Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Determination of pesticides procymidone, haloxyfop-metil and linuron in carrots by SLE-LTP and GC-MS

A cultura da cenoura tem exigido a utilização cada vez maior de produtos químicos, tais como os inseticidas, os herbicidas e os fungicidas para que se tenham altas produtividades e competitividade no mercado. O uso intensivo e constante desses produtos no controle de pragas, doenças e plantas daninhas, minimiza as perdas, além de aumentar a produtividade e a qualidade da produção agrícola. Apesar dos agrotóxicos apresentarem efeitos benéficos na oferta mundial de alimentos e na maximização econômica das atividades agrícolas, o seu uso pode ocasionar bioacumulação nos alimentos com consequências indesejáveis à saúde do consumidor. Nesse contexto, o objetivo deste trabalho foi validar uma técnica analítica para extração, detecção e quantificação dos pesticidas procimidona, haloxyfop-metil e linuron em amostras de cenoura por meio de extração sólido-líquído e partição a baixa temperatura (ESL-PBT). A primeira parte do trabalho consistiu na otimização da técnica ESL-PBT avaliando o tempo de agitação, tempo de congelamento, razão massa de amostra: volume de solução extratora. O extrato orgânico obtido foi analisado por cromatografia gasosa acoplada ao espectrômetro de massa. Em seguida, realizou-se a validação da técnica por meio do estudo da seletividade, linearidade, limite de detecção e de quantificação e exatidão. Além disso, o monitoramento dos resíduos em estudo foi realizado em vinte amostras de cenoura produzidas no Alto Paranaíba/MG. Observou-se que os parâmetros otimizados para a condução dos experimentos de validação da técnica foram: volume de acetonitrila de 4,0 mL; massa de amostra de 4 g; tempo de agitação de 10 minutos e tempo de refrigeração de 4 h. Quanto à seletividade avaliada no processo de validação, não se observou nenhum interferente como resposta nos tempos de retenções dos analitos de interesse para nenhum dos agrotóxicos. O limite de quantificação alcançado pela metodologia de 0,48 mg.kg-1 para o haloxyfop-metil, 0,69 mg.kg-1 para linuron e 0,65 mg.kg-1 para procimidona é adequado, pois os valores estão abaixo do limite máximo de resíduos preconizados pela legislação de 1,0 mg.kg-1 para linuron e procimidona e 0,0 mg.kg-1 para haloxyfop-metil, pois este agrotóxico não tem o uso permitido nesta cultura. O limite de detecção determinado foi de 0,16 mg.kg -1 para o haloxyfop-metil, 0,20 mg.kg-1 para linuron e 0,23 mg.kg-1 para procimidona. Em relação aos resultados de exatidão, as porcentagens de recuperação foram superiores a 90% resultado satisfatório, visto que em outros trabalhos as porcentagens de recuperação estiveram entre 70 a 120%. Os resultados de precisão foram satisfatórios visto que o coeficiente de variação para os três níveis de concentração utilizados na determinação foram inferiores a 20%, resultado semelhante ao encontrados em trabalhos semelhantes. Por fim, o monitoramento conduzido em amostras de cenoura mostrou teores de procimidona e linuron superiores ao permitido pela Agência Nacional de Vigilância Sanitária (ANVISA). Para haloxyfop-metil, não é permitida a presença de resíduo nas amostras e esse foi encontrado em todas avaliadas. Conclui-se que a técnica ESL-PBT otimizada e validada nesse trabalho resultou em um método simples e eficaz, consumindo uma pequena quantidade de amostra e solvente extrator. Os parâmetros avaliados no processo de validação indicaram que o método ESL-PBT é eficiente para a extração de haloxyfop-metil, lnuron e procimidona em cenoura.The culture of carrot has required increasing use of chemicals, such as insecticides, herbicides and fungicides so that they have high productivity and market competitiveness. The intensive and continuous use of these products on controlling pests, diseases and weeds, minimizes losses while increasing productivity and quality of agricultural production. Despite the benefits pesticides present in the world's food supply and on maximizing the economic effects of agricultural activities, their use can lead to bioaccumulation in food with undesirable consequences to the health of the consumer. In this context, the aim of this study was to validate an analytical technique for the extraction, detection and quantification of pesticides procymidone, haloxyfop- methyl and linuron in carrot samples by solid-liquid extraction and partition in low temperature. The first part of the work was the optimization technique (SLE-LTP) evaluating the following parameters: agitation time, freezing time, sample mass ratio: volume of extraction solution. The organic extract was analyzed by mass spectrometry coupled to gas chromatography. In consequently, was held to validation the technique for studying the selectivity, linearity, limit of detection and quantification and accuracy. The monitoring of waste study was conducted in twenty carrot samples produced in the Alto Paranaiba / MG. We observed that the optimized parameters for conducting the technical validation experiments were: volume of 4.0 mL of acetonitrile; sample weight 4 g; stirring time of 10 minutes and freezing time of 4h. Regarding the selectivity evaluated in the validation process, observed no interference in response times in the retentions of the analytes of interest for any of the pesticides. The others had a coefficient greater than 0.99, as recommended by ANVISA e USEPA. The limit of quantification achieved by the methodology is appropriate because the valuesare below the maximum residue limit recommended by the legislation. The limit of detection was 0.16 mg.kg -1 for haloxyfop-methyl, 0.20 mg.kg -1 for linuron and 0.23 mg.kg -1 for procymidone. Regarding accuracy results, we can see that the recovery percentages in the three concentration levels tested were higher than 90%. Finally, the monitoring conducted in carrot samples found levels of procymidone and linuron above allowed by ixANVISA. The results were satisfactory accuracy since the coefficient of variation for the three concentration levels used in determining were less than 20%, similar to results found in other studies. For haloxyfop-methyl, the presence of residue in the samples is not permitted and in this work, it has been found in all evaluated. We concluded that the technique optimized and validated in this work resulted in a simple and effective method, consuming a small amount of sample and extracting solvent. The parameters evaluated in the validation process indicated that the method is efficient for the extraction of haloxyfop-methyl, procymidone and linuron in carrots

