Fatores de risco relacionados à ocorrência da síndrome de burnout em profissionais de saúde que atuam em maternidades públicas durante a pandemia do Coronavírus

The challenges of the current pandemic imposed on health professionals the adequacy of the work process, including in maternity hospitals, which was often in direct contradiction with the evidence of humanization of care. This can result in increasing levels of occupational damage. In this sense, the study aimed to analyze the factors associated with burnout syndrome (BS) among health professionals who work in the care of pregnant women, postpartum women and newborns in public maternity hospitals in Aracaju during the coronavirus pandemic. This is a descriptive study with a quantitative approach, carried out with health professionals who worked in maternal and child care in maternity hospitals. The sample was carried out for convenience and had the participation of 218 professionals, the findings revealed that 98.2% of professionals had positive symptoms in at least one of the three dimensions evaluated, which suggested the diagnosis of BS. The pandemic had a strong impact on the emotional health of the teams of the maternity hospitals studied, which resulted in a high occurrence of BS. Based on the presence of factors that predisposed to the emergence of the syndrome, an implementation of actions that seek to take care of the work environment of these professionals can be suggested.Introdução: os desafios da atual pandemia impuseram aos profissionais de saúde a adequação do processo de trabalho, inclusive nas maternidades, que muitas vezes estava em contradição direta com as evidências de humanização da assistência. Isso pode resultar em níveis crescentes de danos ocupacionais. Objetivo: analisar os fatores associados à Síndrome de Burnout (SB) entre profissionais de saúde que atuam na assistência às gestantes, puérperas e recém-nascidos nas maternidades públicas de Aracaju durante a pandemia do coronavírus. Metodologia: trata-se de um estudo descritivo com abordagem quantitativa, realizado com profissionais de saúde que atuavam na assistência materno-infantil nas maternidades. Resultados: A amostra foi realizada por conveniência e contou com a participação de 218 profissionais, os achados revelaram que 98,2% dos profissionais apresentaram sintomatologia positiva ao menos em uma das três dimensões avaliadas, que sugeriram o diagnóstico da SB. Conclusão: a pandemia trouxe forte impacto à saúde emocional às equipes das maternidades estudadas o que resultou em uma alta ocorrência da SB. Com base na presença dos fatores que predispuseram ao surgimento da síndrome pode ser sugerido uma implementação de ações que busquem cuidar do ambiente de trabalho desses profissionais

Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats

Background: Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals’ lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats. Methodology: Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT). Animals in the trained groups were submitted to an incomplete SCI at T9. Thereafter, they performed a protocol of resistance training for four weeks. Results: Significant differences in muscle damage markers and oxidative stress in the trained groups, mainly in SCI- AT, were found. On the other hand, SCI- U group presented higher levels of oxidative stress and biomarkers of LDH and AST. Conclusion: The results highlight that resistance training promoted a decrease in oxidative stress and a significative response in muscle damage markers. Keywords: spinal cord injury; resistance training; oxidative stress; muscle damag

Quality of life in individuals with tinnitus with and without hearing loss

ABSTRACT Purpose: to evaluate the perception of the level of quality of life in subjects with tinnitus, with and without hearing loss. Methods: a cross-sectional quantitative study. A total of 189 subjects (mean age 53.06 years) divided into four groups. Group 1: subjects with normal auditory thresholds without tinnitus complaint; Group 2: subjects with normal auditory thresholds and tinnitus complaint; Group 3: subjects with sensorineural hearing loss without tinnitus complaint; Group 4: subjects with sensorineural hearing loss and with tinnitus complaint. Levels of quality of life were investigated through the World Health Organization Quality Of Life (WHOQOL) website - brief and psycho-emotional and functional aspects of patients with tinnitus through the Tinnitus Handicap Inventory (THI). Statistical analyzes, comparisons among groups and descriptive analysis were performed, considering a significance level of 5%. Results: the overall mean scores of quality of life in group 4 (56.07) were smaller than those of group 1 (64.67) (p<0.05). The subjects with tinnitus complaint presented a moderate level of disturbance of the symptom. Conclusion: tinnitus interferes in the quality of life of individuals who had preserved or altered auditory thresholds. Therefore, means to reduce the discomfort caused by tinnitus symptom should be developed, in order to improve patients' quality of life

Quality of life in individuals with tinnitus with and without hearing loss

<div><p>ABSTRACT Purpose: to evaluate the perception of the level of quality of life in subjects with tinnitus, with and without hearing loss. Methods: a cross-sectional quantitative study. A total of 189 subjects (mean age 53.06 years) divided into four groups. Group 1: subjects with normal auditory thresholds without tinnitus complaint; Group 2: subjects with normal auditory thresholds and tinnitus complaint; Group 3: subjects with sensorineural hearing loss without tinnitus complaint; Group 4: subjects with sensorineural hearing loss and with tinnitus complaint. Levels of quality of life were investigated through the World Health Organization Quality Of Life (WHOQOL) website - brief and psycho-emotional and functional aspects of patients with tinnitus through the Tinnitus Handicap Inventory (THI). Statistical analyzes, comparisons among groups and descriptive analysis were performed, considering a significance level of 5%. Results: the overall mean scores of quality of life in group 4 (56.07) were smaller than those of group 1 (64.67) (p<0.05). The subjects with tinnitus complaint presented a moderate level of disturbance of the symptom. Conclusion: tinnitus interferes in the quality of life of individuals who had preserved or altered auditory thresholds. Therefore, means to reduce the discomfort caused by tinnitus symptom should be developed, in order to improve patients' quality of life.</p></div

