Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase complex

Higher eukaryotes have developed extensive compartmentalization of amino acid (aa) - tRNA coupling through the formation of a multi-synthetase complex (MSC) that is composed of eight aa-tRNA synthetases (ARS) and three scaffold proteins: aminoacyl tRNA synthetase complex interacting multifunctional proteins (AIMP1, 2 and 3). Lower eukaryotes have a much smaller complex while yeast MSC consists of only two ARS (MetRS and GluRS) and one ARS cofactor 1 protein, Arc1p (Simos et al., 1996), the homolog of the mammalian AIMP1. Arc1p is reported to form a tripartite complex with GluRS and MetRS through association of the N-terminus GST-like domains (GST-L) of the three proteins (Koehler et al., 2013). Mammalian AIMP1 has no GST-L domain corresponding to Arc1p N-terminus. Instead, AIMP3, another scaffold protein of 18 kDa composed entirely of a GST-L domain, interacts with Methionyl-tRNA synthetase (MARS) (Quevillon et al., 1999) and Glutamyl-Prolyl-tRNA Synthetase (EPRS) (Cho et al., 2015). Here we report two new interactions between MSC members: AIMP1 binds to EPRS and AIMP1 binds to AIMP3. Interestingly, the interaction between AIMP1 and AIMP3 complex makes it the functional equivalent of a single Arc1p polypeptide in yeast. This interaction is not mapped to AIMP1 N-terminal coiled-coil domain, but rather requires an intact tertiary structure of the entire protein. Since AIMP1 also interacts with AIMP2, all three proteins appear to compose a core docking structure for the eight ARS in the MSC complex

Falling Through the Net? Gender and Social Protection in the Pacific

This paper examines the gender dimensions and implications of social protection in relation to rapid transformations in the globalizing economies in the Pacific region. The paper analyzes the dynamics of gender and social protection in three countries of the region -- Papua New Guinea, Tonga and Vanuatu -- and explores how best to approach social protection so as to promote gender equality rather than risk reinscribing prevailing gender inequalities. The paper emphasizes the need to move beyond bipolar divisions of customary and commodity economies or informal and formal economies to consider the everyday realities of making a living. Women will 'fall through the net' if social protection is unduly yoked to the public sphere of the state and the formal commodity economy in which women are marginalised. Women's own perceptions of their contemporary situation and their agency as both individuals and collectivities should be carefully heeded in finding creative solutions for gender equality in social protection for sustainable Pacific futures. The paper concludes by suggestion that efforts to ensure women's social protection in the Pacific need to be alert to the risks that women might 'fall through the net.' This paper was produced for UN Women's flagship report Progress of the World's Women 2015-2016 to be released as part of the UN Women discussion paper series

Dialogismo : lenguas extranjeras e identidad cultural

1 archivo PDF (6 páginas); incluye ilustraciones en blanco y negro. fhquattuorSe examina y cuestiona el discurso curricular que se ha desarrollado alrededor de la enseñanza de lenguas extranjeras a nivel universitario en México, apoyándose principalmente en las contribuciones de Mijail Bajtín en los campos de la lingüística, la teoría literaria, la filosofía y los estudios culturales

A Study of Supplementary Reading of Entering Freshmen at Prairie View College for 1933 and 1934

To discover the reading interest of students as to the number of books read, the types of books preferred and to get an idea about the quality and quantity of books they were exposed to

In Their Words: A Phenomenological Study of the Experience of the Mentees in the Citizen Scholars Program

This phenomenological study examined the mentoring experience of five students involved in a community-based mentoring program developed to guide high ability, low-socioeconomic students from sixth grade through high-school graduation and on to college acceptance and graduation. This study explored, from student perspectives, how each student experienced and interpreted their personal mentoring relationship. Additionally, it explored each student’s perception of how the mentoring experience influenced his or her academic achievement and academic self-efficacy. The study followed an interpretative phenomenological analysis approach and was guided by Rhodes’s mentoring model and Bandura’s work with self-efficacy. Following the analysis protocol developed by Jonathan Smith, semi-structured, in-depth interviews were used as the data source. The researcher conducted several readings of the interview transcripts in order to identify emerging themes. Connected themes were organized into higher-level superordinate themes. A complete analysis was conducted for each interview transcript before moving to the next transcript. After all transcripts were analyzed with themes and superordinate themes having been identified, the researcher looked for connections and patterns between the transcripts as a whole. The quality of mentoring relationship emerged as the most significant superordinate theme, as it influenced the other superordinate themes of mentee social-emotional, cognitive, identity, and self-efficacy development. The superordinate theme of external moderating influences included the mentoring program, the individual mentee’s dispositions, and the mentees’ parents shaped the atmosphere that either facilitated or hindered the mentoring relationship. Few studies have examined the mentoring experience from the mentee’s perspective, particularly as it influences self-efficacy and academic outcomes. As such, this study addressed the gap in the literature as it relates to student perspectives of mentoring outcomes

