Chloroquine-resistant Plasmodium falciparum in Sokoto, North Western Nigeria

Three patients, 30, 2 and one and a half years, were diagnosed as having falciparum malaria and were placed on chloroquine therapy which failed. They were then placed on quinine therapy that then cleared the parasitaemia. This case report seeks to draw the attention of the presence of possible chloroquine-resistant falciparum malaria in Sokoto, North Western Nigeria. (African Journal of Biotechnology: 2003 2(8): 244-245

Association of intestinal helminthic infection and nutritional status of primary school children in Gombe State, Nigeria

Background: Intestinal helminthic infections are among the commonest infections worldwide. It often affects the poorest communities and has similar geographic distribution with malnutrition. Intestinal helminthic infection contributes to undernutrition through subtle reduction in digestion and absorption of food, chronic inflammation and loss of nutrients. The objective of this study is to determine the prevalence of intestinal helminthic infection and its relationship with nutritional status of primary school children in Gombe, Gombe State, Nigeria. Methodology: This was a cross sectional study of 350 pupils selected through multistage random sampling technique from 24 primary schools in Gombe, Gombe State, Nigeria from July 2018 to January 2019. Demographic information including age, gender, height, and weight were collected from each participant with a designed collection form. The data were analysed using SPSS version 24.0, and presented as frequency distribution and mean ± SD. The Chi-square test (with Odds ratio and 95% confidence interval) was used to test for association between prevalence of helminthiasis and factors such as gender, age group and school type. A p value of less than 0.05 was considered statistically significant at 95% confidence interval. Results: The prevalence of intestinal helminthic infection was 23.7% (83/350). Eighty (96.4%) of the 83 infected pupils were in public schools while only 3 (3.6%) were in private schools (p<0.001). The prevalence of helminthiasis was significantly higher in underweight pupils (34%, OR=2.113, p=0.0065)) and significantly lower (5.4%, OR=0.1637, p=0.0037) in overweight pupils while the prevalence was not significantly associated with normal weight (p=0.5482) or obesity (p=1.000). Conclusions: Intestinal helminthic infection is a public health problem in children with adverse significant relationship with nutritional status. Provision of toilet facilities in schools and periodic de-worming of pupils aimed at reducing loss of nutrients from intestinal helminthiasis are recommended

Control of superluminal transit through a heterogeneous medium

We consider pulse propagation through a two component composite medium (metal inclusions in a dielectric host) with or without cavity mirrors. We show that a very thin slab of such a medium, under conditions of localized plasmon resonance, can lead to significant superluminality with detectable levels of transmitted pulse. A cavity containing the heterogeneous medium is shown to lead to subluminal-to-superluminal transmission depending on the volume fraction of the metal inclusions. The predictions of phase time calculations are verified by explicit calculations of the transmitted pulse shapes. We also demonstrate the independence of the phase time on system width and the volume fraction under specific conditions.Comment: 21 Pages,5 Figures (Published in Journal of Modern Optics

Alloantibodies, Anti-D, Childbearing age, Women, Cameroon

We conducted a cross sectional retrospective study to determine anti-D and D-negative phenotype rates among Cameroonian women of reproductive age (15 – 44 years), in order to evaluate the importance ofD alloimmunization. Analysis of the haematology laboratory records from January 2006 to December 2007 harvested 225 results for red blood cell alloantibody screening and 2460 D phenotypes. Anti-D rate was found to be high at 4% and not linked to women’s parity. Three hundred and fifty two (14.3%) women were found to be D-negative. Anti-D rates significantly decreased with age from 18.8% among teenagers (15-19) to 7.8% among older women (35-44) (p = 0.001). The number of women submitted to both irregular antibody screening and type D phenotype determination was not strong enough (50) to analyse the link between anti-D rate and antigen D distribution in our study (Afr J Reprod Health 2009; 13[3]:47-52)

