Development of UV spectrophotometric methods and validation for estimation of furosemide in bulk and tablet dosage form by absorbance maxima and Area Under the Curve method

The present work was to develop two simple UV spectrophotometric methods for simultaneous estimation of furosemide (FUR) in bulk and tablet dosage form and validate as per ICH guidelines. Method A is absorption maxima method in which ?max was found to be 277 nm. Method B is area under the curve (AUC) in which area in the wavelength range of 258.40 nm 293.80 nm was selected for analysis of furosemide .Linearity was observed in the concentration range 5-25?g/ml (r2 =0.999) for both the methods. The % assay for the marketed formulation for absorption maxima and area under the curve method was found to be 99.16%, and 99.20% respectively. The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for absorption maxima, and area under the curve was found to be 100.46%, and 100.86% respectively. The developed methods were validated for linearity, precision, accuracy, LOD and LOQ as per ICH guidelines. Both the methods were found to be linear within the conc. Range of 5-25?g/ml for furosemide. The present methods were found to be simple, linear, precise, accurate and sensitive and can be used for routine quality control analysis for the estimation of furosemide in bulk and tablet dosage form

On abstraction refinement for program analyses in Datalog

A central task for a program analysis concerns how to efficiently find a program abstraction that keeps only information relevant for proving properties of interest. We present a new approach for finding such abstractions for program analyses written in Datalog. Our approach is based on counterexample-guided abstraction refinement: when a Datalog analysis run fails using an abstraction, it seeks to generalize the cause of the failure to other abstractions, and pick a new abstraction that avoids a similar failure. Our solution uses a boolean satisfiability formulation that is general, complete, and optimal: it is independent of the Datalog solver, it generalizes the failure of an abstraction to as many other abstractions as possible, and it identifies the cheapest refined abstraction to try next. We show the performance of our approach on a pointer analysis and a typestate analysis, on eight real-world Java benchmark programs

Case study: Anaesthetic management of an achondroplastic dwarf undergoing radical nephrectomy

A three feet two inch (96 cm) tall achondroplastic patient with urothelial cell carcinoma involving renal pelvis was scheduled for a radical nephrectomy. Radial artery cannulation and central venous access were securedin the pre-induction period. After induction, the airway was secured using a flexible fibreoptic scope. General anaesthesia was maintained with oxygen-nitrous-oxide and continuous propofol infusion. The total duration of anaesthesia was three hours and 50 minutes. To the best of the authors’ knowledge, this is the shortest adult achondroplastic patient ever reported to undergo such major abdominal surgery under general anaesthesia. The anaesthetic implications in patients with achondroplasia are reviewed in this case report

DRUG UTILIZATION STUDY IN NEONATAL INTENSIVE CARE UNIT AT RURAL TERTIARY CARE HOSPITAL.

Objectives: To study the trends of drug utilization pattern in neonatal intensive care unit (NICU) at rural tertiary care hospital using the World HealthOrganization core indicators.Methods: The study was cross-sectional, observational study in NICU of Government Medical College, Ambajogai, Maharashtra. Data were collected byscrutinizing the prescriptions written by pediatricians in NICU. The consent of parents of neonate was obtained for inclusion in the study. Parameterssuch as age, gender, birth weight, current illness, congenital anomalies, gestational age at birth, and drugs prescription analyzed.Results: A total 220 prescription were scrutinized. Out of 220 neonates, 53.6% was males and 46.3% females. The total number of drugs prescribedwas 808 and the average number of drugs per prescription was 3.6. The most frequently prescribed therapeutic class of drugs antimicrobial agents(60.64%) followed by vitamin K (26.7%) and aminophylline (9.4%). The maximum number (50%) of neonate born with birth weight <2.5. Themaximum number (42%) of neonate was born at 34-36 weeks of gestation. Preterm low birth weight was the most common observed reason foradmission to NICU. The drugs are prescribed by branded name outnumbered than generic name.Conclusion: This study highlights the problem of overprescribing of antibiotics, inadequate labeling and a trend toward polypharmacy.Keywords: Drug utilization study, Neonatal intensive care unit, Prescription, Neonate

EFFICACY OF AN AYURVEDIC INTERVENTION IN THE MANAGEMENT OF URETERIC CALCULI: A CASE STUDY

Urinary calculi is one of the most common and painful urological disorder of the urinary tract affecting 10-12 % of the population. It is characterized by frequent micturition, intermittent pain occasionally radiates to flanks, sweating and restlessness during the pain. Most of the patients taking allopathic medicine but calculi was not expel or crushed from the urinary tract. Endoscopic procedures such as ureterostomy, percutaneous nephrolithiotomy and extracorporeal shockwave lithotripsy or other surgical procedures is the treatment of choice in case of ureteric calculi in the conventional system. Non-invasive and safe study had designed for the management of this entity. In the present study, An Ayurvedic intervention Chandraprabha Vati (500 mg ) and Swetparpati (250 mg) along with decoction of natural herbs 30 ml twice in a day for 90 days used for ureteric calculi. The response to the treatment is encouraging by symptoms relief and through lower abdomen ultrasonography (USG). Ureteric calculi has expel from the tract through this management.

Finite Element Analysis of Magneto-Rheological Damper

Abstract-In this paper, a finite element analysis of magnetorheological fluid (mr) damper is presented. It is necessary to develop a fem model for calculation of damping force of a given mr damper. An axi-symmetric fem model is thus built on ansys platform to analyze and examine a prototype of the mr damper. In this paper, geometrical parameters and magnetic flux density at the clearance space of the damper are studied. The study has indicated that the fem modeling is effectively portraying the behavior of a mr damper and is adequate enough for estimation of the damping force, its control and design. The results obtained in this paper will be helpful to the future designers to predict the damping force of a given damper

Characterization of Magnetorheological Finishing Fluid for Continuous Flow Finishing Process

Magnetorheological (MR) fluid finishing process is an application of MR technology in which controllability of the MR fluid is used advantageously to finish the workpiece surface. MR finishing fluid changes its stiffness in accordance with the applied magnetic field and hence it behaves like a flexible finishing tool. A relative motion between this tool and workpiece removes the material from the machining surface. The quality of the final finished surface depends on the constituents of the finishing fluid and the applied magnetic field strength as these parameters affect the rheological properties of the fluid. A study on the rheological properties of the fluid at high shear rates is carried out through Taguchi Design of Experiments to characterize its flow behaviour to be used in continuous flow finishing process. Constitutive modeling of the fluid sample is done using Bingham Plastic, Casson Fluid and Herschel Bulkley fluid models to characterize their rheological behavior. The Hershel–Bulkley model is found to be the best suited model for the finishing fluid. Analysis of Variance has revealed that volume percentage of iron particles is the most significant parameter with a contribution of 91.68% on the yield stress and viscosity on the finishing fluid. The highest yield stress of the fluid is observed between magnetic flux density ranges from 0.3 to 0.5 Tesla. An optimised combination is then synthesized to confirm the theoretical results. The effect of temperature is also studied on the optimised fluid which has shown that temperature shares an inverse relation with the yield stress of the finishing fluid