STABITY INDICATING DISSOLUTION METHOD DEVELOPMENT FOR ESTIMATION OF METHYLDOPA AND HYDROCHLOROTHIAZIDE IN COMBINE DOSAGE FORM

The aim of this work was to develop validate a dissolution test for Methyldopa and Hydrochlorothiazide in combination tablets using spectrophotometric method. The dissolution established conditions were 900 mL of 0.1M HCl pH 1.0 as dissolution medium, using a paddle apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method the areas of solution were recorded at 274-284 nm and266-276 nm for Methyldopa and Hydrochlorothiazide respectively. It can be concluded that the method developed consists in an efficient alternative for assay of dissolution for tablets. The method was validated to meet requirements for a global regulatory filing which includes linearity, precision, accuracy robustness and ruggedness. In addition, filter suitability and drug stability in medium were demonstrated Keywords: In vitro release, Stability, Dissolution study of methyldopa and Hydrochlorothiazide, Spectrophotometry, Area under curve method, Validation

INVESTIGATION OF THE CRITICAL DIRECTION OF SEISMIC FORCE FOR THE ANALYSIS OF R.C.C FRAMES

ABSTRACT A simple method which can be applied in seismic codes to determine the critical angle of seismic incidence is proposed in this paper. Two 4-story reinforced concrete buildings with moment resisting frames, one with square and the other with rectangular plan, have been analysed by Equivalent Static Method of analysis. A set of values from 0 to 90 degrees, with an increment of 10 degrees, have been used for angle of excitation. Buildings' columns have been divided into three main categories, including corner, side, and internal columns, and axial force and bending moment values in different columns, have been investigated in all cases. The results show that the axial forces of columns may exceed the ordinary cases up to 13% by varying the angle of excitation. Each column gets its maximum axial force and moments with a specific angle of excitation, which is not 0 or 90 degree necessarily, and it varies from column to column

Skirmishing Disconcerting Covid-19 by Drug Reassigning

Background: COVID-19 is a most life threatening condition, therefore it is declared a pandemic by WHO as it has affected the whole world. Even though there are many advanced drug discoveries, viral afflictions are a broad area for researchers. Unfortunately, to date, no drug can treat this lethal infection. COVID -19 has raised the death rate crucially; therefore, it needs the reassigning of drugs for the control of affliction. In some cases, it shows that drug reassigning may cause adverse reactions. But in some countries, these drugs manifest fruitful effects for COVID patients. This article focuses on the effective drug moieties found in in-vitro studies. These drug moieties need further clinical testing based on their in-vitro clinical data. These moieties have shown hope as promising drugs for treating the deadly infection. Objective: The current manuscript is prepared with the main objectives of studying the various drugs and their benefits for the preparation of a vaccine for COVID-19 pandemics and studying the clinical trial status of drugs that are in the final stage of vaccine development. Discussion and Conclusion: The vaccine development process is in progress, and has almost reached the final stage. There are drug reassignments for suppressing the COVID-19 by using various drugs such as Remdesivir, Sarilumab, Favipiravir, Tocilizumab, etc.; the whole world suffered a huge loss due to this pandemic, and the wait for the vaccine will be over shortly. </jats:sec

Real Time Entry Prohibition System for Coalmines

This article focuses on the hazardous conditions prevailing in underground coal mines and the decision to prohibit entry, when conditions are adverse. Thus, the ongoing observation framework is helpful for ascertaining the conditions for working in underground coal mines and for essential safety and well-being measures. The advancements in WSN lead to advancements in wireless communications. The various sensors are deployed at the location and sense the environment and provide recent activities of the underground coal mines. The sensors transmit the procured information to the base station, principally the A-D transformation. The sensors can be considered a hub to the base station. Wireless transmission is used to send the data to the user. The designed hardware and software systems are used for the identification of the parameters and as per the thresholds, the decision and the prohibition of workers before entering into the mine is decided. The ML system helps in checking the favorable conditions for working in underground mines. While experimenting, real-time sensor generated data is used.</jats:p