Outcome of children hospitalized with community‐acquired pneumonia treated with aqueous penicillin G

OBJECTIVE: To describe the evolution and outcome of children hospitalized with community-acquired pneumonia receiving penicillin. METHODS: A search was carried out for all hospitalized community-acquired pneumonia cases in a 37-month period. Inclusion criteria comprised age >2 months, intravenous penicillin G use at 200,000 IU/kg/day for >48 h and chest x-ray results. Confounders leading to exclusion included underlying debilitating or chronic pulmonary illnesses, nosocomial pneumonia or transference to another hospital. Pneumonia was confirmed if a pulmonary infiltrate or pleural effusion was described by an independent radiologist blind to the clinical information. Data on admission and evolution were entered on a standardized form. RESULTS: Of 154 studied cases, 123 (80%) and 40 (26%) had pulmonary infiltrate or pleural effusion, respectively. Penicilli was substituted by other antibiotics in 28 (18%) patients, in whom the sole significant decrease was in the frequency of tachypnea from the first to the second day of treatment (86% vs. 50%, p = 0.008). Among patients treated exclusively with penicillin G, fever (46% vs. 26%, p = 0.002), tachypnea (74% vs. 59%, p = 0.003), chest indrawing (29% vs. 13%, p<0.001) and nasal flaring (10% vs. 1.6%, p = 0.001) frequencies significantly decreased from admission to the first day of treatment. Patients treated with other antimicrobial agents stayed longer in the hospital than those treated solely with penicillin G (16±6 vs. 8±4 days, p<0.001, mean difference (95% confidence interval) 8 (6-10)). None of the studied patients died. CONCLUSION: Penicillin G successfully treated 82% (126/154) of the study group and improvement was marked on the first day of treatment

Projetos interdisciplinares no ensino superior : análise do ensino e aprendizagem do Cálculo no 1º semestre do 1º ano

This paper objective is to identify and analyze the activities developed by Integrated Master of Industrial Engineering and Management students in a context of Project‐Based Learning (PBL) in the Calculus curricular unit and discusses learning during the interdisciplinary project development thru the first semester of 2012/2013. This research is based on a case study developed in the context of one program of School of Engineering, University of Minho, Portugal. To accomplish this case study were collected and analyzed documents produced by the students such as preliminary and final reports, preliminary and final presentations and feedback reports. The results indicate that Calculus contents were applied a content during the interdisciplinary project. Additionally, it can be said that contents of curricular unit give support to the decisions taken by the students in the production system design (the students’ project objective), showing interest and more contents integration relevance

A relevância do trabalho em equipe num caso de uma equipe interdisciplinar de docentes de primeiro ano de um curso de engenharia

This paper presents part of a broader research and aims to identify and analyze the perceptions of teachers involved with active methodologies, relating to PBL - Project-Based Learning, and the relevance of teamwork in this context. The research presents an exploratory qualitative approach, with data collected through semi-structured interviews with teachers who applied active methodologies since 2004. The interview results showed that the implementation of interdisciplinary projects has proven an effective method for increasing student motivation and consequently to increase their commitment with the learning process, which results in an effective development of technical transversal competences. Collaborative teaching work was considered fundamental for achieving the learning goals defined in the process, and as an opportunity for students to realize the interaction between teachers, tutors and researchers of education, showing that PBL encompasses multiple areas and persons to interact in the project throughout the semester. The teamwork involved strengthens and enhances the results.Este artigo apresenta um recorte de uma investigação mais ampla e tem o objetivo de identificar e analisar a percepção de professores envolvidos com metodologias ativas quanto a relevância em trabalhar com metodologias de aprendizagem baseada em projetos interdisciplinares (PBL – Project-Based Learning) e a relevância em trabalhar em equipa neste contexto. A pesquisa apresentou uma abordagem qualitativa de caráter exploratório, com coleta de dados através de entrevistas semiestruturadas com professores que desde 2004 aplicavam metodologias ativas. Os resultados das entrevistas evidenciaram que a implementação de projetos interdisciplinares tem-se mostrado uma metodologia eficaz para ampliar a motivação dos alunos e o consequente aumento do compromisso com a aprendizagem, que resulta na eficácia do desenvolvimento de competências técnicas e competências transversais. O trabalho colaborativo docente foi apontado como de fundamental importância para atingir os objetivos e também como uma vivência para os alunos perceberem a interação entre professores, tutores e investigadores da educação, pois PBL abarca várias disciplinas a interatuar no projeto durante todo o semestre letivo. O trabalho em equipe fortalece os envolvidos e potencializa os resultados

A pele do Leviatã e a geopolítica do vírus: a noosfera como território político dos afetos

