Evidence for tuning adipocytes ICER levels for obesity care.

Abnormal adipokine production, along with defective uptake and metabolism of glucose within adipocytes, contributes to insulin resistance and altered glucose homeostasis. Recent research has highlighted one of the mechanisms that accounts for impaired production of adiponectin (ADIPOQ) and adipocyte glucose uptake in obesity. In adipocytes of human obese subjects and mice fed with a high fat diet, the level of the inducible cAMP early repressor (ICER) is diminished. Reduction of ICER elevates the cAMP response element binding protein (CREB) activity, which in turn increases the repressor activating transcription factor 3. In fine, the cascade triggers reduction in the ADIPOQ and GLUT4 levels, which ultimately hampers insulin-mediated glucose uptake. The c-Jun N-terminal kinase (JNK) interacting-protein 1, also called islet brain 1 (IB1), is a target of CREB/ICER that promotes JNK-mediated insulin resistance in adipocytes. A rise in IB1 and c-Jun levels accompanies the drop of ICER in white adipose tissues of obese mice when compared with mice fed with a chow diet. Other than the expression of ADIPOQ and glucose transport, decline in ICER expression might impact insulin signaling. Impairment of ICER is a critical issue that will need major consideration in future therapeutic purposes

Confinement and the photon propagator in 3D compact QED: a lattice study in Landau gauge at zero and finite temperature

On the lattice we study the gauge boson propagator of three dimensional compact QED in Landau gauge at zero and non-zero temperature. The non-perturbative effects are taken into account by the generation of a mass, by an anomalous dimension and by the photon wave function renormalization. All these effects can be attributed to the monopoles: they are absent in the propagator of the singularity-free part of the gauge field. We assess carefully the Gribov copy problem for the propagator and the parameters emerging from the fits.Comment: 25 pages, 32 figures, RevTeX 4; version in print in Phys. Rev. D; typos and figures 5c and 7c correcte

The Gluon Propagator without lattice Gribov copies

We study the gluon propagator in quenched lattice QCD using the Laplacian gauge which is free of lattice Gribov copies. We compare our results with those obtained in the Landau gauge on the lattice, as well as with various approximate solutions of the Dyson Schwinger equations. We find a finite value $\sim (445 \rm{MeV})^{-2}$ for the renormalized zero-momentum propagator (taking our renormalization point at 1.943 GeV), and a pole mass $\sim 640 \pm 140$ MeV.Comment: Discussion of the renormalized gluon propagator and of the Laplacian gauge fixing procedure extended. Version to appear in Phys. Rev. D. 15 pages, 8 figure

Photon propagator, monopoles and the thermal phase transition in 3D compact QED

We investigate the gauge boson propagator in three dimensional compact Abelian gauge model in the Landau gauge at finite temperature. The presence of the monopole plasma in the confinement phase leads to appearance of an anomalous dimension in the momentum dependence of the propagator. The anomalous dimension as well as an appropriate ratio of photon wave function renormalization constants with and without monopoles are observed to be order parameters for the deconfinement phase transition. We discuss the relation between our results and the confining properties of the gluon propagator in non--Abelian gauge theories.Comment: 4 pages, 5 EPS figures, RevTeX 4, uses epsfig.sty; repaced to match version accepted for publication in Phys. Rev. Lett. (discussion on fits is extended

Intra-articular administration of lidocaine plus adrenaline in dogs : pharmacokinetic profile and evaluation of toxicity in vivo and in vitro

The aim of this study was to evaluate the safety of intra-articular (IA) lidocaine plus adrenaline for improving peri-operative analgesia in anaesthetised dogs undergoing arthroscopy of the elbow. A solution of lidocaine (L) 1.98% plus adrenaline 1:100.000 was administered via the IA route and its safety evaluated in terms of cardio- neuro- and chondro-toxicity. No bradycardia or hypotension was recorded from induction to the last observational time point. Signs of toxicity of the nervous system could have been masked by the general anaesthesia but lidocaine concentrations detected in the blood were lower than those thought to be capable of producing toxicity. The assessment of in vitro chondrotoxicity showed a dose- and time-dependent effect of lidocaine on the viability of articular cells. Adrenaline appeared to reduce the chondrotoxicity of 1% lidocaine, following an exposure of up to 30 min

