Monitoring of the habitat usage of Tembadau (Bos javanicus lowi) around salt lick in a forest plantation of Sabah, Malaysia

Enn HS, Musta B, Sarjadi MS, Maid M, Muning M, Kodoh J, Goh C, Jonalius M, Sompud J. 2022. Monitoring of the habitat usage of Tembadau (Bos javanicus lowi) around salt lick in a forest plantation of Sabah, Malaysia. Biodiversitas 23: 6062-6069. Tembadau (Bos javanicus lowi) is a wild cattle endemic to Borneo Island, especially in Sabah, Malaysia. Their population is declining due to habitat loss and illegal hunting. Previous researchers have reported that hunting pressure and forest fragmentation due to the conversion of natural forests into oil palm plantations are driving the species into the looming extinction of this species. Tembadau is well known for using the salt lick in its habitat. Salt licks are rich in minerals, or feeding sites are important as critical temporal use for wildlife, including Tembadau. The lack of data on the ecological behavior of Tembadau in salt lick areas caused difficulties in monitoring their population in the forest. It may undermine their conservation, especially in the forest plantations. The habitat usage of the Tembadau in this study was expressed in the detection rate and activity pattern. This study aimed to compare Tembadau’s detection rate at salt and non-salt lick areas in a forest plantation situated at the Segaliud Lokan Forest Reserve, Sandakan, Sabah. The activity pattern of Tembadau between a salt lick and non-salt lick areas was also determined. A camera trap survey was carried out from 2 November 2019 to 6 September 2020 to collect the presence, absence and activity pattern of Tembadau. The results show that the detection rate of Tembadau was higher in salt licks, especially salt lick C59SL (n: 171, U: 3187.5, p: 0.003). Tembadau at the salt licks expressed all diurnal, nocturnal and crepuscular behavior but was primarily active at night (n: 12, 43% of nocturnal behavior). Salt licks are beneficial for wildlife to provide the essential elements of intake, health and reproductive success. These findings are helpful information for the monitoring and further conservation work for the species, especially in forest plantation areas. It also provides essential baseline data for lawmakers to make policies for the total protection of salt licks in forest plantations

Bornean Pygmy Elephant habitat usage of natural salt licks in Segaliud Lokan Forest Reserve

Bornean pygmy elephant (Elephas maximus borneensis) is crucial in the forests ecosystem as it plays a vital role as a forest engineer. As such, it is crucial to conduct more research to contribute to the conservation of this species. This study examined the pygmy elephant usage of natural salt lick in Segaliud Lokan Forest Reserve (SLFR), also known as FMU19B. Salt lick is vital to maintain wildlife health. This study investigated the elephant's visitation frequency and examined its activity pattern in the natural salt lick area. A camera trap survey was conducted from November 2019 till August 2020. Four natural salt licks (C50SL, C56SL, C59SL and C60SL), and three non-salt licks (C50NSL, C56NSL, and C59&C60NSL) was selected. The data were analysed using descriptive and statistical analysis. The results show a higher visitation frequency at the salt lick area than the non-salt lick area (p<0.01). The salt lick at C59 was the most frequently visited by the elephant. The activity pattern displayed by the Bornean pygmy elephant shows a higher degree of nocturnal activity (73.3%). This information is essential for the timber concession forest managers to design the conservation work for the species in balancing with the timber extraction activity

Measuring children’s involvement as an indicator of curriculum effectiveness : a curriculum evaluation of a selected child study centre in Singapore

This paper presents one aspect of a research project evaluating a curriculum model of a selected child study centre in Singapore. An issue of worldwide interest and concern is the &lsquo;quality of learning&rsquo; debate as it relates to early childhood centres. In Singapore, the government is focusing on expansion in child care settings and increases in the amount of funded training. One of the issues surrounding prior-to-school education raises the question of how one measures the quality of teaching and learning, to describe the value of using, funding and promoting early education. The research reported in this study used a quasi experimental research paradigm to assess one aspect of the quality of a curriculum programme in a child study centre in Singapore. Children aged between 18 months and 6 years (N = 81) participated in the research. Using the observation scale of Laevers&rsquo; Child Involvement Scale, the active involvement of children in learning experiences was measured. The findings are presented and discussed

Vibration-Controlled Transient Elastography Scores to Predict Liver-Related Events in Steatotic Liver Disease

