Preface to the Sixth Workshop on Natural Language for Artificial Intelligence (NL4AI)

Natural Language Processing (NLP) is an important research topic in Artificial Intelligence (AI), as it is the target of different scientific and industrial interests. Natural Language is at the crossroad of Learning, Knowledge Representation, and Cognitive Modeling. Several recent AI achievements have repeatedly shown their beneficial impact on complex inference tasks, with huge application perspectives in linguistic modeling, processing, and inferences. However, Natural Language Understanding is still a rich research topic, whose cross-fertilization spans a number of independent areas such as Cognitive Computing, Robotics as well as HumanComputer Interaction. For AI, Natural Languages are the research focus of paradigms and applications but, at the same time, they act as cornerstones of automation, autonomy, and learnability for most intelligent phenomena ranging from Vision to Planning and Social Behaviors. A reflection about such diverse and promising interactions is an important target for current AI studies, fully in the core mission of AI*IA. This workshop, supported by the Special Interest Group on NLP of AI*IA1 and by the Italian Association of Computational Linguistics (AILC)2, aims at providing a broad overview of recent activities in the eld of Human Language Technologies (HLT) in Italy. In this context, the organization of NL4AI 2021 [1] provided researchers with the opportunity to share experiences and insights about AI applications focused on NLP in several domains. The 2022 edition of NL4AI is co-located with the 21th International Conference of the Italian Association for Artificial Intelligence (AIxIA 2022), taking place on November 30th in Udine, Italy. The program of the meeting is available on the official workshop website3. We received 17 submissions, 14 of which were accepted after peer-review

Physical constraints on global social-ecological energy system

Energy is the main driver of human Social-Ecological System (SES) dynamics. Collective energy properties of human SES can be described applying the principles of statistical mechanics: (i) energy consumption repartition; (ii) efficiency; (iii) performance, as efficient power, in relation to the least-action principle. International Energy Agency data are analyzed through the lens of such principles. Declining physical efficiency and growth of power losses emerge from our analysis. Losses mainly depend on intermediate system outputs and non-energy final output. Energy performance at Country level also depends on efficient power consumption. Better and worse performing Countries are identified accordingly. Five policy-relevant areas are identified in relation to the physical principles introduced in this paper: Improve efficiency; Decouple economic growth from environmental degradation; Focus on high value added and labor-intensive sectors; Rationalize inefficient fossil fuel subsidies that encourage wasteful consumption; Upgrade the technological capabilities. Coherently with our findings, policies should support the following actions: (1) redefine sectoral energy distribution shares; (2) Improve Country-level performance, if needed; (3) Reduce intermediate outputs and non-energy final output; (4) Reduce resources supply to improve eco-efficiency together with system performance

High-resolution morpho-bathymetry of the Gulf of Naples, Eastern Tyrrhenian Sea

ABSTRACTWe present a high-resolution bathymetric map of the Gulf of Naples (Italy), which is surrounded by the two main volcanic complexes of Mt. Somma-Vesuvius and Phlegrean Fields. The morphology is obtained from swath bathymetric in a Digital Terrain Model with a 5 m grid cell size. Bathymetric data display the main seafloor morphologies with a resolution never obtained before. These morphologies include the Ammontatura and Dohrn Canyons, the Penta Palummo, Nisida, Miseno and Banco della Montagna banks, and the bathymetric features of the submerged sector of the Somma-Vesuvius volcano. Overall, a prevailing volcanic nature characterizes the seafloor morphologies located in the northern sector, while the southern one is dominated by sedimentary features. The Final Map could be useful for the evaluation of the volcano-related hazards in the area

MULTI-Fake-DetectiVE at EVALITA 2023: Overview of the MULTImodal Fake News Detection and VErification Task