Effect of N and K doses in nutritive solution on growth, production and coffee bean size

An adequate supply of nutrients is essential for obtaining high yields of coffee. The objective of this study was to evaluate the effect of N, K and the N:K ratio on vegetative and reproductive growth of coffee. For this purpose, coffee plants were grown in nutrient solution containing K in the concentrations of 1.08; 2.15; 3.23 and 5.38 mmol L-1 combined with a dose of 6 mmol L-1 N, resulting in the N:K ratios (w/w): 1:0.5; 1:1; 1:1.5 and 1:2.5. The control treatment consisted of the doses 3 and 1.61 mmol L-1 of N and K respectively, resulting in the N:K ratio (w/w) 1.0:1.5. The following variables were evaluated: height, stem diameter, number of nodes of the eighth plagiotrofic branch (index branch), pairs of plagiotrofic branches and number of nodes in the orthotropic branch every three weeks from the beginning of the experiment. Additionally, it was evaluated the chemical composition of processed beans and leaves between the flowering and the rapid expansion stage of the cherry beans, production of cherry beans per plant and classification of beans according to the size. N influenced mainly the characteristics of vegetative growth and K influenced mainly the reproductive growth evaluated by the production. The lowest production resulted in the highest percentages of beans retained on sieves with holes larger than 16/64", while the highest production promoted an increase in the percentage of beans retained on sieves with holes smaller than 16/64"

Effect of N and K doses in nutritive solution on growth, production and coffee bean size Crescimento, produção e tamanho de grãos de café decorrentes de doses de N e K em solução nutritiva