Primordial metallic melt in the deep mantle

Seismic tomography models reveal two large low shear velocity provinces (LLSVPs) that identify large-scale variations in temperature and composition in the deep mantle. Other characteristics include elevated density, elevated bulk sound speed, and sharp boundaries. We show that properties of LLSVPs can be explained by the presence of small quantities (0.3–3%) of suspended, dense Fe-Ni-S liquid. Trapping of metallic liquid is demonstrated to be likely during the crystallization of a dense basal magma ocean, and retention of such melts is consistent with currently available experimental constraints. Calculated seismic velocities and densities of lower mantle material containing low-abundance metallic liquids match the observed LLSVP properties. Small quantities of metallic liquids trapped at depth provide a natural explanation for primitive noble gas signatures in plume-related magmas. Our model hence provides a mechanism for generating large-scale chemical heterogeneities in Earth's early history and makes clear predictions for future tests of our hypothesis

Risk factors and outcomes of contrast-induced nephropathy in hospitalised South Africans

Background. Despite ranking third as a cause of hospital-acquired acute kidney injury (AKI), iatrogenic contrast-induced nephropathy (CIN) impacts significantly on morbidity and mortality and is associated with high hospital costs. In  sub-Saharan Africa, the rates and risk factors for CIN and patient outcomes remain unexplored.Methods. We conducted a prospective observational study at the Charlotte Maxeke Johannesburg Academic Hospital, South Africa, from 1 July 2014 to 30 July 2015. Hospitalised patients undergoing computed tomography scan contrast media administration and angiography were consecutively recruited to the study and followed up for development of AKI. CIN was defined as an increase in serum creatinine >25% or an absolute increase of >44 μmol/L from baseline at 48 - 72 hours post exposure to contrast media. Outcome variables were the occurrence of CIN, length of hospitalisation and in-hospital mortality.Results. We recruited 371 hospitalised patients with a mean (standard deviation) age of 49.3 (15.9). The rates of CIN, assessed using an absolute or relative increase in serum creatinine from baseline, were 4.6% and 16.4%, respectively. Anaemia was an independent predictor for the development of CIN (risk ratio (RR) 1.71, 95% confidence interval (CI) 1.01 - 2.87; p=0.04). The median serum  albumin was 34 g/L (interquartile range (IQR) 29 - 39.5) and 38 g/L (IQR 31 - 42) in the CIN and control groups, respectively (p=0.01), and showed a significant trend for CIN development (RR 1.68, 95% CI 0.96 - 2.92; p=0.06). Mortality was  significantly increased in the CIN group (22.4% v. 6.8%; p<0.001), and CIN  together with anaemia increased mortality twofold (RR 2.39, 95% CI 1.20 - 4.75; p=0.01) and threefold (RR 3.32, 95% CI 1.48 - 7.43; p=0.003), respectively.Conclusions. CIN has a relatively high incidence in sub-Saharan Africa and predicts poorer clinical outcomes. The presence of CIN and anaemia positively predicted mortality. Caution should be exercised in patients with hypoalbuminaemia and anaemia undergoing contrast media administration

Cocoa marketing chain in developing countries: how do formal-informal linkages ensure its sustainability in Cameroon?

Open Access Article; Published online: 10 Oct 2020Although liberalization of the cocoa sector has increased internal competition within the marketing chain it has also led to the emergence of informal market actors within the chain. Therefore, the aim of this paper is to analyse how the cocoa marketing chain operates by measuring and comparing the marketing margins of the formal and informal actors. Qualitative data were used to establish the structure of the marketing chain and quantitative data to estimate the marketing margins. A total sampling size of 76 cocoa market actors was obtained by using a multi-stage sampling technique: 15 for qualitative data and 61 for quantitative data. Descriptive analysis was used to map the marketing chain and economic analysis to compute the costs and margins for both informal and formal market intermediaries from the Centre and South-West regions in Cameroon. The results indicated three market intermediaries (one informal and two formal) and four marketing channels by which cocoa moves from the farmers to the exporters. The calculation of marketing costs indicated that informal actors incurred the highest costs in both regions. The results regarding the marketing margins were twofold: informal actors obtain low net marketing margins when they do not use illicit strategies, but high net marketing margins when illicit strategies are used. Given the significant role of informal actors, we suggest that their actions should be integrated in a suitable manner into those of formal actors to contribute to a better performance of the marketing chain and to the sustainability of the cocoa sector