This paper introduces the MULTI-Fake-DetectiVE shared task for the EVALITA 2023 campaign. The task was aimed at exploring multimodality within the realm of fake news and intended to address the problem from two perspectives, represented by the two sub-tasks. In sub-task 1, we aimed to evaluate the effectiveness of multimodal fake news detection systems. In sub-task 2, we sought to gain insights into the interplay between text and images, specifically how they mutually influence the interpretation of content in the context of distinguishing between fake and real news. Both perspectives were framed as classification problems. The paper presents an overview of the task. In particular, we detail the key aspects of the task, including the creation of a new dataset for fake news detection in Italian, the evaluation methodology and criteria, the participant systems, and their results. In light of the obtained results, we argue that the problem is still open and propose some future directions

Comparative Analysis of Gene Expression Data Reveals Novel Targets of Senescence-Associated microRNAs

In the last decades, cellular senescence is viewed as a complex mechanism involved in different processes, ranging from tumor suppression to induction of age-related degenerative alterations. Senescence-inducing stimuli are myriad and, recently, we and others have demonstrated the role exerted by microRNAs in the induction and maintenance of senescence, by the identification of a subset of Senescence-Associated microRNAs (SAmiRs) up-regulated during replicative or stress-induced senescence and able to induce a premature senescent phenotype when over-expressed in human primary cells. With the intent to find novel direct targets of two specific SAmiRs, SAmiR-494 and -486-5p, and cellular pathways which they are involved in, we performed a comparative analysis of gene expression profiles available in literature to select genes down-regulated upon replicative senescence of human primary fibroblasts. Among them, we searched for SAmiR’s candidate targets by analyzing with different target prediction algorithms their 3’UTR for the presence of SAmiR-binding sites. The expression profiles of selected candidates have been validated on replicative and stress-induced senescence and the targeting of the 3’UTRs was assessed by luciferase assay. Results allowed us to identify Cell Division Cycle Associated 2 (CDCA2) and Inhibitor of DNA binding/differentiation type 4 (ID4) as novel targets of SAmiR-494 and SAmiR-486-5p, respectively. Furthermore, we demonstrated that the over-expression of CDCA2 in human primary fibroblasts was able to partially counteract etoposide-induced senescence by mitigating the activation of DNA Damage Response

The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients

Introduction: The pathophysiology of the Corona Virus Disease 2019 (COVID-19) is incompletely known. A robust inflammatory response caused by viral replication is a main cause of the acute lung and multiorgan injury observed in critical patients. Inflammasomes are likely players in COVID-19 pathogenesis. The P2X7 receptor (P2X7R), a plasma membrane ATP-gated ion channel, is a main activator of the NLRP3 inflammasome, of the ensuing release of inflammatory cytokines and of cell death by pyroptosis. The P2X7R has been implicated in COVID-19-dependent hyperinflammation and in the associated multiorgan damage. Shed P2X7R (sP2X7R) and shed NLRP3 (sNLRP3) have been detected in plasma and other body fluids, especially during infection and inflammation. Methods: Blood samples from 96 patients with confirmed SARS-CoV-2 infection with various degrees of disease severity were tested at the time of diagnosis at hospital admission. Standard haematological parameters and IL-6, IL-10, IL-1β, sP2X7R and sNLRP3 levels were measured, compared to reference values, statistically validated, and correlated to clinical outcome. Results: Most COVID-19 patients included in this study had lymphopenia, eosinopenia, neutrophilia, increased inflammatory and coagulation indexes, and augmented sNLRP3, IL-6 and IL-10 levels. Blood concentration of sP2X7R was also increased, and significantly positively correlated with lymphopenia, procalcitonin (PCT), IL-10, and alanine transaminase (ALT). Patients with increased sP2X7R levels at diagnosis also showed fever and respiratory symptoms, were more often transferred to Pneumology division, required mechanical ventilation, and had a higher likelihood to die during hospitalization. Conclusion: Blood sP2X7R was elevated in the early phases of COVID-19 and predicted an adverse clinical outcome. It is suggested that sP2X7R might be a useful marker of disease progression

The use and beauty of ultra-high-resolution seismic reflection imaging in Late Quaternary marine volcaniclastic settings, Bay of Naples, Italy