An adequate supply of nutrients is essential for obtaining high yields of coffee. The objective of this study was to evaluate the effect of N, K and the N:K ratio on vegetative and reproductive growth of coffee. For this purpose, coffee plants were grown in nutrient solution containing K in the concentrations of 1.08; 2.15; 3.23 and 5.38 mmol L-1 combined with a dose of 6 mmol L-1 N, resulting in the N:K ratios (w/w): 1:0.5; 1:1; 1:1.5 and 1:2.5. The control treatment consisted of the doses 3 and 1.61 mmol L-1 of N and K respectively, resulting in the N:K ratio (w/w) 1.0:1.5. The following variables were evaluated: height, stem diameter, number of nodes of the eighth plagiotrofic branch (index branch), pairs of plagiotrofic branches and number of nodes in the orthotropic branch every three weeks from the beginning of the experiment. Additionally, it was evaluated the chemical composition of processed beans and leaves between the flowering and the rapid expansion stage of the cherry beans, production of cherry beans per plant and classification of beans according to the size. N influenced mainly the characteristics of vegetative growth and K influenced mainly the reproductive growth evaluated by the production. The lowest production resulted in the highest percentages of beans retained on sieves with holes larger than 16/64", while the highest production promoted an increase in the percentage of beans retained on sieves with holes smaller than 16/64".O suprimento adequado de nutrientes ao cafeeiro é essencial para obtenção de alta produtividade. O objetivo deste trabalho foi avaliar o efeito do nitrogênio, do potássio e da relação N:K no crescimento vegetativo e reprodutivo do cafeeiro. Para isto, plantas de café receberam solução nutritiva, contendo K nas concentrações de 1,08; 2,15; 3,23 e 5,38 mmol L-1, combinadas com a dose de 6 mmol L-1 de N, obtendo-se as relações N:K (p/p):1,0:0,5; 1,0:1,0; 1,0:1,5; 1,0:2,5. O tratamento controle continha as doses de 3 e 1,61 mmol L-1 de N e K, respectivamente, resultando na relação N:K (p/ p) de 1,0:1,5. Avaliaram-se a altura, o diâmetro do caule, número de nós do oitavo ramo plagiotrópico (ramo índice), o número de pares de ramos plagiotrópicos e o número de nós do ramo ortotrópico a cada três semanas após o início do experimento. Realizaram-se também análises da composição química dos grãos beneficiados e folhas, no período entre a floração e expansão rápida dos frutos, produção de café cereja por planta e classificação dos grãos quanto ao tamanho. O N influenciou principalmente as características de crescimento vegetativo e o K influenciou principalmente as características de crescimento reprodutivo, avaliadas pela produção. A menor produção resultou em percentagens mais elevadas de grãos retidos nas peneiras com crivos maiores que 16/64 polegadas, enquanto a maior produção promoveu aumento na percentagem de grãos retidos nas peneiras com crivos menores que 16/64 polegadas

Determination of Haloxyfop-Methyl, Linuron, and Procymidone pesticides in carrot using SLE-LTP extraction and GC-MS

This study aimed to optimize and validate an analytical method for extraction, detection, and quantification of haloxyfop-methyl, procymidone, and linuron pesticides in carrot samples using solid–liquid extraction methods and low temperature partition (SLE-LTP), accompanied by gas chromatography coupled to mass spectrometry (GC-MS). For SLE-LTP technical optimization, we utilized a complete factorial planning, which had as its variables, agitation time, freezing time, and the correct sample mass/extracting solution volume ratio. The organic extract obtained was analyzed by GC-MS. To test the performance of this procedure, the method was validated and applied to the monitoring of pesticide residues in 20 samples of carrot produced in Alto Paranaíba, Minas Gerais, Brazil. The proposed method showed linearity between 0.5 and 3.5 mg·kg^−1 with correlation coefficients greater than 0.99. The quantification limits were 0.48 mg·kg^−1 for haloxyfop-methyl, 0.69 mg·kg^−1 for linuron, and 0.65 mg·kg^−1 for procymidone, values below the maximum residue limit provided by international legislation of 1.0 mg·kg^−1 for linuron and procymidone. The use of haloxyfop-methyl is not approved in the cultivation of carrot. The recovery percentages were between 90 and 110 %, with a coefficient of variation of less than 12 %. Ten percent of the carrot samples monitored showed residues of linuron and procymidone in concentrations exceeding those permitted by Brazilian law