Africa's world trade

Are Africa's world markets really contributing to development across the continent for individuals, nations and regions? This is the key question posed by Margaret Lee in this provocative book, in which she argues that all too often the voices of African traders are obscured amid a blizzard of statistical analysis. However, it is these very voices - from those operating on the ground as formal or informal traders - that must be listened to in order to form a true understanding of the impact trade regimes have on these individuals and their communities. Featuring a wealth of oral histories from across sub-Saharan Africa and beyond, including Africans in China, Africa's World Trade offers a unique insight into how the complexity of international trade agreements can shape the everyday lives of ordinary Africans

The Crixas Gold Deposit, Brazil: Metamorphism, Metasomatism And Gold Mineralization

The Crixas Gold Deposit is located in Crixas Greenstone Belt, Goias. The area is underlain by metamorphosed Archean rocks consisting of a basal unit of ultramafic rocks. This is overlain by tholeiitic metabasalts which are in turn overlain by meta-pelitic rocks.;Structural hanging wall to footwall lithologic sequence of the deposit consists of: Foliated Amphibolite transitional to Ferroan Dolomite-Chlorite-Biotite-Quartz Schist (FDCBQS), veined Ferroan Dolomite-Chlorite-Sericite-Biotite-Quartz Schist (vFDCSBQS) and Massive Ferroan Dolomite (MFD). These rocks envelope Sericite-Chlorite Schist (SCS) and Chlorite-Magnetite Schist (CMS). Silicified Dolomite and Graphitic Pelite occur below these units. Banded Chlorite-Sericite-Garnet Schist (BCSGS) is in sharp upper contact to Graphitic Pelite and sharp lower contact to Banded Quartz-Biotite-Chlorite-Plagioclase Schist.;Gold occurs associated with arsenopyrite and pyrrhotite within an Upper Ore Zone of FDCBQS, vFDCSBQS, MFD, SCS and CMS and a Lower Ore Zone of Quartz Cemented Graphitic Pelite Breccia (QCGPB) located at or near the contact of Graphitic Pelite and BCSGS.;The Upper and Lower Ore Zones are interpreted as metasomatised parent lithologies. Metasomatism post-dates a maximum regional metamorphism of Epidote-Amphibolite Facies and consists of carbonatization, sericitization, Fe-metasomatism and sulphidization. The Foliated Amphibolite is the carbonatized parent to FDCBS, vFDCSBQS and MFD and sericitized, Fe-metasomatised and sulphidized parent to SCS and CMS. The Graphitic Pelite is the sericitized and sulphidized parent to QCGPB.;Gold deposition resulted from reduced f{dollar}\sb{lcub}\rm S2{rcub}{dollar} due to the sulphidation reaction of S and Fe-silicate minerals to form sulphides. f{dollar}\sb{lcub}\rm O2{rcub}{dollar} is constrained by the presence of graphite and magnetite.;Geothermometric calculations of coexisting garnet and biotite, garnet inclusion textures indicate that the QCGPB represents a major structural and geothermal discontinuity. It is proposed that shearing related low angle thrusting accounts for the development of both the Lower and Upper Ore Zones. The age of this thrusting is not known, but is speculated to be Brasiliano Cycle in age (570 Ma)

Construction of a test to evaluate certain composition skills at the intermediate grade level

Thesis (M.A.)--Boston University, 1947. This item was digitized by the Internet Archive

The institutionalisation of charism in a faith-based school

The research problem underpinning this study concerns the congruence between Dominican charism and how it is experienced by students, teachers and parents at San Sisto College. The purpose of the research is to explore how students, teachers and parents experience Dominican charism. Three specific research questions focus the conduct of this study: What do students, teachers and parents understand Dominican charism to be? How do students, teachers and parents experience Dominican charism at San Sisto College? How is Dominican charism nurtured at San Sisto College