Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines.

The integrated control of animal physiology requires intimate tissue crosstalk, a vital task mediated by circulating humoral factors. As one type of these factors, adipose tissue-derived adipokines have recently garnered attention as important regulators of systemic insulin sensitivity and metabolic homeostasis. However, the realization that skeletal muscle also secretes a variety of biologically and metabolically active polypeptide factors (collectively called myokines) has provided a new conceptual framework to understand the critical role skeletal muscle plays in coordinating whole-body energy balance. Here, we highlight recent progress made in the myokine field and discuss possible roles of myonectin, which we have recently identified as a potential postprandial signal derived from skeletal muscle to integrate metabolic processes in other tissues, such as adipose and liver; one of its roles is to promote fatty acid uptake into cells. Myonectin is also likely an important mediator in inter-tissue crosstalk

Finite element analysis of fluid-filled elastic piping systems

Two finite element procedures are described for predicting the dynamic response of general 3-D fluid-filled elastic piping systems. The first approach, a low frequency procedure, models each straight pipe or elbow as a sequence of beams. The contained fluid is modeled as a separate coincident sequence axial members (rods) which are tied to the pipe in the lateral direction. The model includes the pipe hoop strain correction to the fluid sound speed and the flexibility factor correction to the elbow flexibility. The second modeling approach, an intermediate frequency procedure, follows generally the original Zienkiewicz-Newton scheme for coupled fluid-structure problems except that the velocity potential is used as the fundamental fluid unknown to symmetrize the coefficient matrices. From comparisons of the beam model predictions to both experimental data and the 3-D model, the beam model is validated for frequencies up to about two-thirds of the lowest fluid-filled labor pipe mode. Accurate elbow flexibility factors are seen to be crucial for effective beam modeling of piping systems

The dynamic analysis of submerged structures

Methods are described by which the dynamic interaction of structures with surrounding fluids can be computed by using finite element techniques. In all cases, the fluid is assumed to behave as an acoustic medium and is initially stationary. Such problems are solved either by explicitly modeling the fluid (using pressure or displacement as the basic fluid unknown) or by using decoupling approximations which take account of the fluid effects without actually modeling the fluid

Exact on-event expressions for discrete potential systems

The properties of systems composed of atoms interacting though discrete potentials are dictated by a series of events which occur between pairs of atoms. There are only four basic event types for pairwise discrete potentials and the square-well/shoulder systems studied here exhibit them all. Closed analytical expressions are derived for the on-event kinetic energy distribution functions for an atom, which are distinct from the Maxwell-Boltzmann distribution function. Exact expressions are derived that directly relate the pressure and temperature of equilibrium discrete potential systems to the rates of each type of event. The pressure can be determined from knowledge of only the rate of core and bounce events. The temperature is given by the ratio of the number of bounce events to the number of disassociation/association events. All these expressions are validated with event-driven molecular dynamics simulations and agree with the data within the statistical precision of the simulations

The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes leaf tissue development

Important goals in understanding leaf development are to identify genes involved in pattern specification, and also genes that translate this information into cell types and tissue structure. Loss-of-function mutations at the JAGGED (JAG) locus result in Arabidopsis plants with abnormally shaped lateral organs including serrated leaves, narrow floral organs, and petals that contain fewer but more elongate cells. jag mutations also suppress bract formation in leafy, apetala1 and apetala2 mutant backgrounds. The JAG gene was identified by map-based cloning to be a member of the zinc finger family of plant transcription factors and encodes a protein similar in structure to SUPERMAN with a single C2H2-type zinc finger, a proline-rich motif and a short leucine-rich repressor motif. JAG mRNA is localized to lateral organ primordia throughout the plant but is not found in the shoot apical meristem. Misexpression of JAG results in leaf fusion and the development of ectopic leaf-like outgrowth from both vegetative and floral tissues. Thus, JAG is necessary for proper lateral organ shape and is sufficient to induce the proliferation of lateral organ tissue

Non-overlapping domain decomposition for the Richards equation via superposition operators

Simulations of saturated-unsaturated groundwater flow in heterogeneous soil can be carried out by considering non-overlapping domain decomposition problems for the Richards equation in subdomains with homogeneous soil. By the application of different Kirchhoff transformations in the different subdomains local convex minimization problems can be obtained which are coupled via superposition operators on the interface between the subdomains. The purpose of this article is to provide a rigorous mathematical foundation for this reformulation in a weak sense. In particular, this involves an analysis of the Kirchhoff transformation as a superposition operator on Sobolev and trace spaces

Toward quantum simulations of biological information flow

Recent advances in the spectroscopy of biomolecules have highlighted the possibility of quantum coherence playing an active role in biological energy transport. The revelation that quantum coherence can survive in the hot and wet environment of biology has generated a lively debate across both the physics and biology communities. In particular, it remains unclear to what extent non-trivial quantum effects are utilised in biology and what advantage, if any, they afford. We propose an analogue quantum simulator, based on currently available techniques in ultra-cold atom physics, to study a model of energy and electron transport based on the Holstein Hamiltonian By simulating the salient aspects of a biological system in a tunable laboratory setup, we hope to gain insight into the validity of several theoretical models of biological quantum transport in a variety of relevant parameter regimes.Comment: 8 Pages, 2 Figures, Non-technical contributing article for the Interface Focus Theme Issue `Computability and the Turning centenary'. Interface Focus http://rsfs.royalsocietypublishing.org/content/early/2012/03/22/rsfs.2011.0109.shor

Does the Performance on Principles of Economics Courses Affect the Overall Academic Success of Undergraduate Business Majors?

Using a sample of 1,339 graduates from an accredited business school and the maximum likelihood technique, this paper explores the relationship between overall academic success and performance on the Principles of Economics courses. The estimated model, which also includes some demographic variables, shows that the rank of professors teaching the course, age of students, and the number of credits earned do not influence business majors' overall academic success. However, the grades earned on the Principles of Economics courses, gender, ethnicity, the major in which the student is enrolled, the number of years the student takes to graduate, as well as whether or not the student is completing a minor significantly affect the overall academic success or the final GPA of business majors.

Higgs-regularized three-loop four-gluon amplitude in N=4 SYM: exponentiation and Regge limits

We compute the three-loop contribution to the N=4 supersymmetric Yang-Mills planar four-gluon amplitude using the recently-proposed Higgs IR regulator of Alday, Henn, Plefka, and Schuster. In particular, we test the proposed exponential ansatz for the four-gluon amplitude that is the analog of the BDS ansatz in dimensional regularization. By evaluating our results at a number of kinematic points, and also in several kinematic limits, we establish the validity of this ansatz at the three-loop level. We also examine the Regge limit of the planar four-gluon amplitude using several different IR regulators: dimensional regularization, Higgs regularization, and a cutoff regularization. In the latter two schemes, it is shown that the leading logarithmic (LL) behavior of the amplitudes, and therefore the lowest-order approximation to the gluon Regge trajectory, can be correctly obtained from the ladder approximation of the sum of diagrams. In dimensional regularization, on the other hand, there is no single dominant set of diagrams in the LL approximation. We also compute the NLL and NNLL behavior of the L-loop ladder diagram using Higgs regularization.Comment: 45 pages, 9 figures; v3: major revision (more stringent tests, discussion of order of limits in the Regge regime