Infrared behavior of the gluon propagator in lattice Landau gauge: the three-dimensional case

We evaluate numerically the three-momentum-space gluon propagator in the lattice Landau gauge, for three-dimensional pure-SU(2) lattice gauge theory with periodic boundary conditions. Simulations are done for nine different values of the coupling $\beta$, from $\beta = 0$ (strong coupling) to $\beta = 6.0$ (in the scaling region), and for lattice sizes up to $V = 64^3$. In the limit of large lattice volume we observe, in all cases, a gluon propagator decreasing for momenta smaller than a constant value $p_{dec}$. From our data we estimate $p_{dec} \approx 350$ MeV. The result of a gluon propagator decreasing in the infrared limit has a straightforward interpretation as resulting from the proximity of the so-called first Gribov horizon in the infrared directions.Comment: 14 pages, BI-TP 99/03 preprint, correction in the Acknowledgments section. To appear in Phys.Rev.

The Infrared Behavior of Gluon and Ghost Propagators in Landau Gauge QCD

A solvable systematic truncation scheme for the Dyson-Schwinger equations of Euclidean QCD in Landau gauge is presented. It implements the Slavnov-Taylor identities for the three-gluon and ghost-gluon vertices, whereas irreducible four-gluon couplings as well as the gluon-ghost and ghost-ghost scattering kernels are neglected. The infrared behavior of gluon and ghost propagators is obtained analytically: The gluon propagator vanishes for small spacelike momenta whereas the ghost propagator diverges stronger than a massless particle pole. The numerical solutions are compared with recent lattice data for these propagators. The running coupling of the renormalization scheme approaches a fixed point, $\alpha_c \simeq 9.5$, in the infrared.Comment: 4 pages, 2 figures, Revtex; revised version accepted for publication in Physical Review Letter

Infinite Volume and Continuum Limits of the Landau-Gauge Gluon Propagator

We extend a previous improved action study of the Landau gauge gluon propagator, by using a variety of lattices with spacings from $a = 0.17$ to 0.41 fm, to more fully explore finite volume and discretization effects. We also extend a previously used technique for minimizing lattice artifacts, the appropriate choice of momentum variable or ``kinematic correction'', by considering it more generally as a ``tree-level correction''. We demonstrate that by using tree-level correction, determined by the tree-level behavior of the action being considered, it is possible to obtain scaling behavior over a very wide range of momenta and lattice spacings. This makes it possible to explore the infinite volume and continuum limits of the Landau-gauge gluon propagator.Comment: 24 pages RevTex, 18 figures; Responses to referee comments, minor change

Exploring Topology Conserving Gauge Actions for Lattice QCD

We explore gauge actions for lattice QCD, which are constructed such that the occurrence of small plaquette values is strongly suppressed. By choosing strong bare gauge couplings we arrive at values for the physical lattice spacings of O(0.1 fm). Such gauge actions tend to confine the Monte Carlo history to a single topological sector. This topological stability facilitates the collection of a large set of configurations in a specific sector, which is profitable for numerical studies in the epsilon-regime. The suppression of small plaquette values is also expected to be favourable for simulations with dynamical quarks. We use a local Hybrid Monte Carlo algorithm to simulate such actions, and we present numerical results for the static potential, the physical scale, the topological stability and the kernel condition number of the overlap Dirac operator. In addition we discuss the question of reflection positivity for a class of such gauge actions.Comment: 28 pages, 8 figure

Freezing of the QCD coupling constant and solutions of Schwinger-Dyson equations

We compare phenomenological values of the frozen QCD running coupling constant ($\alpha_s$) with two classes of solutions obtained through nonperturbative Schwinger-Dyson equations. We use these same solutions with frozen coupling constants as well as their respective nonperturbative gluon propagators to compute the QCD prediction for the asymptotic pion form factor. Agreement between theory and experiment on $\alpha_s(0)$ and $F_\pi (Q^2)$ is found only for one of the solutions Schwinger-Dyson equations.Comment: 6 pages, 4 figures, RevTeX, axodra