2,211 research outputs found
Bis(2-methoxyphenolato-κ2 O,O′)copper(II)
In the title compound, [Cu(C7H7O2)2], the asymmetric unit contains one and a half molecules with the central Cu(II) atoms situated on a general position and on a centre of inversion, respectively. Both Cu(II) atoms show a similar slightly distorted square-planar coordination, resulting from four O atoms of two 2-methoxyphenolate anions
Expression of soluble vascular endothelial growth factor receptor-1 and placental growth factor in fetal growth restriction cases and intervention effect of tetramethylpyrazine
AbstractObjectiveTo investigate the expression of soluble vascular endothelial growth factor receptor-1 (sFlt-1) and placental growth factor (PLGF) in the fetal growth restriction (FGR) cases and the intervention mechanism of tetramethylpyrazine.MethodsA total of 60 fetal growth restriction cases that admitted to our hospital were randomly divided into ligustrazine intervention group (group A) and nutritional support group (group B). A total of 50 healthy pregnant women were also enrolled as control group (group C). Expression level of maternal serum sFlt1, PLGF and fetal growth parameters including HC, AC, FL, BPD, EFW as well as placenta PLGF, sFlt-1 mRNA expression were recorded and compared among the three groups. A total of 15 SD rats were selected and were divided into three groups, TMP group, alcohol and tobacco group and blank control group. Three groups of rats were dissected on the twentieth day of gestation.ResultsExpression level of sFlt-1 and PLGF in group A was not significantly different from that of group C (P>0.05); but significant difference in SFlt1 and PLGF expression level was observed between group C and group B (P<0.05). Before treatment, HC, AC, FL, BPD and EFW of group A and group B were significant lower than those of group C, but after treatment, those parameters in group A were significantly improved (P<0.05). In the animal experiment there was no significant difference in sFlt-1 between treatment group and FGR group without treatment or control group (P>0.05). There was significant difference in PLGF between FGR group with treatment and FGR group without treatment or control group (P<0.01).ConclusionsPLGF level is decreased and sFlt-1 increased in patients suffered from fetal growth restriction, and FGR rats show increased sFlt-1 and decreased PLGF, thus they can be indicator of the fetal growth restriction. Ligustrazine can effectively improve sFlt-1, PLGF expression level in fetal growth restriction cases, which can be used as treatment for FGR
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All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A.
Patients with type 1 diabetes mellitus are associated with impairment in vitamin A metabolism. This study evaluated whether treatment with retinoic acid, the biologically active metabolite of vitamin A, can ameliorate diabetes. All-trans retinoic acid (atRA) was used to treat streptozotocin (STZ)-induced diabetic mice which revealed atRA administration ameliorated blood glucose levels of diabetic mice. This hyperglycemic amelioration was accompanied by an increase in the amount of β cells co-expressed Pdx1 and insulin and by restoration of the vascular laminin expression. The atRA-induced production of vascular endothelial growth factor-A from the pancreatic islets was possibly the key factor that mediated the restoration of islet vascularity and recovery of β-cell mass. Furthermore, the combination of islet transplantation and atRA administration significantly rescued hyperglycemia in diabetic mice. These findings suggest that vitamin A derivatives can potentially be used as a supplementary treatment to improve diabetes management and glycemic control
Phase transformation-induced improvement in hardness and high-temperature wear resistance of plasma-sprayed and remelted NiCrBSi/WC coatings
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. The remelting method is introduced to improve the properties of the as-sprayed NiCrBSi coatings. In this work, tungsten carbide (WC) was selected as reinforcement and the as-sprayed and remelted NiCrBSi/WC composite coatings were investigated by X-ray diffraction, scanning electron microscopy, hardness test and tribology test. After spraying, WC particles are evenly distributed in the coating. The remelting process induced the decarburizing reaction of WC, resulting in the formation of dispersed W2 C. The dispersed W2 C particles play an important role in the dispersion strengthening. Meanwhile, the pores and lamellar structures are eliminated in the remelted NiCrBSi/WC composite coating. Due to these two advantages, the hardness and the high-temperature wear resistance of the remelted NiCrBSi/WC composite coating are significantly improved compared with those with an as-sprayed NiCrBSi coating; the as-sprayed NiCrBSi coating, as-sprayed NiCrBSi/WC composite coating and remelted NiCrBSi/WC composite coating have average hardness of 673.82 HV, 785.14 HV, 1061.23 HV, and their friction coefficients are 0.3418, 0.3261, 0.2431, respectively. The wear volume of the remelted NiCrBSi/WC composite coating is only one-third of that of the as-sprayed NiCrBSi coating
