The influence of feed on the Merino sheep

The influence of feed on two groups of Merino hamels which were given different quantities of lucerne, mealies, oats, and saltbush was studied. The body weights of the sheep were reduced by 15.8 per cent when the feed was reduced. The sheep that were kept on a full ration gained 10.8 per cent on their initial weights. When the sheep were kept on a reduced ration for nine month and then placed on a full ration, their weights gained by 39.1 per cent. Underfeeding reduced the scoured fleece weights by 31.8 per cent. As regards fibre thickness the underfed group produced a considerably finer wool. The initial fibre fineness of 17.9 µ was reduced to 14.3 µ, a reduction of 36 per cent in cross sectional area. The latter fibre thickness was restored to the initial stage by good feeding. An 80's quality wool was reduced to a 150's by starvation and the latter restored to the original quality number by good feeding.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.mn2015mn201

Influence of regular dipping on the Merino sheep and its fleece

1. A Merino sheep dipping experiment is described at the Bathurst Experiment Station in the coastal region, which for the greater part is a tick-infested area. 2. Ninety Merino hamels were used. Half of the plain-bodied, long loose wool type and half the wrinkly short dense woolled type. Each group was divided into three lots of 15. The first lot dipped weekly in arsenite of soda of strength 2 pounds per 100 gallons of water, the second dipped in water, the third not dipped. There were thus thirty animals for each of the treatments. 3. The aim of the experiment was to establish whether the Merino sheep could withstand and adapt itself to dipping at weekly intervals for twelve months and what effect such dipping will have on the fleece. 4. Results show that weekly dipping does not influence the condition of the sheep as reflected in body weight. 5. All sheep dipped in arsenite of soda, survived after a year's treatment, and were always free from ticks and blowfly trouble. 6. Arsenite of soda had no influence on fleece weights, fibre thickness, staple length and fibre contour. 7. As regards colour, handle and appearance the wools dipped in arsenite and in water have deteriorated to some extent. Deterioration is practically of the same degree in the two dipped groups and presumably due to the hardness of the Bathurst water and not to the arsenite of soda dip. 8. As regards monetary value, as given by Messrs. John Smith & Sons, there is as much as 1d. per pound difference between the Noil from the control and that from the dipped lots, and in the Top a difference of 2d. per pound. The latter quotation at the time of estimating (23rd November, 1931), meant a difference of approximately of 1d. per pound in the grease for a 50 per cent yielding wool, or a reduction in value of about 8 per cent. 9. There was no difference in response between the wrinkly bodied short dense woolled sheep and the plain bodied long loose woolled animals.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

From Goya to Afghanistan. An essay on the ratio and ethics of medical war pictures

For centuries pictures of the dead and wounded have been part and parcel of war communications. Often the intentions were clear, ranging from medical instructions to anti-war protests. The public's response could coincide with or diverge from the publisher's intention. Following the invention of photography in the nineteenth century, and the subsequent claim of realism, the veracity of medical war images became more complex. Analysing and understanding such photographs have become an ethical obligation with democratic implications. We performed a multidisciplinary analysis of War Surgery (2008), a book containing harsh, full-colour photographs of mutilated soldiers from the Iraq and Afghanistan wars. Our analysis shows that, within the medical context, this book is a major step forward in medical war communication and documentation. In the military context the book can be conceived as an attempt to put matters right given the enormous sacrifice some individuals have suffered. For the public, the relationship between the 'reality' and 'truth' of such photographs is ambiguous, because only looking at the photographs without reading the medical context is limiting. If the observer is not familiar with medical practice, it is difficult for him to fully assess, signify and acknowledge the value and relevance of this book. We therefore assert the importance of the role of professionals and those in the humanities in particular in educating the public and initiating debate. © 2010 Taylor & Francis

Cancer stem cell biomarkers predictive of radiotherapy response in rectal cancer: A systematic review

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitouri-nary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradica-tion of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients

