The locality of the fourth root of staggered fermion determinant in the interacting case

The fourth root approximation in LQCD simulations with dynamical staggered fermions requires justification. We test its validity numerically in the interacting theory in a renormalization group framework.Comment: 6 pages, Talk presented at Lattice 2005 (Machines and Algorithms

The Equation of State for QCD with 2+1 Flavors of Quarks

We report results for the interaction measure, pressure and energy density for nonzero temperature QCD with 2+1 flavors of improved staggered quarks. In our simulations we use a Symanzik improved gauge action and the Asqtad $O(a^2)$ improved staggered quark action for lattices with temporal extent $N_t=4$ and 6. The heavy quark mass $m_s$ is fixed at approximately the physical strange quark mass and the two degenerate light quarks have masses $m_{ud} =0.1m_s$ or $0.2m_s$. The calculation of the thermodynamic observables employs the integral method where energy density and pressure are obtained by integration over the interaction measure.Comment: 6 pages, 1 figure, 3 tables, contribution to the XXIIIrd International Symposium on Lattice Field Theory, 25-30 July 2005, Trinity College, Dublin, Irelan

Update on pi and K Physics

We present an update of the MILC studies of the physics of light pseudoscalars using improved staggered fermions. New runs at lighter quark mass, as well as increased statistics for older sets, are enabling us to improve the results for decay constants in full QCD. In addition, we have analyzed quenched runs at two different lattice spacings. This makes possible a test of the applicability of staggered chiral perturbation theory in a different context.Comment: presented at Lattice2005(Hadron Spectrum), Dublin, July 25-30, 2005, 6 pages, 4 figures, to appear in Proceedings of Scienc

More evidence of localization in the low-lying Dirac spectrum

We have extended our computation of the inverse participation ratio of low-lying (asqtad) Dirac eigenvectors in quenched SU(3). The scaling dimension of the confining manifold is clearer and very near 3. We have also computed the 2-point correlator which further characterizes the localization.Comment: presented at Lattice2005(Topology and Confinement), Dublin, July 25-30, 2005, 6 pages, 3 figures, to appear in Proceedings of Scienc

Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Current Biology 19 (2009): 1210-1215, doi:10.1016/j.cub.2009.05.061.During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin. It is generally accepted that this RanGTP gradient is essential for organizing the spindle since it locally activates critical spindle assembly factors. Here, we show in Xenopus egg extract, where the gradient is best characterized, that spindles can assemble in the absence of a RanGTP gradient. Gradient-free spindle assembly occurred around sperm nuclei but not around chromatin-coated beads and required the chromosomal passenger complex (CPC). Artificial enrichment of CPC activity within hybrid bead arrays containing both immobilized chromatin and the CPC supported local microtubule assembly even in the absence of a RanGTP gradient. We conclude that RanGTP and the CPC constitute the two major molecular signals that spatially promote microtubule polymerization around chromatin. Furthermore, we hypothesize that the two signals mainly originate from discreet physical sites on the chromosomes to localize microtubule assembly around chromatin: a RanGTP signal from any chromatin, and a CPC-dependent signal predominantly generated from centromeric chromatin.This work was supported by the American Cancer Society (grant PF0711401 to T.J. Maresca), the National Cancer Institute (grant CA078048-09 to T.J. Mitchison) and the National Institutes of Health (grant F32GM080049 to J.C. Gatlin and grant GM24364 to E.D. Salmon)

Pressure Modulator Radiometer (PMR) tests

The pressure modulator technique was evaluated for monitoring pollutant gases in the Earth's atmosphere of altitude levels corresponding to the mid and lower troposphere. Using an experimental set up and a 110 cm sample cell, pressure modulator output signals resulting from a range of gas concentrations in the sample cell were examined. Then a 20 cm sample cell was modified so that trace gas properties in the atmosphere could be simulated in the laboratory. These gas properties were measured using an infrared sensor

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle

The African clawed frog Xenopus laevis has been instrumental to investigations of both development and cell biology, but the utility of this model organism for genetic and proteomic studies is limited by its long generation time and unsequenced pseudotetraploid genome. Xenopus tropicalis, which is a small, faster-breeding relative of X. laevis, has recently been adopted for research in developmental genetics and functional genomics, and has been chosen for genome sequencing. We show that X. tropicalis egg extracts reconstitute the fundamental cell cycle events of nuclear formation and bipolar spindle assembly around exogenously added sperm nuclei. Interestingly, X. tropicalis spindles were ∼30% shorter than X. laevis spindles, and mixing experiments revealed a dynamic, dose-dependent regulation of spindle size by cytoplasmic factors. Measurements of microtubule dynamics revealed that microtubules polymerized slower in X. tropicalis extracts compared to X. laevis, but that this difference is unlikely to account for differences in spindle size. Thus, in addition to expanding the range of developmental and cell biological experiments, the use of X. tropicalis provides novel insight into the complex mechanisms that govern spindle morphogenesis

Predictions from Lattice QCD

In the past year, we calculated with lattice QCD three quantities that were unknown or poorly known. They are the $q^2$ dependence of the form factor in semileptonic $D\to Kl\nu$ decay, the decay constant of the $D$ meson, and the mass of the $B_c$ meson. In this talk, we summarize these calculations, with emphasis on their (subsequent) confirmation by experiments.Comment: v1: talk given at the International Conference on QCD and Hadronic Physics, Beijing, June 16-20, 2005; v2: poster presented at the XXIIIrd International Symposium on Lattice Field Theory, Dublin, July 25-3

2/3D imaging based on photonics-enabled multi-band MIMO radar system

Photonics-enabled coherent MIMO radars have been numerically investigated to evaluate the benefits of coherence and multi-band operation in 2/3D imaging

Exercise training improves erectile dysfunction (ED) in patients with metabolic syndrome on phosphodiesterase-5 (PDE-5) inhibitors

Introduction. Erectile dysfunction (ED) affects about 50% of males aged 40-70 years old. ED shares with atherosclerotic disease several common risk factors; therefore, it may be considered a surrogate marker of atherosclerosis. Sincephosphodiesterase-5 inhibitors are well known pharmacologic agents capable of significant improvement in ED, we designed this study to evaluate whether exercise training is of added value in patients with ED who are already on PDE-5 inhibitors. Methods. We recruited 20 male patients affected by ED with metabolic syndrome.At baseline, all patients underwent Cardio-Pulmonary Exercise Testing (CPET) and the International Index of Erectile Function (IIEF) test.After the initial evaluation, patients were subdivided into two groups: tadalafil group (group T, n=10), who were maintained only on tadalafil therapy, and a tadalafil/exercise training group (T/E group, n=10)who continued tadalafil but in addition underwent a2-month structured exercise training program. Results. Basal anthropometric characteristics of study population showed no significant differences. Although bothgroups showed at 2 months an improvement of the IIEF score, thiswas more evident in the T/E group (T group: 11.2 vs 14.2, P=0.02; T/E group: 10.8 vs 20.1, P<0.001). There was an improvement of oxygen consumption at peak exercise (VO2peak) only in the T/E group patients (T group: 13.63±2.03 vs 14.24±2.98 mL/kg/min; P=0.521; T/E group: 13.41±2.97 vs 16.58±3.17 mL/kg/min; P=0.006). A significant correlation was found between the changes in VO2peak and the modifications in IIEF score (r=0.575; P=0.001). Conclusion. Exercise training in ED patients treated with PDE-5 inhibitors is of added valuesincefurther improves ED, as evaluated by IIEF score, and increases functional capacity