Memorias: primer encuentro de la RED internacional de investigación en el marco de la X Jornada de Investigación 2019

ERII 2019 es el Primer Encuentro de la Red Internacional Universitaria para el Desarrollo de la Investigación y las Publicaciones Científicas, conformada por la Universidad Católica de Colombia, la Universidad Católica de Salta (Argentina), la Universidad de Monterrey (México) y la Universidad Gabriela Mistral (Chile). Esta red tiene como principal objetivo potenciar el desarrollo de la actividad investigativa, mediante la formalización de redes de investigadores, la promoción de actividades conjuntas, el diseño de planes y movilidad y el trabajo en una red editorial. La actividad académica fue un espacio abierto para compartir experiencias y resultados de investigación no solo de las universidades adscritas a la red, sino de otras instituciones que participaron en el evento. (Tomado de la fuente).1ra ediciónIntroducción ponencias I. Derecho y Ciencias Sociales Análisis del marco institucional vinculado a la implementación de las salvaguardas REDD+ en la Provincia de Salta, Argentina Guadalupe Zapata: intersticios en la construcción histórica fundacional de Pereira, Colombia La notificación por aviso como garantía al debido proceso y tutela judicial efectiva en el proceso monitorio colombiano: análisis en el marco de la Sentencia C-031/2019 Migración y prácticas territoriales de la comunidad boliviana en la ciudad de Salta, Argentina El derecho de infancia y adolescencia en Colombia: reflexiones sobre su estatuto jurídico-doctrinal La soberanía funcional en Colombia para los derechos humanos Agnición de los militares víctimas del conflicto armado en Colombia Elementos politológicos y jurídicos del voto en blanco, el voto nulo y el abstencionismo en las elecciones presidenciales de Ecuador 2017, Costa Rica 2018 y Colombia 2018 La democracia: ¿un fruto envenenado? Una propuesta de jerarquización de las democracias liberales Estudio sobre las relaciones de similitud, causalidad y simbólicas en niños de 3 a 13 años Garantías para el ejercicio de los derechos de los usuarios y estudiantes con discapacidad, enfocado en la inclusión desde el consultorio jurídico de CECAR II. Arte, Arquitectura, Urbanismo y Diseño La industrialización como motor de suburbanización y metropolización de Monterrey, México, en el siglo XX Reivindicación del campesinado desde sus prácticas y saberes: tradiciones en tiempos del posacuerdo en el Sumapaz (Colombia) Diseño geométrico de “calado” para potencializar la ventilación natural en edificaciones El Anfiteatro de la quebrada de Las Conchas: caracterización acústica direccional Estrategia de intervención urbana para la reconfiguración de las redes caminables del borde urbano. Caso de estudio: Sierra Morena, USME Instrumentos musicales del Caribe colombiano en vías de extinción: guandú, arco de boca y marimba de pierna Dispositivos de cambio: intervenciones colectivas en el borde urbano suroriental de Bogotá Creación de nuevos procesos y diseños para la arquitectura de América Latina con la ayuda de indicadores III. Ingeniería y Tecnología Diseño de inclusión tecnológica educativa a través del B-Learning y las TIC Diseño de soluciones tecnológicas a problemas del contexto local en región a través del semillero de investigación TECSIS de la Universidad de Caldas Aplicación de las tecnologías semánticas a la forensia digital: ontología del correo electrónico y su trazabilidad para el análisis forense M-Learning aplicado para estudio de mercados en la formulación de proyectos Análisis en la generación de caudales pico a partir del cambio de la cobertura vegetal en la cuenca Sardinata, departamento del Norte de Santander, Colombia Análisis de impactos ambientales provocados por el aprovechamiento de recursos naturales renovables: metodologías que desarrollan nuevas fuentes generadoras de energía en Panamá y Colombia Aplicación de un modelo unificado para arcillas y arenas a suelos típicos de la ciudad de Salta Estudio técnico para la planeación de la emisora radial de la Universidad Católica de Colombia con migración hacia radio digital La transferencia de las