A simplicial gauge theory

We provide an action for gauge theories discretized on simplicial meshes, inspired by finite element methods. The action is discretely gauge invariant and we give a proof of consistency. A discrete Noether's theorem that can be applied to our setting, is also proved.Comment: 24 pages. v2: New version includes a longer introduction and a discrete Noether's theorem. v3: Section 4 on Noether's theorem has been expanded with Proposition 8, section 2 has been expanded with a paragraph on standard LGT. v4: Thorough revision with new introduction and more background materia

The engagement of further and higher education with the London 2012 Olympic and Paralympic Games

Podium commissioned the Centre for Sport, Physical Education & Activity Research (SPEAR) at Canterbury Christ Church University to carry out research to capture the engagement of the further and higher education sectors and related stakeholders with the past, current and future opportunities presented by the London 2012 Olympic and Paralympic Games. The full report was released on 15 March 2011 to mark 500 days to go until the start of London 2012

Advances and challenges in umbilical cord blood and tissue bioprocessing: procurement and storage

Umbilical cord tissue and blood is banked to complement the rapidly advancing field of tissue engineering and regenerative medicine for both autologous and allogeneic therapeutic applications. Whilst many problems concerning the use of the hematopoietic and multipotential mesenchymal stromal cells contained therein may be addressed through the future development of GMP-compliant manufacturing strategies, collection and bioprocessing of these tissues can be optimised in the present to maximise clinical outcomes. In this review, we describe current procurement, processing and storage approaches for umbilical cord blood and tissue; current challenges and how these may be met to augment translation and use of therapeutics harnessing their derivatives

Curvature condensation and bifurcation in an elastic shell

We study the formation and evolution of localized geometrical defects in an indented cylindrical elastic shell using a combination of experiment and numerical simulation. We find that as a symmetric localized indentation on a semi-cylindrical shell increases, there is a transition from a global mode of deformation to a localized one which leads to the condensation of curvature along a symmetric parabolic crease. This process introduces a soft mode in the system, converting a load-bearing structure into a hinged, kinematic mechanism. Further indentation leads to twinning wherein the parabolic crease bifurcates into two creases that move apart on either side of the line of symmetry. A qualitative theory captures the main features of the phenomena and leads to sharper questions about the nucleation of these defects.Comment: 4 pages, 5 figures, submitted to Physical Review Letter

What Are the Public Health Effects of Direct-to-Consumer Drug Advertising?

Background to the debate: Only two industrialized countries, the United States and New Zealand, allow direct-to-consumer advertising (DTCA) of prescription medicines, although New Zealand is planning a ban [ 1]. The challenge for these governments is ensuring that DTCA is more beneficial than harmful. Proponents of DTCA argue that it helps to inform the public about available treatments and stimulates appropriate use of drugs for high-priority illnesses (such as statin use in people with ischemic heart disease). Critics argue that the information in the adverts is often biased and misleading, and that DTCA raises prescribing costs without net evidence of health benefits

Light-Cone Quantization of the Liouville Model

We present the quantization of the Liouville model defined in light-cone coordinates in (1,1) signature space. We take advantage of the representation of the Liouville field by the free field of the Backl\"{u}nd transformation and adapt the approch by Braaten, Curtright and Thorn. Quantum operators of the Liouville field $\partial_{+}\phi$, $\partial_{-}\phi$, $e^{g\phi}$, $e^{2g\phi}$ are constructed consistently in terms of the free field. The Liouville model field theory space is found to be restricted to the sector with field momentum $P_{+}=-P_{-}$, $P_{+}> 0$ , which is a closed subspace for the Liouville theory operator algebra.Comment: 16 p, EFI-92-6

Confidential Boosting with Random Linear Classifiers for Outsourced User-generated Data

User-generated data is crucial to predictive modeling in many applications. With a web/mobile/wearable interface, a data owner can continuously record data generated by distributed users and build various predictive models from the data to improve their operations, services, and revenue. Due to the large size and evolving nature of users data, data owners may rely on public cloud service providers (Cloud) for storage and computation scalability. Exposing sensitive user-generated data and advanced analytic models to Cloud raises privacy concerns. We present a confidential learning framework, SecureBoost, for data owners that want to learn predictive models from aggregated user-generated data but offload the storage and computational burden to Cloud without having to worry about protecting the sensitive data. SecureBoost allows users to submit encrypted or randomly masked data to designated Cloud directly. Our framework utilizes random linear classifiers (RLCs) as the base classifiers in the boosting framework to dramatically simplify the design of the proposed confidential boosting protocols, yet still preserve the model quality. A Cryptographic Service Provider (CSP) is used to assist the Cloud's processing, reducing the complexity of the protocol constructions. We present two constructions of SecureBoost: HE+GC and SecSh+GC, using combinations of homomorphic encryption, garbled circuits, and random masking to achieve both security and efficiency. For a boosted model, Cloud learns only the RLCs and the CSP learns only the weights of the RLCs. Finally, the data owner collects the two parts to get the complete model. We conduct extensive experiments to understand the quality of the RLC-based boosting and the cost distribution of the constructions. Our results show that SecureBoost can efficiently learn high-quality boosting models from protected user-generated data

‘Still living with it even though it’s gone’: Using Interpretive Phenomenological Analysis to explore shared experiences of living with and beyond breast, prostate, and colorectal cancer

Purpose: Living with and beyond cancer is an increasingly common experience. While research is uncovering valuable individual experiences of those living with and beyond cancer, it has been argued that this idiographic approach is limited in outlook, reach and impact. This study contributes to the understanding of what it means to live with and beyond cancer by complementing idiographic knowledge with multiple perspectives from a group of participants who are living with and beyond cancer, to explore how individual experiences may be relevant to others. Method: Semi-structured interviews were conducted with people who had received treatment for breast (n = 6), prostate (n = 6) or colorectal cancer (n = 6). Data were analysed using interpretive phenomenological analysis. The early findings were then shared with a wider group of people who had received treatment for breast, prostate or colorectal cancer (n = 26) in six focus groups, to explore whether they had similar experiences. Results: While individual accounts of living with and beyond cancer detail unique features specific to each person's experience, focus group discussions illustrated how participant life worlds interact and overlap. The findings identified thematic similarities within and between individual and group levels and across cancer types. Three super-ordinate themes describe the shared experience of living with and beyond cancer: i) the cancer shock, ii) managing cancer and getting through and iii) getting over cancer. Conclusions: A multiple perspective approach informs our understanding of shared experiences of living with and beyond cancer. This knowledge can be used to direct, design, and deliver relevant supportive cancer care