Reseñas

Claudia Mónica GARCÍA, Las «fiebres del Magdalena». Medicina y sociedad en la construcción de una noción médica colombiana, 1859-188

Reseñas

Frida GORBACH ; Carlos LÓPEZ BELTRÁN, eds., Saberes locales : ensayos sobre historia de la ciencia en América Latin

Colección y aislamiento de especies vegetales de la provincia de Morona Santiag

La presente investigación está ligada al mejoramiento y racionalización de las prácticas medicinales populares que utilizan plantas de la Amazonía ecuatoriana. Este proyecto parte con la investigación de los usos medicinales de plantas que fueron evidenciados en la experiencia docente con los estudiantes Achuar y Shuar, becarios de la Carrera de Tecnología de los Recursos Biológicos Amazónicos y colectadas con ellos en cuatro zonas de la provincia de Morona Santiago. El resultado fue la creación de dos herbarios didácticos en la Universidad Politécnica Salesiana con alrededor de 1.000 especies vegetales colectadas

El rezago social en áreas metropolitanas de México

En México existen grandes lagunas en la producción y análisis de datos a nivel de pequeña escala territorial. Este trabajo propone una metodología que permite estimar el grado de rezago social para las manzanas de las áreas metropolitanas de México. Se retoma la propuesta del Consejo Nacional de Evaluación de la Política de Desarrollo Social (Coneval) y se utiliza el Censo de Población y Vivienda 2010 para ejemplificar su uso para el área metropolitana de Monterrey. Se ofrecen dos versiones complementarias y se encuentra que, en ambos casos, la proporción de la población que sufre de un grado de rezago social muy alto es considerablemente mayor a la presentada por el Coneval. ABSTRACT Large gaps exist in Mexico about production and analysis of smallscale territorial units. The paper addresses a new methodology for estimating the social backwardness for blocks of the metropolitan areas in Mexico. Based on The National Council for Evaluation of Social Development Policy (Coneval) methodology and using the 2010 Population and Housing Census, as an example, we estimate the index of social backwardness for blocks in the Monterrey metropolitan area. We have implemented two versions to compute the index and both of them suggest the rate of the population suffering from Very High social backwardness is substantially different rate from that presented by Coneva

TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

In recent times, high-throughput screening analyses have broadly defined the RNA cellular targets of TDP-43, a nuclear factor involved in neurodegeneration. A common outcome of all these studies is that changing the expression levels of this protein can alter the expression of several hundred RNAs within cells. What still remains to be clarified is which changes represent direct cellular targets of TDP-43 or just secondary variations due to the general role played by this protein in RNA metabolism. Using an HTS-based splicing junction analysis we identified at least six bona fide splicing events that are consistent with being controlled by TDP-43. Validation of the data, both in neuronal and non-neuronal cell lines demonstrated that TDP-43 substantially alters the levels of isoform expression in four genes potentially important for neuropathology: MADD/IG20, STAG2, FNIP1 and BRD8. For MADD/IG20 and STAG2, these changes could also be confirmed at the protein level. These alterations were also observed in a cellular model that successfully mimics TDP-43 loss of function effects following its aggregation. Most importantly, our study demonstrates that cell cycle alterations induced by TDP-43 knockdown can be recovered by restoring the STAG2, an important component of the cohesin complex, normal splicing profile

Beyond First/Last Mile Active Transportation - BikeShare@UH

Bike sharing is a new green transportation solution that has been developed and adopted at various cities around the world. In this paper, we present the process and results of the design and prototypes that a group of undergraduate students developed for a BikeShare@UH program during Summer 2017. After presenting the detailed results of four project teams focusing on customer discovery, bike share station (BSS) location identification, cloud-based mobile computing platform for user engagement and bike share program operation and management, smart lock, and alternative energy source based on PV panel. With the phase one implementation at the University planned in Spring 2018, we anticipate gathering real time data and feedback to improve the system.Cockrell School of Engineerin

Self-inflicted wound with a nail in the heart: case report

Adequate diagnosis and treatment of penetrating cardiac injury (PCI) represents a great challenge for the surgeon in the emergency department (ED) because of its high mortality. It is estimated that more than 90% of mortality happens before the patient reaches the hospital and only 15---50% of those will receive appropriate medical treatment. Case report: A 42-year-old hemodynamically stable male is brought to the ED with a protruding nail in his thorax. He is taken to the operating room (OR) where a medial sternotomy is performed and an injury is found in the left ventricle. Cardiac muscle repair is performed with pericardial patch. Discussion: PCI from a suicide attempt secondary to a nail hammered into the chest is very rare and no previous reports were found by the author. Conclusion: The objects that penetrate cardiac structures must be removed in a proper OR with capable personnel and the resources available to perform procedures like an urgent thoracotomy or sternotomy