On particle production for high energy neutrino beams

Analytical formulae for the calculation of secondary particle yields in p-A interactions are given. These formulae can be of great practical importance for fast calculations of neutrino fluxes and for designing new neutrino beam-lines. The formulae are based on a parameterization of the inclusive invariant cross sections for secondary particle production measured in p-Be interactions. Data collected in different energy ranges and kinematic regions are used. The accuracy of the fit to the data with the empirical formulae adopted is within the experimental uncertainties. Prescriptions to extrapolate this parameterization to finite targets and to targets of different materials are given. The results obtained are then used as an input for the simulation of neutrino beams. We show that our approach describes well the main characteristics of measured neutrino spectra at CERN. Thus it may be used in fast simulations aiming at the optimisation of the proposed long-baseline neutrino beams at CERN and FNAL. In particular we will show our predictions for the CNGS beam from CERN to Gran Sasso.Comment: 18 pages, 10 figures. Submitted to The European Physics Journal

Feasibility of high-voltage systems for a very long drift in liquid argon TPCs

Designs of high-voltage (HV) systems for creating a drift electric field in liquid argon TPCs are reviewed. In ongoing experiments systems capable of approx. 100 kV are realised for a drift field of 0.5-1 kV/cm over a length of up to 1.5 m. Two of them having different approaches are presented: (1) the ICARUS-T600 detector having a system consisting of an external power supply, HV feedthroughs and resistive voltage degraders and (2) the ArDM-1t detector having a cryogenic Greinacher HV multiplier inside the liquid argon volume. For a giant scale liquid argon TPC, a system providing 2 MV may be required to attain a drift length of approx. 20 m. Feasibility of such a system is evaluated by extrapolating the existing designs.Comment: 8 pages, 13 figures, to appear in Proc. of 1st International Workshop towards the Giant Liquid Argon Charge Imaging Experiment (GLA2010), Tsukuba (Japan), March 201

Bracket base remnants after orthodontic debonding

Objective: To evaluate whether the debonding procedure leads to restitutio ad integrum of the enamel surface by investigating the presence of enamel within the bracket base remnants after debonding. Materials and Methods: Sixty patients who completed orthodontic treatment with fixed appliances were included. A total of 1068 brackets were microphotographed; the brackets presenting some remnants on the base (n \u200a=\u200a 818) were selected and analyzed with ImageJ software to measure the remnant area. From this population a statistically significant sample (n \u200a=\u200a 100) was observed under a scanning electron microscope to check for the presence of enamel within the remnants. Energy dispersive x-ray spectrometry was also performed to obtain quantitative data. Results: Statistically significant differences in the remnant percentage between arches were observed for incisor and canine brackets (P < .0001 and P \u200a=\u200a .022, respectively). From a morphologic analysis of the scanning electron micrographs the bracket bases were categorized in 3 groups: group A, bases presenting a thin enamel coat (83%); group B, bases showing sizable enamel fragments (7%); group C, bases with no morphologic evidence of enamel presence (10%). Calcium presence was noted on all evaluated brackets under energy dispersive x-ray spectrometry. No significant difference was observed in the Ca/Si ratio between group A (16.21%) and group B (18.77%), whereas the Ca/Si ratio in group C (5.40%) was significantly lower than that of the other groups (P < .323 and P \u200a=\u200a .0001, respectively). Conclusion: The objective of an atraumatic debonding is not achieved yet; in some cases the damage could be clinically relevant

X-linked dominant RPGR gene mutation in a familial Coats angiomatosis

Background: Retinitis Pigmentosa (RP) is the most frequent retinal hereditary disease and every kind of transmission pattern has been described. The genetic etiology of RP is extremely heterogeneous and in the last few years the large application of Next Generation Sequencing (NGS) approaches improved the diagnostic yield, elucidating previously unexplained RP causes and new genotype-phenotype correlations. The objective of this study was to reevaluate a previously reported family affected by Coats’-type RP without genetic diagnosis and to describe the new genetic findings. Case presentation: Cohort, prospective, and single-center observational family case. Three individuals of a family, consisting of a mother and four sons, with a Coats phenotype were revaluated after 25 years of clinical follow-up using visual acuity tests, ophthalmoscopy, Goldmann visual field, electroretinography (ERG), and spectral domain-optical coherence tomography (SD-OCT). Specifically, a RP NGS panel was performed on one member of the family and segregation analysis was required for the other affected and unaffected members. NGS analysis disclosed a RPGR (Retinitis Pigmentosa GTPase Regulator) gene truncating variant segregating with the phenotype in all the three affected members. RPGR mutations are reported as causative of an X-linked RP. Conclusions: This is the first reported family with a Coats’-type RP associated to a RPGR mutation and segregating as a dominant X-linked disease, confirming the hypothesis of the genetic origin of this condition and expanding the phenotypic spectrum of diseases caused by RPGR gene mutations. The Authors suggest RPGR gene screening mutations in patients presenting this phenotype

Exploring the Viability of Utilizing Treated Wastewater as a Sustainable Water Resource for Green Hydrogen Generation Using Solid Oxide Electrolysis Cells (SOECs)

In response to the European Union's initiative toward achieving carbon neutrality, the utilization of water electrolysis for hydrogen production has emerged as a promising avenue for decarbonizing current energy systems. Among the various approaches, Solid Oxide Electrolysis Cell (SOEC) presents an attractive solution, especially due to its potential to utilize impure water sources. This study focuses on modeling a SOEC supplied with four distinct streams of treated municipal wastewaters, using the Aspen Plus software. Through the simulation analysis, it was determined that two of the wastewater streams could be effectively evaporated and treated within the cell, without generating waste liquids containing excessive pollutant concentrations. Specifically, by evaporating 27% of the first current and 10% of the second, it was estimated that 26.2 kg/m(3) and 9.7 kg/m(3) of green hydrogen could be produced, respectively. Considering the EU's target for Italy is to have 5 GW of installed power capacity by 2030 and the mass flowrate of the analyzed wastewater streams, this hydrogen production could meet anywhere from 0.4% to 20% of Italy's projected electricity demand