A pandemia trazida pela Covid-19 afetou as relações internacionais e intensificou dinâmicas que já estavam em curso, no mínimo, desde a crise global de 2008. Diz-se que a geopolítica, incorporando as noções entre poder e território, marca o período atual, sob a pecha de uma nova Guerra Fria entre EUA e China. Porém, empregar a geopolítica ainda sob a perspectiva através da qual emerge, ao fim do século XIX, revela-se um flagrante anacronismo incapaz de dar conta das complexidades que se apresentam. Sendo assim, este artigo aborda o problema de perscrutar a diferença apresentada pela política internacional durante a crise da Covid-19. Objetiva-se indicar políticas que norteiam a dinâmica internacional, criando as condições para se construir o amanhã da pandemia. A hipótese central que atravessará as páginas seguir situa-se na concepção de que, em uma geopolítica do vírus, embora a Covid-19 seja engendrada pelos interesses dos atores internacionais, a disputa de poder ocorre através de outro “território” denominado noosfera. Em uma análise qualitativa, por meio de revisão bibliográfica, situa-se o surgimento da geopolítica e como ela se insere na dinâmica política global; explica-se o conceito de Império, como esboçado por Negri e Hardt e, ante às limitações dessa abordagem, apresenta-se o conceito de noosfera e seus desdobramentos políticos, a partir das obras de Deleuze

Toxic effects of Ricinus communis non-protein trypsin inhibitor on Spodoptera frugiperda (J. E. Smith) (Lepidoptera:Noctuidae)

In the study reported herein, we aimed to isolate a trypsin inhibitor from Ricinus communis leaves through chromatographic and spectrometric techniques and evaluate its toxic effects on the development of Spodoptera frugiperda larvae. Plant extracts were submitted to fractionation in adsorption column. The fraction 10, which showed the highest inhibitory activity, were incorporated into an artificial diet at the concentrations of 0, 0.06, 0.12, 0.25 and 0.5%, and offered to S. frugiperda larvae. Fresh weight of larvae, food consumed and weight of eliminated faeces were registered. Based on these parameters the following nutritional index were calculated: Relative Consumption Rate (RCR), Relative Metabolic Rate (RMR), Relative Growth Rate (RGR), Approximated Digestibility (AD), Efficiency of Ingested Food Conversion (EIC), Efficiency of Digested Food Conversion (EDC) and the Metabolic Cost (100 - EDC). The inhibitor at 0.5% concentration was deleterious to S. frugiperda, extending the larval stage in 11 days, with higher RCR and ECD, and lower RGR, ECI and ECD. Therefore, the trypsin inhibitor from leaves of R. communis affected the S. frugiperda larval development, being promising in studies of alternative and sustainable control methods for lepidopteran pest species.Keywords: Castor beans, enzymatic inhibition, integrated pest management, plant defense against herbivor

Giant Amazonian fish pirarucu (Arapaima gigas): Its viscera as a source of thermostable trypsin

A trypsin was purified from pyloric caeca of pirarucu (Arapaima gigas). the effect of metal ions and protease inhibitors on its activity and its physicochemical and kinetic properties, as well its N-terminal sequence, were determined. A single band (28.0 kDa) was observed by SDS-PAGE. Optimum pH and temperature were 9.0 and 65 degrees C, respectively. the enzyme was stable after incubation for 30 min in a wide pH range (6.0-11.5) and at 55 degrees C. the kinetic parameters K-m, k(cat) and k(cat)/K-m were 0.47 +/- 0.042 mM, 1.33 s(-1) and 2.82 s(-1) mM(-1), respectively, using BApNA as substrate. This activity was shown to be very sensitive to some metal ions, such as Fe2+, Hg2+, Zn2+, Al3+, Pb2+, and was highly inhibited by trypsin inhibitors. the trypsin N-terminal sequence IVGGYECPRNSVPYQ was found. the features of this alkaline peptidase suggest that it may have potential for industrial applications (e.g. food and detergent industries). (C) 2012 Elsevier B.V. All rights reserved.Financiadora de Estudos e Projetos (FINEP/RECAR-CINE)Ministerio da Aquicultura e Pesca (MAP)Empresa brasileira de pesquisa agropecuaria (Embrapa)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao de Apoio a Ciencia e Tecnologia do Estado de Pernambuco (FACEPE)Petroleo do Brasil S/A (PETROBRAS)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Fed Pernambuco, Lab Enzimol LABENZ, Dept Bioquim, BR-50670420 Recife, PE, BrazilUniv Fed Pernambuco, LIKA, BR-50670420 Recife, PE, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biofis, BR-04044020 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Biofis, BR-04044020 São Paulo, BrazilWeb of Scienc