tecnologías limpias en la vivienda social en Brasil y Colombia Desarrollo de un contador Geiger-Müller para verificar la exposición a la radiación en salas de radiología convencional Diseño de un controlador tolerante a fallas en un vehículo de suspensión semiactiva IV. Ciencias de la Salud Biorremediación de residuos peligrosos generados por laboratorios de docencia de la Universidad Colegio Mayor de Cundinamarca Morbilidad en Ecuador, 2007-2016 El desplazamiento del metabolismo de atorvastatina es afectado por los polimorfismos SLCO1B1 y ABCB1 en la población mexicana Terapia ocupacional basada en la evidencia y razonamiento profesional en equipos interdisciplinares de tecnología de apoyo: prótesis impresas en 3D de la Corporación Fabrilab Vicisitudes actuales de la autoridad en las familias de Salta, Argentina Efecto de la lesión por leishmaniasis cutánea (Leishmania braziliensis, Leishmania amazonensis) en el nervio periférico y dermis en ratones Balb/C. Estudio in vivo Diseño y validación del cuestionario de gravedad social percibida del consumo de alcohol en adolescentes Diseño y construcción de una aplicación virtual para rehabilitación auditiva en adultos Revisión sistemática: propiedades psicométricas de los instrumentos utilizados para evaluar las actividades instrumentales de la vida diaria en joven, adulto y persona mayor V. Negocios, Ciencias Económicas y Administrativas Estudio de factibilidad para la conformación de una empresa prestadora de servicios para motocicletas en Manizales Oferta productiva del cacao colombiano en el posconflicto: estrategias para el aprovechamiento de oportunidades comerciales en el marco del acuerdo comercial entre Colombia y la Unión Europea VI. Educación y Humanidades La infantilización del estudiante universitario: origen, situación actual e implicaciones Promoción de competencias socioafectivas en el aula Análisis de la estructura curricular de la Licenciatura en Higiene y Seguridad en el Trabajo: el sistema modular La familia cristiana, una nueva buena para el tercer milenio: los Encuentros Mundiales de las Familias, de Juan Pablo II a Francisco (1994-2018) Perspectivas de la innovación educativa que caracterizan los trabajos de investigación de la Maestría en E-Learning de la Universidad Autónoma de Bucaramanga (Colombia) Análisis de las nuevas tendencias laborales y formativas del trabajador social de Uniminuto (Girardot) Articulación entre la educación religiosa escolar y el derecho a la libertad religiosa Análisis correlacional del aporte de la educación pregradual a la educación secundaria de los egresados del programa de Trabajo Social del 2018 del CRG Uniminuto El aprendizaje en la resignificación de la vida de las infancias Modelo teórico predictor de la retención estudiantil a partir del engagement en la Fundación Universitaria Los Libertadores La letra con sangre entra: castigo permitido en la educación escolar en Bogotá La diferencia en la educación pósteres I. Arte, Arquitectura, Urbanismo y Diseño Restructuración de los paisajes naturales presentes en los bordes urbanos de Bogotá ¿Paisaje, medioambiente y tecnología como bioarquitectura del paisaje? El equipamiento de culto en la construcción del borde urbano de la ciudad II. Ingeniería y Tecnología Nueva matriz para registrar la experiencia consolidada de los oferentes que contratan con el Estado en el sector de la infraestructura vial, en la empresa JOYCO S. A. S Seguridad a un ojo de distancia Sistema de radio sobre fibra para la transmisión de imágenes Estructuras en guadua (quiosco) y bambú (yurta)* Análisis de la utilización de fibras de guadua como refuerzo del concreto Laboratorios con simulación y con equipo real en la enseñanza de redes de computadoras en el nivel universitario Análisis bibliométrico de la correlación existente entre los tópicos de “identificadores de radiofrecuencia” y “gestión de cadena de suministros” como caso de estudio II. Ciencias de la Salud Presencia en manos y conocimiento de Staphylococcus aureus coagulasa positivo en estudiantes de áreas de la salud IV. Educación y Humanidades Del refugio de la virtualidad a la exposición del contacto real Conclusione