Labraunda 2016

La mission 2016 de Labraunda s’est déroulée du 10 juillet au 17 septembre 2016. Les événements politiques turcs qui se sont déroulés peu après le début des opérations, s’ils ont eu un certain impact sur la fouille, avec notamment le renoncement de quelques participants, n’ont toutefois pas désorganisé les travaux prévus. Dans la lignée des années précédentes, nous avons travaillé, avec succès, d’une part à la consolidation de notre implantation locale, par des accords de collaboration (avec l..

Nat Genet

The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.Comment in : Genetic differential calculus. [Nat Genet. 2015] Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015

Rôle vecteur des diptères hématophages chez les ruminants

De nombreuses maladies des ruminants dues à des virus, des bactéries, des protozoaires et des helminthes sont transmises par des diptères hématophages de par le monde. Ces transmissions peuvent être biologiques, l'insecte occupe une place dans le développement de l'agent pathogène ; et mécaniques, le diptère est simple transporteur de sang. L'importance de ces maladies rend essentiel le contrôle de leurs vecteurs.NANTES-Ecole Nat.Vétérinaire (441092302) / SudocSudocFranceF

Eye-in-hand / eye-to-hand cooperation for visual servoing

The use of a camera in a robot control loop can be performed with two types of architecture: the camera is said eye-in-hand when rigidly mounted on the robot end-effector and it is said eyeto-hand when it observes the robot within its work space. These two schemes have technical differences and they can play very complementary parts. Obviously, the eye-in-hand one has a partial but precise sight of the scene whereas the eye-to-hand camera has a less precise but global sight of it. The motivation of our work is to take advantage of both, free-standing and robotmounted sensors, in a cooperation scheme. The system we present in this paper performs two separate tasks: a positioning one that is ensured in the global image and a tracking one performed in the local image. For robustness considerations, the control law stability is proved and several cooperative schemes are studied and compared in experimental results.

TDCIAMS (Thermal Desorption Chemical Ionization Aerosol Mass Spectrometer) (analyse en ligne de l'aérosol organique - développement et applications)

Cette étude s'inscrit dans une problématique globale d'analyse en ligne de la composition chimique de l'Aérosol Organique Secondaire (AOS) pour une meilleure compréhension de sa formation et de son vieillissement, à travers le développement d'un spectromètre de masse à désorption thermique et ionisation chimique : le TDCIAMS. La caractérisation des performances de cet instrument, ainsi que l'étude de l'AOS formé par ozonolyse de l'a-pinène en chambre de simulation atmosphérique (CSA) ont montré que le TDCIAMS est bien adapté à l'analyse quantitative de l'AOS formé en CSA. Les données recueillies par le TDCIAMS permettent d'accéder à des informations essentielles concernant les mécanismes de formation et l'évolution de l'AOS. De plus, l'étude de l'AOS formé par ozonolyse de deux composés d'origine anthropique (2-méthylstyrène et indène), peu étudiés jusqu'alors, a été comparée avec celle réalisée par une analyse off-line (SFE-GC-MS).AIX-MARSEILLE1-BU Sci.St Charles (130552104) / SudocSudocFranceF

Automatic HOA Mixing

International audienc

Eye-in-hand/Eye-to-hand Cooperation for Visual Servoing

The use of a camera in a robot control loop can be performed with two types of architecture: the camera is said eye-in-hand when rigidly mounted on the robot end-effector and it is said eyeto -hand when it observes the robot within its work space. These two schemes have technical differences and they can play very complementary parts. Obviously, the eye-in-hand one has a partial but precise sight of the scene whereas the eye-to-hand camera has a less precise but global sight of it. The motivation of our work is to take advantage of both, free-standing and robotmounted sensors, in a cooperation scheme. The system we present in this paper performs two separate tasks: a positioning one that is ensured in the global image and a tracking one performed in the local image. For robustness considerations, the control law stability is proved and several cooperative schemes are studied and compared in experimental results

Carboxylic acid functional group analysis using constant neutral loss scanning-mass spectrometry

International audienc

Lichtheimia corymbifera Colonization Leading to Pulmonary Infection Can Be Prevented with Liposomal Amphotericin B in a New Murine Model

International audienceThe incidence of pulmonary mucormycosis is constantly increasing, especially in hematological patients staying in high-efficiency particulate air-filtered rooms. Pulmonary inhalation of spores may occur outside the hospital, leading to invasive disease once patients received chemotherapies. We developed a new pulmonary mucormycosis mouse model mimicking the expected pathophysiology in human to study antifungal drugs. Naive mice were inoculated intratracheally with Lichtheimia corymbifera spores. After 3 days, mice received corticosteroids and cyclophosphamide and secondarily developed the disease, while only 5% of the initial inoculum was present in the lungs at day 3. Lung colonization with L. corymbifera spores in immunocompetent mice can last at least 44 days. Antifungal drug was administered the day of immunosuppression. Injection of a single 15 mg/kg of body weight dose of liposomal amphotericin B significantly improved survival and pulmonary fungal burden compared with controls, whereas 80 mg/kg oral posaconazole did not. These results show that a unique dose of liposomal amphotericin B offers a real potential decolonization treatment to prevent infection in our mouse model of L. corymbifera lung colonization followed by lung infection