Influence of protein (human galectin-3) design on aspects of lectin activity

The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge now is to identify the principles of structure–activity relationships that underlie specificity of recognition and the ensuing post-binding processes. Toward this end, we focus on a distinct feature on the side of the lectin, i.e. its architecture to present the carbohydrate recognition domain (CRD). Working with a multifunctional human lectin, i.e. galectin-3, as model, its CRD is used in protein engineering to build variants with different modular assembly. Hereby, it becomes possible to compare activity features of the natural design, i.e. CRD attached to an N-terminal tail, with those of homo- and heterodimers and the tail-free protein. Thermodynamics of binding disaccharides proved full activity of all proteins at very similar affinity. The following glycan array testing revealed maintained preferential contact formation with N-acetyllactosamine oligomers and histo-blood group ABH epitopes irrespective of variant design. The study of carbohydrate-inhibitable binding of the test panel disclosed up to qualitative cell-type-dependent differences in sections of fixed murine epididymis and especially jejunum. By probing topological aspects of binding, the susceptibility to inhibition by a tetravalent glycocluster was markedly different for the wild-type vs the homodimeric variant proteins. The results teach the salient lesson that protein design matters: the type of CRD presentation can have a profound bearing on whether basically suited oligosaccharides, which for example tested positively in an array, will become binding partners in situ. When lectin-glycoconjugate aggregates (lattices) are formed, their structural organization will depend on this parameter. Further testing (ga)lectin variants will thus be instrumental (i) to define the full range of impact of altering protein assembly and (ii) to explain why certain types of design have been favored during the course of evolution, besides opening biomedical perspectives for potential applications of the novel galectin forms

Effective Hamiltonian Constraint from Group Field Theory

Spinfoam models provide a covariant formulation of the dynamics of loop quantum gravity. They are non-perturbatively defined in the group field theory (GFT) framework: the GFT partition function defines the sum of spinfoam transition amplitudes over all possible (discretized) geometries and topologies. The issue remains, however, of explicitly relating the specific form of the group field theory action and the canonical Hamiltonian constraint. Here, we suggest an avenue for addressing this issue. Our strategy is to expand group field theories around non-trivial classical solutions and to interpret the induced quadratic kinematical term as defining a Hamiltonian constraint on the group field and thus on spin network wave functions. We apply our procedure to Boulatov group field theory for 3d Riemannian gravity. Finally, we discuss the relevance of understanding the spectrum of this Hamiltonian operator for the renormalization of group field theories.Comment: 14 page

Dynamic11 c-methionine pet-ct: Prognostic factors for disease progression and survival in patients with suspected glioma recurrence

Purpose: The prognostic evaluation of glioma recurrence patients is important in the therapeutic management. We investigated the prognostic value of11 C-methionine PET-CT (MET-PET) dynamic and semiquantitative parameters in patients with suspected glioma recurrence. Methods: Sixty-seven consecutive patients who underwent MET-PET for suspected glioma recurrence at MR were retrospectively included. Twenty-one patients underwent static MET-PET; 46/67 underwent dynamic MET-PET. In all patients, SUVmax, SUVmean and tumour-to-background ratio (T/B) were calculated. From dynamic acquisition, the shape and slope of time-activity curves, time-to-peak and its SUVmax (SUVmaxTTP ) were extrapolated. The prognostic value of PET parameters on progression-free (PFS) and overall survival (OS) was evaluated using Kaplan–Meier survival estimates and Cox regression. Results: The overall median follow-up was 19 months from MET-PET. Recurrence patients (38/67) had higher SUVmax (p = 0.001), SUVmean (p = 0.002) and T/B (p < 0.001); deceased patients (16/67) showed higher SUVmax (p = 0.03), SUVmean (p = 0.03) and T/B (p = 0.006). All static parameters were associated with PFS (all p < 0.001); T/B was associated with OS (p = 0.031). Regarding kinetic analyses, recurrence (27/46) and deceased (14/46) patients had higher SUVmaxTTP (p = 0.02, p = 0.01, respectively). SUVmaxTTP was the only dynamic parameter associated with PFS (p = 0.02) and OS (p = 0.006). At univariate analysis, SUVmax, SUVmean, T/B and SUVmaxTTP were predictive for PFS (all p < 0.05); SUVmaxTTP was predictive for OS (p = 0.02). At multivariate analysis, SUVmaxTTP remained significant for PFS (p = 0.03). Conclusion: Semiquantitative parameters and SUVmaxTTP were associated with clinical outcomes in patients with suspected glioma recurrence. Dynamic PET-CT acquisition, with static and kinetic parameters, can be a valuable non-invasive prognostic marker, identifying patients with worse prognosis who require personalised therapy

Encoding simplicial quantum geometry in group field theories

We show that a new symmetry requirement on the GFT field, in the context of an extended GFT formalism, involving both Lie algebra and group elements, leads, in 3d, to Feynman amplitudes with a simplicial path integral form based on the Regge action, to a proper relation between the discrete connection and the triad vectors appearing in it, and to a much more satisfactory and transparent encoding of simplicial geometry already at the level of the GFT action.Comment: 15 pages, 2 figures, RevTeX, references adde

The complete 1/N expansion of colored tensor models in arbitrary dimension

In this paper we generalize the results of [1,2] and derive the full 1/N expansion of colored tensor models in arbitrary dimensions. We detail the expansion for the independent identically distributed model and the topological Boulatov Ooguri model