ELECTRICAL STIMULATION OF THE TRICEPS SURAE FOR MUSCULAR STRENGTH IMPROVEMENT IN VOLLEYBALL PLAYERS.

INTRODUCTION Beside the studies carried out at "CentrO Scoliosi" of Istituto Ortopedico "Gaetano Pini" about idiopathic scoliosis pathogenesis (Dacquino et al., 1970) and its treatment using the electrical stimulation (Crivellini and Divieti, 1972, 1975; Crivellini et al., 1976, 1979; Divieti, 1979), an experiment was carried out to analyze the muscular strength increase, obtained by means of the same stimulation procedure for the scoliotic patients. The triceps surae muscle was chosen because of its size and accessibility. The electrical stimulation was performed on a group of subjects not involved in any sporting activity by Caiulo et al., 1980b. This study has shown that electrical stimulation increased the maximum spontaneous force (J 1.9%), the jumping index (23.7%) measured with the Abalakov method (Kots and Xvilon, 1971; Kots et al., 1971), and the maximum limb circumference (6%) measured near the belly of the stimulated muscle. Moreover this experience has shown that the stimulation of the whole gastrocnemius muscle, with well tolerable current values, causes not only the contraction of the triceps surae muscle but also the contraction of the posterior tibialis muscle, normally quite difficult to stimulate because it is deeply positioned under the soleus muscle. In this work the force of the triceps surae was transduced by means of a particular experimental device. The force of this muscle is measurable considering the action of the foot during the flexion movement. The same experiment was repeated on a group of athletes of a volleyball team in order to compare the results. It is important to note that the electrical stimulation first recruits the big superficial motor units that are the last activated in maximal voluntary contractions

Enhanced disengagement of auditory attention and phonological skills in action video gamers

Video games play a major role in the everyday life of children, teenagers, and adults. Several studies show that action video games (AVGs) improve visual attentional efficiency. AVGs also appear to improve reading speed and phonological skills in children with developmental dyslexia. These results have been linked to the intrinsic characteristics of AVGs, in which fast disengagement of multisensory attention allows for efficient extraction of relevant dynamic information, a skill that is crucially also involved in phonological and reading skills. We tested the hypothesis that AVG players demonstrate faster auditory attention disengagement in an auditory spatial cuing task, as well as better phonological and reading performance than non-players. We found that AVG players were faster in spatial localization of auditory targets and showed enhanced attentional disengagement as indexed by a smaller cuing effect. AVG players also showed better phonological decoding and working memory skills. Moreover, the beneficial effects of AVGs, as measured by faster attentional disengagement, were linked to better phonological and reading skills in adult AVG players. We suggest that a more efficient attentional disengagement - controlled by the posterior parietal cortex - induces enhanced multisensory processing in AVG players

LONG TERM IMPROVEMENT OF PERFORMANCE INDEXES IN BASKETBALL PLAYERS

In the present paper measurements and tests were carried out on 12 basketball players of a D-series team, undergoing muscular strengthen, for a period of more than 2 years. The team was divided into 2 groups : the control group, composed of 5 players undergoing only team-training, and the experimental group, composed of 7 players undergoing team-training and sinusoidal electrical stimulation to increase the power in quadriceps femoris and triceps surae . In this study a sinusoidal current at the frequency of 2500 Hz has been used. A stimulation time of 10 seconds was chosen, followed by a rest period of 50 seconds to avoid a reduction of the subsequent contraction force. This stimulation procedure was applied to the subjects of the experimental group for 20 minutes per day for 15days. Four stimulation cycles of 15 days were globally performed using the 4channel electrical stimulator mod. ST-E4C.Similar anthropometric data characterised the two groups : for the experimental group the mean age was 20.1 f 1.9 years, the mean height was 187.7 f 5.0 an and the mean weight 83.8 f 6.4 Kg for the control group these values were respectively 20.8 f 2.5 years, 189.0 f 2.8 cm, 80.6 f 3.7 Kg .Before and after each stimulation cycle, at the beginning and at the end of the agonistic season several tests were performed to evaluate performance indexes :1. Abalakov test (taking the best result of three tests);2. Standing long jump (taking the best result of three tests);3.30 meters dash (taking the average time of three tests).This study has shown that a h26 months the experimental group reached increments of performance indexes twice greater than the control group. After summer, before the beginning of the agonistic season, the absolute increments for the experimental group remained higher than the control group, suggesting that the improvement of the muscular performance by means of sinusoidal electrical stimulation is maintained by a normal training and constitutes a basic resource for the following improvements

Application of Technological System Based on Processes Modelling and Analysis: A Case Study in Italian Aquaculture Company

In recent years, cause of several scandals and incidents in agrifood context, consumer awareness about food product increased. That evolution of the consumer triggers new demand about transparency/accountability by the market. Food industry can face the emerging issues considering traceability principles. A traceability system could support the food companies to maneuver in the complex network of the supply chain and, simultaneously, to answer to the new consumer and market needs. In this work a theoretical approach based on business process modelling was proposed and tested in a real case study. Through an interview and using BPMN technique, the cherry cultivation process of a food companies was modelled. Each activities and actors involved in cultivation was identified in order to detect data stored in different source and format. These data could be strategical if elaborated and transmitted to different stakeholder of the supply chain

