Stefano Ghidinelli, L’interazione poetica. Modi di socializzazione e forme della testualità della poesia italiana contemporanea

Recensiamo Ghidinelli, Stefano. L’interazione poetica. Modi e forme della testualità della poesia italiana contemporanea. Napoli: Guida Editori, 2013. Stampa

Analiticity of the Lyapunov exponent of perturbed toral automorphisms

We consider a dynamical system generated by a perturbation $A_\varepsilon$ of an analytic Anosov diffeomorphism $A_0$ of $\mathbb{T}^d$. We show that, if $A_0$ admit a decomposition of $\mathrm T\mathbb T^d$ in $k$ invariant subspaces, such a decomposition can be extended in an analytic way to $A_\varepsilon$. This implies that the Lyapunov exponents, if non degenerate, are analytic functions of the perturbation

Adult-type rhabdomyoma of the larynx: clinicopathologic study of an uncommon tumor in a rare location

Rhabdomyoma is an uncommon benign mesenchymal tumor with skeletal muscle differentiation that may occur either in the heart or in extra-cardiac sites. Even though the head and neck region is the most common area of extra-cardiac rhabdomyoma, the larynx is rarely involved. We present the case of an 85-year-old woman who reported a 10-day history of breathing difficulties, dysphagia and dysphonia. A computed tomography scan of the head and neck showed a contrast-enhanced, solid hypopharyngeal-laryngeal neoplasm with well-defined margins causing subtotal obliteration of the right pyriform sinus and a reduction in air lumen of the laryngeal vestibule. The patient underwent complete endoscopic removal of the lesion; histologic examination revealed an adult- type rhabdomyoma based on the histologic features and the immunoreactivity of the neoplastic cells for desmin, myoglobin and muscle-specific actin but not for cytokeratin, S-100, CD68R, chromogranin-A and synaptophysin. Since clinical and imaging features are not specific for rhabdomyoma, histologic examination and immunohistochemical analyses play a central role in the differential diagnosis of the adult-type rhabdomyoma from other laryngeal neoplasms. A correct diagnosis is mandatory to avoid inappropriate treatment

High resolution spectroscopy in the XUV with pairs of mutually coherent and time-delayed laser harmonics

We present a Ramsey technique using high-order harmonics for high-resolution atomic spectroscopy in the extreme ultraviolet. Pairs of time-delayed and phase-coherent harmonic pulses generated by the interaction of ultrashort and intense laser pulses with a noble gas are used to study excited states of krypton

Advances in geometrical parametrization and reduced order models and methods for computational fluid dynamics problems in applied sciences and engineering: overview and perspectives

Several problems in applied sciences and engineering require reduction techniques in order to allow computational tools to be employed in the daily practice, especially in iterative procedures such as optimization or sensitivity analysis. Reduced order methods need to face increasingly complex problems in computational mechanics, especially into a multiphysics setting. Several issues should be faced: stability of the approximation, efficient treatment of nonlinearities, uniqueness or possible bifurcations of the state solutions, proper coupling between fields, as well as offline-online computing, computational savings and certification of errors as measure of accuracy. Moreover, efficient geometrical parametrization techniques should be devised to efficiently face shape optimization problems, as well as shape reconstruction and shape assimilation problems. A related aspect deals with the management of parametrized interfaces in multiphysics problems, such as fluid-structure interaction problems, and also a domain decomposition based approach for complex parametrized networks. We present some illustrative industrial and biomedical problems as examples of recent advances on methodological developments. \ua9 The author

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as \u3949-Tetrahydrocannabinol (\u3949-THC) and cannabidiol (CBD), and their effects on inflammation and cancer-related pain. The National Cancer Institute (NCI) currently recognizes medicinal C. sativa as an effective treatment for providing relief in a number of symptoms associated with cancer, including pain, loss of appetite, nausea and vomiting, and anxiety. Several studies have described CBD as a multitarget molecule, acting as an adaptogen, and as a modulator, in different ways, depending on the type and location of disequilibrium both in the brain and in the body, mainly interacting with specific receptor proteins CB1 and CB2. CBD is present in both medicinal and fibre-Type C. sativa plants, but, unlike \u3949-THC, it is completely nonpsychoactive. Fibre-Type C. sativa (hemp) differs from medicinal C. sativa, since it contains only few levels of \u3949-THC and high levels of CBD and related nonpsychoactive compounds. In recent years, a number of preclinical researches have been focused on the role of CBD as an anticancer molecule, suggesting CBD (and CBD-like molecules present in the hemp extract) as a possible candidate for future clinical trials. CBD has been found to possess antioxidant activity in many studies, thus suggesting a possible role in the prevention of both neurodegenerative and cardiovascular diseases. In animal models, CBD has been shown to inhibit the progression of several cancer types. Moreover, it has been found that coadministration of CBD and \u3949-THC, followed by radiation therapy, causes an increase of autophagy and apoptosis in cancer cells. In addition, CBD is able to inhibit cell proliferation and to increase apoptosis in different types of cancer models. These activities seem to involve also alternative pathways, such as the interactions with TRPV and GRP55 receptor complexes. Moreover, the finding that the acidic precursor of CBD (cannabidiolic acid, CBDA) is able to inhibit the migration of breast cancer cells and to downregulate the proto-oncogene c-fos and the cyclooxygenase-2 (COX-2) highlights the possibility that CBDA might act on a common pathway of inflammation and cancer mechanisms, which might be responsible for its anticancer activity. In the light of all these findings, in this review we explore the effects and the molecular mechanisms of CBD on inflammation and cancer processes, highlighting also the role of minor cannabinoids and noncannabinoids constituents of \u3949-THC deprived hemp