Inteligencia emocional y logro de aprendizaje en matemática de los estudiantes de educación secundaria de la I.E. Trilce Comas de la ugel 04 - 2013

La investigación consideró como objetivo general “determinar la relación que existe entre la Inteligencia Emocional y el logro de aprendizaje en Matemática de los estudiantes de Educación Secundaria de la I.E. TRILCE Comas de la UGEL 04 - 2013”. Su propósito está orientado a beneficiar alumnos y docentes de educación secundaria mediante el estudio de una relación existente entre la inteligencia emocional y el desarrollo de habilidades cognitivas referentes al área de Matemática según lo establecido por el DCN (Diseño Curricular Nacional) y el Proyecto Educativo Nacional al 2021 (PEN). Es una investigación descriptiva correlacional de diseño no experimental, en la cual se trabajó con 213 alumnos que corresponden a la muestra elegida de educación secundaria de la I.E. Trilce Comas; de los cuales se consideraron a 188 que obtuvieron un resultado consistente al aplicarles el test ICE de Barón para medir la inteligencia emocional, y luego se comparó dichos resultados con sus notas obtenidas según los registros proporcionados por la LE., para luego ser procesados a través del software del SPSS 20.0 aplicándoles el análisis no paramétrico denominado coeficiente de correlación “rho de Spearman”. Finalmente, se concluye que el coeficiente de correlación r=0.828 con una p=0.01 (p < 0.05), permite afirmar que existe relación directa y significativa entre la inteligencia emocional y el logro de aprendizaje en Matemática de los alumnos de educación secundaria de la LE. Trilce Comas de la UGEL 04 - 2013, resaltando que dicho coeficiente hallado es de una magnitud alta

A arquitectura do museu de arte : de arquivo a site-specific

Dissertação de Mestrado Integrado em Arquitectura, apresentada ao Departamento de Arquitectura da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.A arquitectura do museu de arte sofreu, durante as últimas décadas, uma expansão sem precedentes. Arte e Arquitectura lideram o debate em torno da instituição museológica e o conceito de lugar para a arte tem sido reformulado, assistindo-se a uma consolidação do mesmo enquanto elemento marcante no espaço urbano. Entendidos como espaços de memória e preservação da História, aliam a estas funções primordiais a capacidade de se reinventarem no tempo através do cruzamento entre arte e arquitectura. Quando estes dois saberes se intersectam, há uma abrangente possibilidade de estruturas que permitem a fruição do espaço expositivo, assim como das obras de arte que o completam. O estudo de exemplos seleccionados, já inseridos na cidade, resultado de um processo de reintegração no território urbano, permitiram compreender como os paradigmas estudados se verificam, ou não, nestes modelos. A importância desta preferência vai além das premissas inerentes à arquitectura do museu de arte e prende-se com a oportunidade de incidir esta investigação em exemplos menos versados mas não menos interessantes, de escala mais controlada, contrastando com os grandes cânones arquitectónicos. Procurando uma compreensão acerca das relações entre Arte e Arquitectura no espaço expositivo, esta investigação pretende reflectir acerca da vasta possibilidade de espaços gerados por este vínculo e simultaneamente perceber de que forma a arquitectura do museu de arte irá envolver-se na recepção da obra de arte por parte do espectador.Architecture of art museum experienced, during the last decades, an unprecedented expansion. Art and architecture lead the debate around the museum institutions and a concept of a place for art has been redesigned, permitting its consolidation as a striking element in the urban space. Understood as spaces of memory and history preservation, museums combine these primary functions and the ability to reinvent themselves along the time through the intersection between art and architecture. When these two knowledges are intersecting there is a wide possibility of structures which allows enjoying the relationship between the exhibition space and the artworks. The selected case studies of this dissertation, which already were introduced in the city, result of a reintegration process in the urban space, they allowed us to understand how the studied paradigms are perceived, or not, in these practical models. The importance of this preference goes beyond the premises inherent to the architecture of art museum, and it is related with the opportunity to center this investigation in unusual examples, but not least important in opposition to greatest architecture’s canons. Hoping to understand the relationship between art and architecture in the exhibition space, this research proposes to think about the large possibilities created by these spaces and simultaneously understand in which way the architecture of art museum is deeply involved with the viewer

MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma

Background The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both of biomarkers predicting efficacy for therapies in use and of novel efficacious therapeutic agents is crucial to increase patient survival. MAP17 (PDZK1IP1) is a small membrane-bound protein whose upregulation is reported as a common feature in tumours from diverse histological origins. Furthermore, MAP17 is correlated with tumour progression. Go to: Methods We assessed the expression of MAP17 in preclinical models, including cell lines and patient-derived xenografts (PDXs), assessing its correlation with sensitivity to different standard-of-care drugs in lung adenocarcinoma, as well as novel drugs. At the clinical level, we subsequently correlated MAP17 expression in human tumours with patient response to these therapies. Go to: Results We show that MAP17 expression is induced during lung tumourigenesis, particularly in lung adenocarcinomas, and provide in vitro and in vivo evidence that MAP17 levels predict sensitivity to therapies currently under clinical use in adenocarcinoma tumours, including cisplatin, carboplatin and EGFR inhibitors. In addition, we show that MAP17 expression predicts proteasome inhibitor efficacy in this context and that bortezomib, an FDA-approved drug, may be a novel therapeutic approach for MAP17-overexpressing lung adenocarcinomas. Go to: Conclusions Our results indicate a potential prognostic role for MAP17 in lung tumours, with particular relevance in lung adenocarcinomas, and highlight the predictive pot0065ntial of this membrane-associated protein for platinum-based therapy and EGFR inhibitor efficacy. Furthermore, we propose bortezomib treatment as a novel and efficacious therapy for lung adenocarcinomas exhibiting high MAP17 expression

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in some important cellular processes. Numb is a protein involved in cell development, in cell adhesion and migration, in asymmetric cell division, and in targeting proteins for endocytosis and ubiquitination. NumbL exhibits some overlapping functions with Numb, but its role in tumorigenesis is not fully known. Here we showed that the downregulation of NumbL alone is sufficient to increase NICD nuclear translocation and induce Notch pathway activation. Furthermore, NumbL downregulation increases epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-related gene transcripts and CSC-like phenotypes, including an increase in the CSC-like pool. These data suggest that NumbL can act independently as a tumor suppressor gene. Furthermore, an absence of NumbL induces chemoresistance in tumor cells. An analysis of human tumors indicates that NumbL is downregulated in a variable percentage of human tumors, with lower levels of this gene correlated with worse prognosis in colon, breast and lung tumors. Therefore, NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool.España, Ministerio de Economía y Competitividad PI12/00137, PI15/00045España, Consejería de Ciencia e Innovación CTS-6844España, Consejería de Ciencia e Innovación CTS-1848España, Junta de Andalucía, Consejería de Salud PI-0306-2012España, Junta de Andalucía, Consejería de Salud PI-0096-201