A Nápolyi-öbölben felvett ultra nagy felbontású egycsatornás (IKB-Seistec™) reflexiós szeizmikus szelvények korábbi geológiai és geofizikai vizsgálatok eredményeivel együtt kivételes, eddig soha nem látott felbontású szeizmikus leképezését nyújtják a Flegrei-mezők és a Somma-Vezúv felszín alá süllyedt késő-pleisztocén–holocén rétegtani felépí - tésének. A szeizmikus szelvényeken látott geometria és gravitációs magvevővel nyert üledékek adatainak összevetéséből Campania partközeli kontinentális talapzatán számos olyan üledékes és vulkáni szerkezet, valamint hidrotermális jelenség került leképezésre, melyek a legutolsó glaciális maximum (kb. 18 000 év) óta keletkeztek. A Pozzuoli-öbölben mért Seistec szelvények jól mutatják a beomlott kaldera gyűrűs vetőjét, a kb. 15 ezer éves Nápolyi Sárga Tufa (NYT) lerakódáshoz vezető kitöréskor felújuló boltozatot, és alátámasztják a deformáció későnegyedidőszaki korára és stílusára vonatkozó hipotéziseket. A szeizmikus szelvényeken látható a NYT rétegeinek töréses szerkezete, valamint hidrotermális fluidum-feláramlások és vulkáni/szubvulkáni intrúziók a gyűrűs vetők mentén. A Somma-Vezúv rétegvulkán előterében a kontinentális talapzat felett mért szeizmikus szelvények leképezték a Vezúv i.sz. 79-es kitörésekor Herculaneum városát elpusztító piroklaszt-ár tengervízbe érésekor keletkező, gravitációsan összeomló homokhullámok szerkezetét is. A Somma-Vezúv és a Pozzuoli-öböl közti, buckás felszínű Banco della Montagna területén mért szelvények és fúrómagok vulkanoklasztos diapírok sorát tárták fel. Ezeket a konszolidálatlan horzsakőből álló testeket a fluidum - feláramlás és aktív kigázosodás hatására kialakult mélybeli túlnyomás hozta fel a tengerfenékre.Very high-resolution, single channel (IKB-Seistec™) reflection seizmic profiles acquired in the Bay of Naples, com - plemented with geological and geophysical data from the literature, provide unprecedented, superb seismic imaging of the latest Pleistocene–Holocene stratigraphic architecture of the submerged sectors Campi Flegrei and Somma-Vesuvius volcanic districts. Seismic profiles were calibrated by gravity core data and document a range of depositional systems, volcanic structures and hydrothermal features that evolved after the onset of the Last Glacial Maximum (~ 18 ka BP) over the continental shelf on the Campania coastal zone. Seistec profiles from the Pozzuoli Bay yield high-resolution images of the shallow structure of the collapse caldera-ring fault — resurgent dome system associated with the eruption of the Neapolitan Yellow Tuff (NYT) (ca 15 ka) and support a working hypothesis to assess the timing and the styles of deformation of the NYT resurgent structure throughout the latest Quaternary. Seismic images also revealed the nature of the fragile deformation of strata along the NYT ring fault system and the occurrence of hydrothermal fluids and volcanic/subvolcanic intrusions ascending along the ring fault zone. Seismic data acquired over the continental shelf off the Somma-Vesuvius stratovolcano, display evidence of gravit - ational instability of wavy bedforms representing the submarine prosecution of pyroclastic flows originated from the Vesuvius during the eruption that destroyed the Roman city of Herculaneum in 79 CE. At the Banco della Montagna, a hummocky seafloor knoll located between the Somma-Vesuvius and the Pozzuoli Bay, seismic profiles and gravity core data revealed the occurrence of a field of volcaniclastic diapirs formed by the dragging and rising up of unconsolidated pumice, as a consequence of fluid overpressure at depth associated with active degassing and fluid venting at the seafloor