Importance Metabolic dysfunction–associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis.Objective To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)–based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD.Design, Setting, and Participants This cohort study included data from a natural history cohort of patients with MASLD who underwent VCTE examination at 16 tertiary referral centers in the US, Europe, and Asia from February 2004 to January 2023, of which the data were collected prospectively at 14 centers. Eligible patients were adults aged at least 18 years with hepatic steatosis diagnosed by histologic methods (steatosis in ≥5% of hepatocytes) or imaging studies (ultrasonography, computed tomography or magnetic resonance imaging, or controlled attenuation parameter ≥248 dB/m by VCTE).Main Outcomes and Measures The primary outcome was liver-related events (LREs), defined as hepatocellular carcinoma or hepatic decompensation (ascites, variceal hemorrhage, hepatic encephalopathy, or hepatorenal syndrome), liver transplant, and liver-related deaths. The Agile scores were compared with histologic and 8 other noninvasive tests.Results A total of 16 603 patients underwent VCTE examination at baseline (mean [SD] age, 52.5 [13.7] years; 9600 [57.8%] were male). At a median follow-up of 51.7 (IQR, 25.2-85.2) months, 316 patients (1.9%) developed LREs. Both Agile 3+ and Agile 4 scores classified fewer patients between the low and high cutoffs than most fibrosis scores and achieved the highest discriminatory power in predicting LREs (integrated area under the time-dependent receiver-operating characteristic curve, 0.89). A total of 10 920 patients (65.8%) had repeated VCTE examination at a median interval of 15 (IQR, 11.3-27.7) months and were included in the serial analysis. A total of 81.9% of patients (7208 of 8810) had stable Agile 3+ scores and 92.6% of patients (8163 of 8810) had stable Agile 4 scores (same risk categories at both assessments). The incidence of LREs was 0.6 per 1000 person-years in patients with persistently low Agile 3+ scores and 30.1 per 1000 person-years in patients with persistently high Agile 3+ scores. In patients with high Agile 3+ score at baseline, a decrease in the score by more than 20% was associated with substantial reduction in the risk of LREs. A similar trend was observed for the Agile 4 score, although it missed more LREs in the low-risk group.Conclusions and Relevance Findings of this study suggest that single or serial Agile scores are highly accurate in predicting LREs in patients with MASLD, making them suitable alternatives to liver biopsy in routine clinical practice and in phase 2b and 3 clinical trials for steatohepatitis

Global impacts of Covid-19 on lifestyles and health and preparation preferences: an international survey of 30 countries

Background: The health area being greatest impacted by coronavirus disease 2019 (COVID-19) and residents' perspective to better prepare for future pandemic remain unknown. We aimed to assess and make cross-country and cross-region comparisons of the global impacts of COVID-19 and preparation preferences of pandemic. Methods: We recruited adults in 30 countries covering all World Health Organization (WHO) regions from July 2020 to August 2021. 5 Likert-point scales were used to measure their perceived change in 32 aspects due to COVID-19 (-2 = substantially reduced to 2 = substantially increased) and perceived importance of 13 preparations (1 = not important to 5 = extremely important). Samples were stratified by age and gender in the corresponding countries. Multidimensional preference analysis displays disparities between 30 countries, WHO regions, economic development levels, and COVID-19 severity levels. Results: 16 512 adults participated, with 10 351 females. Among 32 aspects of impact, the most affected were having a meal at home (mean (m) = 0.84, standard error (SE) = 0.01), cooking at home (m = 0.78, SE = 0.01), social activities (m = -0.68, SE = 0.01), duration of screen time (m = 0.67, SE = 0.01), and duration of sitting (m = 0.59, SE = 0.01). Alcohol (m = -0.36, SE = 0.01) and tobacco (m = -0.38, SE = 0.01) consumption declined moderately. Among 13 preparations, respondents rated medicine delivery (m = 3.50, SE = 0.01), getting prescribed medicine in a hospital visit / follow-up in a community pharmacy (m = 3.37, SE = 0.01), and online shopping (m = 3.33, SE = 0.02) as the most important. The multidimensional preference analysis showed the European Region, Region of the Americas, Western Pacific Region and countries with a high-income level or medium to high COVID-19 severity were more adversely impacted on sitting and screen time duration and social activities, whereas other regions and countries experienced more cooking and eating at home. Countries with a high-income level or medium to high COVID-19 severity reported higher perceived mental burden and emotional distress. Except for low- and lower-middle-income countries, medicine delivery was always prioritised. Conclusions: Global increasing sitting and screen time and limiting social activities deserve as much attention as mental health. Besides, the pandemic has ushered in a notable enhancement in lifestyle of home cooking and eating, while simultaneously reducing the consumption of tobacco and alcohol. A health care system and technological infrastructure that facilitate medicine delivery, medicine prescription, and online shopping are priorities for coping with future pandemics

