known that in many cases the postoperative CXR, especially when daily performed, represents a possible waste of time and resources(2)

Surgical Effectiveness of Uniportal-VATS Lobectomy Compared to Open Surgery in Early-Stage Lung Cancer

BackgroundAlthough the feasibility and safety of Uniportal-Video-Assisted thoracic surgery (U-VATS) has been proven, its surgical effectiveness is still debated. The aim of this study is to assess the equivalence of the U-VATS approach compared with an open technique in terms of surgical (nodal-upstaging, complications, and post-operative results) and short-term survival outcomes. MethodsThe clinical data of patients undergoing lobectomy for NSCLC at our center, from January 2014 to December 2019, were analyzed retrospectively. All patients undergoing open or U-VATS lobectomy with lymphadenectomy for early-stage lung cancer (cT1-T3N0, stages IA-IIB) were included in the study. Only 230 patients satisfied the inclusion criteria. Group bias was reduced through 1:1 propensity score matching, which resulted in 46 patients in each group (open surgery and U-VATS). ResultsThe intra- and post-operative mortality were null in both groups. There was no difference in the post-operative complications (p: 1.00) between U-VATS and open lobectomy. There was also no recorded difference in the pathological nodal up-staging [11 (23.9%) after thoracotomy vs. 8 (17.4%) after U-VATS, p: 0.440). The chest tube duration was longer in the open group (p: 0.025), with a higher post-operative pain (p: 0.001). Additionally, the 3-year overall survival (OS) was 78% after U-VATS lobectomy vs. 74% after open lobectomy (p: 0.204), while 3-year disease-specific survival (DSS) was 97 vs. 89% (p: 0.371), respectively. The 3-year disease-free survival (DFS) was 62% in the U-VATS group and 66% in the thoracotomy group, respectively (p: 0.917). ConclusionsUniportal-VATS lobectomy for the treatment of early-stage lung cancer seems to be a safe and effective technique with similar surgical and short-term survival outcomes as open surgery, but with lower post-operative pain and shorter in-hospital stay

Correction to: Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study

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An overview of Alpine and Mediterranean palaeogeography, terrestrial ecosystems and climate history during MIS 3 with focus on the Middle to Upper Palaeolithic transition

This paper summarizes the current state of knowledge about the millennial scale climate variability characterizing Marine Isotope Stage 3 (MIS 3) in S-Europe and the Mediterranean area and its effects on terrestrial ecosystems. The sequence of Dansgaard-Oeschger events, as recorded by Greenland ice cores and recognizable in isotope profiles from speleothems and high-resolution palaeoecological records, led to dramatic variations in glacier extent and sea level configuration with major impacts on the physiography and vegetation patterns, both latitudinally and altitudinally. The recurrent succession of (open) woodlands, including temperate taxa, and grasslands with xerophytic elements, have been tentatively correlated to GIs in Greenland ice cores. Concerning colder phases, the Greenland Stadials (GSs) related to Heinrich events (HEs) appear to have a more pronounced effect than other GSs on woodland withdrawal and xerophytes expansion. Notably, GS 9-HE4 phase corresponds to the most severe reduction of tree cover in a number of Mediterranean records. On a long-term scale, a reduction/opening of forests throughout MIS 3 started from Greenland Interstadials (GIs) 14/13 (ca. 55\u201348 ka), which show a maximum in woodland density. At that time, natural environments were favourable for Anatomically Modern Humans (AMHs) to migrate from Africa into Europe as documented by industries associated with modern hominin remains in the Levant. Afterwards, a variety of early Upper Palaeolithic cultures emerged (e.g., Uluzzian and Proto-Aurignacian). In this chronostratigraphic framework, attention is paid to the Campanian Ignimbrite tephra marker, as a pivotal tool for deciphering and correlating several temporal-spatial issues crucial for understanding the interaction between AMHs and Neandertals at the time of the Middle to Upper Palaeolithic transition