Insights into the Ecological Roles and Evolution of Methyl-Coenzyme M Reductase-Containing Hot Spring Archaea
Several recent studies have shown the presence of genes for the key enzyme associated with archaeal methane/alkane metabolism, methyl-coenzyme M reductase (Mcr), in metagenome-assembled genomes (MAGs) divergent to existing archaeal lineages. Here, we study the mcr-containing archaeal MAGs from several hot springs, which reveal further expansion in the diversity of archaeal organisms performing methane/alkane metabolism. Significantly, an MAG basal to organisms from the phylum Thaumarchaeota that contains mcr genes, but not those for ammonia oxidation or aerobic metabolism, is identified. Together, our phylogenetic analyses and ancestral state reconstructions suggest a mostly vertical evolution of mcrABG genes among methanogens and methanotrophs, along with frequent horizontal gene transfer of mcr genes between alkanotrophs. Analysis of all mcr-containing archaeal MAGs/genomes suggests a hydrothermal origin for these microorganisms based on optimal growth temperature predictions. These results also suggest methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor
Almost sure state estimation with H2-type performance constraints for nonlinear hybrid stochastic systems
This paper is concerned with the problem of almost sure state estimation for general nonlinear hybrid stochastic systems whose coefficients only satisfy local Lipschitz conditions. By utilizing the stopping time method combined with martingale inequalities, a theoretical framework is established for analyzing the so-called almost surely asymptotic stability of the addressed system. Within such a theoretical framework, some sufficient conditions are derived under which the estimation dynamics is almost sure asymptotically stable and the upper bound of estimation error is also determined. Furthermore, a suboptimal state estimator is obtained by solving an optimization problem in the H2 sense. According to the obtained results, for a class of special nonlinear hybrid stochastic systems, the corresponding conditions reduce to a set of matrix inequalities for the purpose of easy implementation. Finally, two numerical simulation examples are used to demonstrate the effectiveness of the results derived.This work was supported in part by the National Natural Science Foundation of China under Grants 61134009 and 61329301, the Royal Society of the UK, and the Alexander von Humboldt Foundation of Germany
Almost sure H∞ sliding mode control for nonlinear stochastic systems with Markovian switching and time-delays
This paperinvestigatesthealmostsure H1 sliding mode control (SMC) problem for non linear stochastic systems with Markovian switching and time-delays. An integral sliding surface is first constructed for the addressed system. Then, by employing the topping time method combined with martingale in equalities, sufficient conditions are established to ensure the almost surely exponential stability and the H 1 performance of the system dynamics in the specified sliding surface. ASMC law is designed to guarantee the reach ability of the specified sliding surface almost surely. Furthermore, the obtained results are applied to a class of special nonlinear stochastic systems with Markovian switching and time-delays, where the desired SMC law is obtained in terms of the solutions to a set of matrix in equalities. Finally, a numerical example is given to show the effectiveness of the proposed SMC scheme
Observation of nonrelativistic plaid-like spin splitting in a noncoplanar antiferromagnet
Spatial, momentum and energy separation of electronic spins in condensed
matter systems guides the development of novel devices where spin-polarized
current is generated and manipulated. Recent attention on a set of previously
overlooked symmetry operations in magnetic materials leads to the emergence of
a new type of spin splitting besides the well-studied Zeeman, Rashba and
Dresselhaus effects, enabling giant and momentum dependent spin polarization of
energy bands on selected antiferromagnets independent of relativistic
spin-orbit interaction. Despite the ever-growing theoretical predictions, the
direct spectroscopic proof of such spin splitting is still lacking. Here, we
provide solid spectroscopic and computational evidence for the existence of
such materials. In the noncoplanar antiferromagnet MnTe, the in-plane
components of spin are found to be antisymmetric about the high-symmetry planes
of the Brillouin zone, comprising a plaid-like spin texture in the
antiferromagnetic ground state. Such an unconventional spin pattern, further
found to diminish at the high-temperature paramagnetic state, stems from the
intrinsic antiferromagnetic order instead of the relativistic spin-orbit
coupling. Our finding demonstrates a new type of spin-momentum locking with a
nonrelativistic origin, placing antiferromagnetic spintronics on a firm basis
and paving the way for studying exotic quantum phenomena in related materials.Comment: Version 2, 30 pages, 4 main figures and 8 supporting figure
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