A Research Study on Secure Attachment Using the PrimaryCaregiving Approach

A child’s positive sense of well-being is central to their overall growth and development. With an increasing number of mothers in the workforce, many infants and toddlers spend much time in child care services. Hence it is crucial that caregivers provide a secure base for the child to develop secure attachment with educarers. Given multiple caregivers, fostering attachment in the child care setting can be problematic. One strategy used in some countries is the implementation of a primary caregiving system. The purpose of this research study was to investigate how caregivers in two childcare centres in Singapore implemented the primary caregiving system. A ‘before-and-after’ methodology was used to find out if change had occurred after the intervention. Results showed that attachment in infants/toddlers had strengthened through the improved educaring practices, collaboration with families, staff team work and employment stability

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AML) per year. Donor graft-versus-leukemia (GVL) effect can prevent AML relapse; however, alloSCT is limited by significant toxicity related to conditioning intensity, immunosuppression, opportunistic infections, and graft-versus-host disease (GVHD). Reducing the intensity of conditioning regimens prior to alloSCT has improved their tolerability, but does not alter the pattern of GVHD and has been associated with increased rates of graft rejection and relapse. Here, using a murine pre-clinical model, we describe a novel recipient conditioning approach combining reduced intensity conditioning with either genetic or pharmacological inhibition of NK cell numbers that permits efficient donor engraftment and promotes GVL without inducing GVHD. We show that NK cell-specific deletion of Bcl2 or Mcl1 in mice, or pharmacological inhibition of BCL2 impairs radio-resistant NK cell-mediated rejection of allogeneic engraftment and allows reduction of conditioning intensity below that associated with GVHD priming. The combination of reduced intensity conditioning and NK cell targeting in mice allowed successful donor T cell engraftment and protective immunity against AML while avoiding GVHD. These findings suggest that reduced conditioning in combination with targeted therapies against recipient NK cells may allow the delivery of effective alloSCT against AML while reducing the toxicities associated with more intensive conditioning including GVHD

Flying Start NHS™: easing the transition from student to registered health professional: Transition from student to registered practitioner

Aims and objectives. To evaluate the impact and effectiveness of Flying Start NHS™ on the confidence, competence and career development of newly qualified practitioners.Background. The first year of practice as a registered nurse, midwife, or allied health professional is recognised as challenging. This paper presents the findings of a two‐year evaluation of Flying Start NHS™, a web‐based programme developed by NHS Education Scotland to support newly qualified health professionals during the transition from student to qualified practitioner.Design. Descriptive design with one to one and focus group interviews, plus a survey.Methods. The evaluation employed a multi‐method approach including telephone interviews with Flying Start NHS™ leads/coordinators (n=21) and mentors (n=22) and focus groups with newly qualified practitioners (nn=95). An online survey was completed by 547 newly qualified practitioners.Results. A majority of newly qualified practitioners reported that Flying Start NHS™ had been useful in terms of clinical skills development and confidence. Those who were able to take protected time were more likely to complete the learning units and report that the support they received was good. Both newly qualified practitioners and mentors reported a lack of time. Newly qualified practitioners who took up posts in the community expressed greater satisfaction with the support received.Conclusions. NHS Boards should ensure that there is an ethos of support at all levels, as well as an understanding of the purpose of Flying Start NHS™ and what newly qualified practitioners require to do to complete it. The expectation that newly qualified practitioners will enrol on Flying Start NHS™ should be accompanied by an expectation that they will complete the programme in their first year, coupled with support to enable them to do so.Relevance to clinical practice. Undertaking Flying Start NHS™ in the first year of employment increases clinical skills development and confidence. Mentors require training and time to enable them to provide support