Estudo da ação antibacteriana do extrato hidroalcoólico de própolis vermelha sobre Enterococcus faecalis

Introdução: A própolis é uma substância resinosa e complexa; produzida pelas abelhas, destaca-se por suas propriedades terapêuticas, como atividade antimicrobiana, anti-inflamatória e cicatrizante. Poucos trabalhos existem sobre a variedade de própolis vermelha, encontrada no Estado de Sergipe. Objetivo: Avaliar a ação antimicrobiana do extrato de própolis vermelha, coletada na região nordeste do Estado de Sergipe, contra cepas de Enterococcus faecalis. Material e método: As amostras de própolis vermelha foram coletadas em Brejo Grande-SE, Brasil, e identificadas segundo suas características sensoriais, a granulometria e requisitos físico-químicos. O teor de flavonoides no extrato seco foi determinado. Soluções de própolis vermelha (EEP) foram preparadas nas concentrações de 1%; 2,5%; 5% e 7,5%. A cepa bacteriana de referência utilizada foi Enterococcus faecalis – ATCC 29212. A atividade antibacteriana foi verificada por meio de testes in vitro (teste de difusão em disco e determinação da concentração bactericida mínima – CBM) e ex vivo (utilizando dentes humanos extraídos). No teste ex vivo, os dentes contaminados foram divididos em três grupos com dez dentes cada. O grupo 1 foi tratado com própolis a 7,5% (concentração determinada no teste CBM); o grupo 2 foi tratado como controle positivo, com solução de hipoclorito de sódio a 2,5%, e o grupo 3 foi utilizado como controle negativo, sendo tratado apenas com solução salina NaCl 0,9%. Resultado: O extrato de própolis promoveu halo de inibição comparado ao da solução de hipoclorito de sódio a 2,5%, variando entre 12 e 16 mm. Não houve crescimento bacteriano após irrigação do conduto radicular com a solução de EEP a 7,5%. Conclusão: A própolis coletada apresentou médio teor de flavonoides (1,8%) e características físico-químicas coerentes com as exigidas pelo Ministério da Agricultura. Na concentração de 7,5% de própolis vermelha, foi observado um maior potencial antibacteriano quando comparado aos demais grupos

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats Efeito proliferativo do extrato aquoso da Hyptis fructicosa na regeneração hepática após hepatectomia parcial em ratos

PURPOSE: To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS: Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS: The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION: These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.<br>OBJETIVO: Avaliar o efeito do extrato aquoso da Hyptis fructicosa sobre a regeneração hepática após hepatectomia parcial em ratos. MÉTODOS: Dezesseis ratos foram divididos em dois grupos: C (grupo controle) e HF (ratos que receberam o extrato aquoso da Hyptis fructicosa durante quatro dias na dose de 100mg/kg/dia). No dia consecutivo deste tratamento, os animais de ambos os grupos foram submetidos a hepatectomia de aproximadamente 67% do fígado. Vinte e quatro horas depois, eles foram sacrificados, e que a massa restante do fígado foi retirado e preparado para ser estudado através da técnica de imuno-histoquímica PCNA. RESULTADOS: O índice de regeneração hepática do grupo HF foi 53,56 ± 18,91%, enquanto no grupo C foi de 21,12 ± 8,29% (p=0,0003). CONCLUSÃO: Estes resultados mostram que a administração do extrato aquoso da Hyptis fructicosa na dose de 100mg/kg/dia aumentou a proliferação de hepatócitos no grupo HF

Modulation of dopamine uptake by nitric oxide in cultured mesencephalic neurons

Strong evidence obtained from in vivo and ex-vivo studies suggests the existence of interaction between dopaminergic and nitrergic systems. Some of the observations suggest a possible implication of nitric oxide (NO) in dopamine (DA) uptake mechanism. The present work investigated the interaction between both systems by examining the effect of an NO donor, sodium nitroprusside (SNP), associated with the indirect DA agonist, amphetamine (AMPH) on tritiated DA uptake in cultures of embryonic mesencephalic neurons. Consistent with the literature, both AMPH (1, 3 and 10 mu M) and SNP (300 mu M and 1 mM) inhibited DA uptake in a dose-dependent manner. In addition, the inhibition of DA uptake by AMPH (1 and 3 mu M) was significantly increased by the previous addition of SNP (300 mu M). The implication of NO in this interaction was supported by the fact that the free radical scavenger N-acetyl-L-Cysteine (500 mu M) significantly increased DA uptake and completely abolished the effect of SNP, leaving unaffected that from AMPH on DA uptake. Further, double-labeling immunohistochemistry showed the presence of tyrosine hydroxylase-(TH, marker for dopaminergic neurons) and neuronal NO synthase- (nNOS, marker for NO containing neurons) expressing neurons in mesencephalic cultures. Some dopaminergic neurons also express nNOS giving further support for a pre-synaptic interaction between both systems. This is the first work demonstrating in mesencephalic cultured neurons a combined effect of an NO donor and an indirect DA agonist on specific DA uptake. (C) 2008 Elsevier B.V. All rights reserved