Searching for Primordial Black Holes with the Einstein Telescope: impact of design and systematics

Primordial Black Holes (PBHs) have recently attracted much attention as they may explain some of the LIGO/Virgo/KAGRA observations and significantly contribute to the dark matter in our universe. The next generation of Gravitational Wave (GW) detectors will have the unique opportunity to set stringent bounds on this putative population of objects. Focusing on the Einstein Telescope (ET), in this paper we analyse in detail the impact of systematics and different detector designs on our future capability of observing key quantities that would allow us to discover and/or constrain a population of PBH mergers. We also perform a population analysis, with a mass and redshift distribution compatible with the current observational bounds. Our results indicate that ET alone can reach an exquisite level of accuracy on the key observables considered, as well as detect up to tens of thousands of PBH binaries per year, but for some key signatures (in particular high--redshift sources) the cryogenic instrument optimised for low frequencies turns out to be crucial, both for the number of observations and the error on the parameters reconstruction. As far as the detector geometry is concerned, we find that a network consisting of two separated L--shaped interferometers of 15 (20)~km arm length, oriented at $45^{\circ}$ with respect to each other performs better than a single triangular shaped instrument of 10 (15)~km arm length, for all the metrics considered.Comment: 24 pages, 13 figure

Intraventricular liponeurocytoma: The role of surgery and adjuvant therapy

Background: After a series of case reports, in the WHO classification of 2007, liponeurocytomas were reclassified as grade II tumors and confirmed in the last WHO classification of 2016. We describe a rare case of intraventricular location of liponeurocytoma with review of the literature and propose the management of these rare lesions. Methods: We reviewed the pertinent english literature and extracted 9 articles to discuss 12 cases of intraventricular liponeurocytoma. We reported demographics and clinical data cases including our case. Results: Patients mean age is 37years. There is a male prevalence. All 12 patients underwent surgical treatment. A total tumor resection was obtained in 66,6%. There is one mortality reported due to intraventricular hemorrhage. In 4 cases K67/MIB-1 resulted 3% after subtotal removal. Keywords: Liponeurocytoma, Fourth ventricle, Ki-67 index, Neurocytom

Fabrication of high-resolution strain sensors based on wafer-level vacuum packaged MEMS resonators

The paper reports on the fabrication and characterization of high-resolution strain sensors for structural materials based on Silicon On Insulator flexural resonators manufactured by polysilicon Low-Pressure Chemical Vapour Deposition vacuum packaging. The sensors present sensitivity of 164 Hz/με and strain resolution limit of 150 pε on steel for a measurement time of 315 ms, in both tensile and compressive strain regimes. The readout of the sensor is implemented with a transimpedance oscillator circuit implemented on Printed Circuit Board, in which a microcontroller-based reciprocal frequency counter is integrated. The performance of the sensors on steel are investigated for measurement bandwidths from 1.5 to 500 Hz and a comparison with conventional metal strain gauges is proposed.The contribution of Mr. Filippo Bonafè, Mr. Fabrizio Tamarri, Mr. Michele Sanmartin and Mr. Giulio Pizzochero in the clean room processing employed for the manufacturing of the MEMS sensors is acknowledged. The contribution of Dr. Michele Bellettato in sample preparation is also acknowledged.This is the author accepted manuscript. The final version is available from Elsevier via http://dx.doi.org/10.1016/j.sna.2016.01.00

Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis

Ewing sarcoma (EWS) is the second most common bone and soft tissue-associated malignancy in children and young adults. It is driven by the fusion oncogene EWS/FLI1 and characterized by rapid growth and early metastasis. We have previously discovered that the mRNA binding protein IGF2BP3 constitutes an important biomarker for EWS as high expression of IGF2BP3 in primary tumors predicts poor prognosis of EWS patients. We additionally demonstrated that IGF2BP3 enhances anchorage-independent growth and migration of EWS cells suggesting that IGF2BP3 might work as molecular driver and predictor of EWS progression. The aim of this study was to further define the role of IGF2BP3 in EWS progression. We demonstrated that high IGF2BP3 mRNA expression levels correlated with EWS metastasis and disease progression in well-characterized EWS tumor specimens. EWS tumors with high IGF2BP3 levels were characterized by a specific gene signature enriched in chemokine-mediated signaling pathways. We also discovered that IGF2BP3 regulated the expression of CXCR4 through CD164. Significantly, CD164 and CXCR4 colocalized at the plasma membrane of EWS cells upon CXCL12 stimulation. We further demonstrated that IGF2BP3, CD164, and CXCR4 expression levels correlated in clinical samples and the IGF2BP3/CD164/CXCR4 signaling pathway promoted motility of EWS cells in response to CXCL12 and under hypoxia conditions. The data presented identified CD164 and CXCR4 as novel IGF2BP3 downstream functional effectors indicating that the IGF2BP3/CD164/CXCR4 oncogenic axis may work as critical modulator of EWS aggressiveness. In addition, IGF2BP3, CD164, and CXCR4 expression levels may constitute a novel biomarker panel predictive of EWS progression