277 research outputs found
The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia
Background Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension. Methods Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20–68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography. Results Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with GP18 (P \u3c 0.05/57). The canonical correlation analysis indicated that initial N-glycan structures, including GP4, GP6, GP9-12, GP14, GP17, GP18 and GP23, were significantly correlated with blood lipids, including total cholesterol, total triglycerides (TG) and low-density lipoprotein (r = 0.390, P \u3c 0.001). IgG glycans patterns were able to distinguish patients with dyslipidaemia from the controls, with an area under the curve of 0.692 (95% confidence interval 0.644–0.740). Conclusions Our findings indicated that a possible association between blood lipids and the observed loss of galactose and sialic acid, as well as the addition of bisecting GlcNAcs, which might be related to the chronic inflammation accompanying with the development and procession of dyslipidaemia
The LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap I. The Spectroscopic Redshift Catalog
We present a spectroscopic redshift catalog from the LAMOST Complete
Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap
(SGC), which is designed to observe all sources (Galactic and extra-galactic)
by using repeating observations with a limiting magnitude of in
two fields. The project is mainly focusing on the completeness of
LAMOST ExtraGAlactic Surveys (LEGAS) in the SGC, the deficiencies of source
selection methods and the basic performance parameters of LAMOST telescope. In
both fields, more than 95% of galaxies have been observed. A post-processing
has been applied to LAMOST 1D spectrum to remove the majority of remaining sky
background residuals. More than 10,000 spectra have been visually inspected to
measure the redshift by using combinations of different emission/absorption
features with uncertainty of . In total, there are 1528
redshifts (623 absorption and 905 emission line galaxies) in Field A and 1570
redshifts (569 absorption and 1001 emission line galaxies) in Field B have been
measured. The results show that it is possible to derive redshift from low SNR
galaxies with our post-processing and visual inspection. Our analysis also
indicates that up to 1/4 of the input targets for a typical extra-galactic
spectroscopic survey might be unreliable. The multi-wavelength data analysis
shows that the majority of mid-infrared-detected absorption (91.3%) and
emission line galaxies (93.3%) can be well separated by an empirical criterion
of . Meanwhile, a fainter sequence paralleled to the main population
of galaxies has been witnessed both in / and /
diagrams, which could be the population of luminous dwarf galaxies but
contaminated by the edge-on/highly inclined galaxies ().Comment: 19 pages, 14 figures, 2 MRT, accepted by ApJ
Nonlinear Decoherence in Quantum State Preparation of a Trapped Ion
We present a nonlinear decoherence model which models decoherence effect
caused by various decohereing sources in a quantum system through a nonlinear
coupling between the system and its environment, and apply it to investigating
decoherence in nonclassical motional states of a single trapped ion. We obtain
an exactly analytic solution of the model and find very good agreement with
experimental results for the population decay rate of a single trapped ion
observed in the NIST experiments by Meekhof and coworkers (D. M. Meekhof, {\it
et al.}, Phys. Rev. Lett. {\bf 76}, 1796 (1996)).Comment: 5 pages, Revte
Asymptomatic Atrial Fibrillation among Hospitalized Patients:clinical correlates and in-hospital outcomes in Improving Care for Cardiovascular Disease in China-Atrial Fibrillation
AIMS: The clinical correlates and outcomes of asymptomatic atrial fibrillation (AF) in hospitalized patients are largely unknown. We aimed to investigate the clinical correlates and in-hospital outcomes of asymptomatic AF in hospitalized Chinese patients.METHODS AND RESULTS: We conducted a cross-sectional registry study of inpatients with AF enrolled in the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation Project between February 2015 and December 2019. We investigated the clinical characteristics of asymptomatic AF and the association between the clinical correlates and the in-hospital outcomes of asymptomatic AF. Asymptomatic and symptomatic AF were defined according to the European Heart Rhythm Association score. Asymptomatic patients were more commonly males (56.3%) and had more comorbidities such as hypertension (57.4%), diabetes mellitus (18.6%), peripheral artery disease (PAD; 2.3%), coronary artery disease (55.5%), previous history of stroke/transient ischaemic attack (TIA; 17.9%), and myocardial infarction (MI; 5.4%); however, they had less prevalent heart failure (9.6%) or left ventricular ejection fractions ≤40% (7.3%). Asymptomatic patients were more often hospitalized with a non-AF diagnosis as the main diagnosis and were more commonly first diagnosed with AF (23.9%) and long-standing persistent/permanent AF (17.0%). The independent determinants of asymptomatic presentation were male sex, long-standing persistent AF/permanent AF, previous history of stroke/TIA, MI, PAD, and previous treatment with anti-platelet drugs. The incidence of in-hospital clinical events such as all-cause death, ischaemic stroke/TIA, and acute coronary syndrome (ACS) was higher in asymptomatic patients than in symptomatic patients, and asymptomatic clinical status was an independent risk factor for in-hospital all-cause death, ischaemic stroke/TIA, and ACS.CONCLUSION: Asymptomatic AF is common among hospitalized patients with AF. Asymptomatic clinical status is associated with male sex, comorbidities, and a higher risk of in-hospital outcomes. The adoption of effective management strategies for patients with AF should not be solely based on clinical symptoms.</p
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy
published_or_final_versio
23 MHz widely wavelength-tunable L-band dissipative soliton from an all-fiber Er-doped laser
Via careful choice of Er-doped fiber length in the cavity, a widely wavelength-tunable L-band dissipative soliton all-fiber Er-doped laser incorporating a L-band optimized polarizing fiber grating device is experimentally demonstrated. The laser delivers 15.38 ps dissipative soliton pulses centered at 1597.34 nm with 3 dB bandwidth of 34.6 nm under 622 mW pump power. The pulse repetition rate is 23 MHz. After using single mode fiber at external cavity, the pulse duration is compressed to 772 fs. With nonlinear polarization rotation-based intracavity comb filter, the central wavelength of the generated dissipative soliton can be tuned from 1567 nm to 1606 nm with a spectral tuning range of 39 nm, which, to the best of our knowledge, is the widest tuning range yet reported for a dissipative soliton fiber laser working in communication band
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