24,104 research outputs found

    Sustainability analysis of Chinese transport policy

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    Whilst the world economy is developed, the life and development of human beings have been threatened by the imbalance among environmental and ecological aspects. Thus sustainability is becoming increasingly the focus of various social fields. For most developing countries, a strategy with good sustainability for social development is of long-term significance to keep the economy in expansion. This paper first reviews the conceptual framework and up-to-date development of sustainability. Second, it reviews the current transport situation of China and its future demands. Third, the paper analyses transport policy from the viewpoints of energy consumption and environment pollution caused by transportation. It finally summarises suggestions for transport policy that China should consider in the future

    Neutron star matter in the quark-meson coupling model in strong magnetic fields

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    The effects of strong magnetic fields on neutron star matter are investigated in the quark-meson coupling (QMC) model. The QMC model describes a nuclear many-body system as nonoverlapping MIT bags in which quarks interact through self-consistent exchange of scalar and vector mesons in the mean-field approximation. The results of the QMC model are compared with those obtained in a relativistic mean-field (RMF) model. It is found that quantitative differences exist between the QMC and RMF models, while qualitative trends of the magnetic field effects on the equation of state and composition of neutron star matter are very similar.Comment: 16 pages, 4 figure

    Crystal lattice properties fully determine short-range interaction parameters for alkali and halide ions

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    Accurate models of alkali and halide ions in aqueous solution are necessary for computer simulations of a broad variety of systems. Previous efforts to develop ion force fields have generally focused on reproducing experimental measurements of aqueous solution properties such as hydration free energies and ion-water distribution functions. This dependency limits transferability of the resulting parameters because of the variety and known limitations of water models. We present a solvent-independent approach to calibrating ion parameters based exclusively on crystal lattice properties. Our procedure relies on minimization of lattice sums to calculate lattice energies and interionic distances instead of equilibrium ensemble simulations of dense fluids. The gain in computational efficiency enables simultaneous optimization of all parameters for Li+, Na+, K+, Rb+, Cs+, F-, Cl-, Br-, and I- subject to constraints that enforce consistency with periodic table trends. We demonstrate the method by presenting lattice-derived parameters for the primitive model and the Lennard-Jones model with Lorentz-Berthelot mixing rules. The resulting parameters successfully reproduce the lattice properties used to derive them and are free from the influence of any water model. To assess the transferability of the Lennard-Jones parameters to aqueous systems, we used them to estimate hydration free energies and found that the results were in quantitative agreement with experimentally measured values. These lattice-derived parameters are applicable in simulations where coupling of ion parameters to a particular solvent model is undesirable. The simplicity and low computational demands of the calibration procedure make it suitable for parametrization of crystallizable ions in a variety of force fields.Comment: 9 pages, 5 table

    Microdistribution of oxygen in silicon and its effects on electronic properties

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    The effects of interstitial oxygen on the electrical characteristics of Czochralski-grown silicon crystals were investigated for the first time on a microscale. It was found that the generation of thermal donors is not a direct function of the oxygen concentration. It was further found that the minority carrier life-time decreases with increasing oxygen concentration, on a microscale in as-grown crystals. It was thus shown, again for the first time, that oxygen in as grown crystals is not electronically inert as generally believed. Preannealing at 1200 C commonly employed in device fabrication, was found to suppress the donor generation at 450 C and to decrease the deep level concentrations

    Solvable senescence model with positive mutations

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    We build upon our previous analytical results for the Penna model of senescence to include positive mutations. We investigate whether a small but non-zero positive mutation rate gives qualitatively different results to the traditional Penna model in which no positive mutations are considered. We find that the high-lifespan tail of the distribution is radically changed in structure, but that there is not much effect on the bulk of the population. Th e mortality plateau that we found previously for a stochastic generalization of the Penna model is stable to a small positive mutation rate.Comment: 3 figure

    Zigzag edge modes in Z2 topological insulator: reentrance and completely flat spectrum

