4,494 research outputs found
Rejection of randomly coinciding events in ZnMoO scintillating bolometers
Random coincidence of events (particularly from two neutrino double beta
decay) could be one of the main sources of background in the search for
neutrinoless double beta decay with cryogenic bolometers due to their poor time
resolution. Pulse-shape discrimination by using front edge analysis, mean-time
and methods was applied to discriminate randomly coinciding events in
ZnMoO cryogenic scintillating bolometers. These events can be effectively
rejected at the level of 99% by the analysis of the heat signals with rise-time
of about 14 ms and signal-to-noise ratio of 900, and at the level of 92% by the
analysis of the light signals with rise-time of about 3 ms and signal-to-noise
ratio of 30, under the requirement to detect 95% of single events. These
rejection efficiencies are compatible with extremely low background levels in
the region of interest of neutrinoless double beta decay of Mo for
enriched ZnMoO detectors, of the order of counts/(y keV kg).
Pulse-shape parameters have been chosen on the basis of the performance of a
real massive ZnMoO scintillating bolometer. Importance of the
signal-to-noise ratio, correct finding of the signal start and choice of an
appropriate sampling frequency are discussed
Representing and analysing molecular and cellular function in the computer
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era. The complexity of biological systems is such that this cannot be envisaged without the help of powerful computer systems capable of representing and analysing the intricate networks of physical and functional interactions between the different cellular components. In this review we try to provide the reader with an appreciation of where we stand in this regard. We discuss some of the inherent problems in describing the different facets of biological function, give an overview of how information on function is currently represented in the major biological databases, and describe different systems for organising and categorising the functions of gene products. In a second part, we present a new general data model, currently under development, which describes information on molecular function and cellular processes in a rigorous manner. The model is capable of representing a large variety of biochemical processes, including metabolic pathways, regulation of gene expression and signal transduction. It also incorporates taxonomies for categorising molecular entities, interactions and processes, and it offers means of viewing the information at different levels of resolution, and dealing with incomplete knowledge. The data model has been implemented in the database on protein function and cellular processes 'aMAZE' (http://www.ebi.ac.uk/research/pfbp/), which presently covers metabolic pathways and their regulation. Several tools for querying, displaying, and performing analyses on such pathways are briefly described in order to illustrate the practical applications enabled by the model
Studies of vertical wind profiles at Cape Kennedy, Florida Final report
Vertical wind profiles spectral analysis and numerical wind forecasts at Cape Kenned
Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity. Little is known about the contribution of individual rhombomeres and their associated Hox codes to auditory sensorimotor circuitry. Here, we show that r4 contributes to functionally linked sensory and motor components, including the ventral nucleus of lateral lemniscus, posterior ventral cochlear nuclei (VCN), and motor olivocochlear neurons. Assembly of the r4-derived auditory components is involved in sound perception and depends on regulatory interactions between Hoxb1 and Hoxb2. Indeed, in Hoxb1 and Hoxb2 mutant mice the transmission of low-level auditory stimuli is lost, resulting in hearing impairments. On the other hand, Hoxa2 regulates the Rig1 axon guidance receptor and controls contralateral projections from the anterior VCN to the medial nucleus of the trapezoid body, a circuit involved in sound localization. Thus, individual rhombomeres and their associated Hox codes control the assembly of distinct functionally segregated sub-circuits in the developing auditory brainstem
Microcephaly and macrocephaly. A study on anthropometric and clinical data from 308 subjects
Head circumference is the auxological parameter that most correlates with developmental anomalies in childhood. Head circumference (HC) two standard deviations (SD) below or above the mean defines microcephaly and macrocephaly, respectively. The aim of this retrospective study was to explore anthropometric parameters and clinical characteristics among subjects with abnormalities in HC who had been referred for developmental assessment. One hundred and sixty four subjects with microcephaly and 144 subjects with macrocephaly were enrolled from birth to 18 months of age. Head circumference at birth and the association with variables related to maternal health status, gestational age, growth pattern, brain imaging and clinical characteristics were analyzed. In some cases, an etiological diagnosis was made. In the two considered conditions, we found different anthropometric and clinical associations, some of which were statistically significant, with implications for ongoing neurodevelopmental surveillance
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