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    The spectrum and wave function of helical edge modes in Z_2 topological insulator are derived on a square lattice using Bernevig-Hughes-Zhang (BHZ) model. The BHZ model is characterized by a "mass" term M (k) that is parameterized as M (k) = Delta - B k^2. A topological insulator realizes when the parameters Delta and B fall on the regime, either 0 < Delta /B < 4 or 4 < Delta /B < 8. At Delta /B = 4, which separates the cases of positive and negative (quantized) spin Hall conductivities, the edge modes show a corresponding change that depends on the edge geometry. In the (1,0)-edge, the spectrum of edge mode remains the same against change of Delta /B, although the main location of the mode moves from the zone center for Delta /B < 4, to the zone boundary for Delta /B > 4 of the 1D Brillouin zone. In the (1,1)-edge geometry, the group velocity at the zone center changes sign at Delta /B = 4 where the spectrum becomes independent of the momentum, i.e. flat, over the whole 1D Brillouin zone. Furthermore, for Delta/B < 1.354..., the edge mode starting from the zone center vanishes in an intermediate region of the 1D Brillouin zone, but reenters near the zone boundary, where the energy of the edge mode is marginally below the lowest bulk excitations. On the other hand, the behavior of reentrant mode in real space is indistinguishable from an ordinary edge mode.Comment: 19 pages, 33 figure

    Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway.

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    BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis. The virus-infected mice were treated with the CC chemokine antagonist Met-RANTES or anti-RANTES mAb to determine the role of RANTES in affecting TBEV-induced neurological disease. The underlying signaling mechanisms were delineated using RANTES promoter luciferase reporter assay, siRNA-mediated knockdown, and pharmacological inhibitors in human brain-derived cell culture models. RESULTS: In a mouse model, pathological features including marked inflammatory cell infiltrates were observed in brain sections, which correlated with a robust up-regulation of RANTES within the brain but not in peripheral tissues and sera. Antagonizing RANTES within CNS extended the survival of mice and reduced accumulation of infiltrating cells in the brain after TBEV infection. Through in vitro studies, we show that virus infection up-regulated RANTES production at both mRNA and protein levels in human brain-derived cell lines and primary progenitor-derived astrocytes. Furthermore, IRF-3 pathway appeared to be essential for TBEV-induced RANTES production. Site mutation of an IRF-3-binding motif abrogated the RANTES promoter activity in virus-infected brain cells. Moreover, IRF-3 was activated upon TBEV infection as evidenced by phosphorylation of TBK1 and IRF-3, while blockade of IRF-3 activation drastically reduced virus-induced RANTES expression. CONCLUSIONS: Our findings together provide insights into the molecular mechanism underlying RANTES production induced by TBEV, highlighting its potential importance in the process of neuroinflammatory responses to TBEV infection

    Simultaneous reactive dyeing and surface modification of polyamide fabric with TiOâ‚‚ precursor finish using a one-step hydrothermal process

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    In this article, the approach of dyeing polyamide (PA) fabric by using C.I. Reactive Blue 19 dye and simultaneously modifying it with titanium dioxide precursor under hydrothermal conditions is developed. The anthraquinone-based Reactive Blue 19 dye, which is more resistant to biodegradation owing to its fused aromatic structure compared to an azo-based one, is utilized as a model compound in this research to demonstrate the photodegradation effect of TiOâ‚‚ on reactive dyes. It is shown that a layer of TiOâ‚‚ nanoparticles is homogeneously coated on fiber surfaces and their particle sizes are smaller than those remaining in the residual dyeing liquors. The crystallinity and optical properties of the resultant PA fabrics are changed due to this hydrothermal dyeing process. In comparison with the dyed-only PA fabrics, the PA fabrics dyed and simultaneously modified with anatase TiOâ‚‚ nanoparticles exhibit better color fastness against artificial light (xenon) while maintain similar grades of color fastness against washing with soap, wet scrubbing, dry cleaning as well as dry/wet rubbing. While changes in tensile strength, elongation and water absorbency of the resultant PA fabrics were not found, the addition of tetrabutyl titanate in the dyeing liquor is proved to facilitate the reaction of reactive dye with PA fabric and the resultant PA fabric shade. More interestingly, it is noticed that the residual dyeing liquor can be photodegraded after 50 mins of either UV or visible light irradiation, and the dyeing wastewater can thus be released in an eco-friendly manner to the environment
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