72 research outputs found
Beter laat dan nooit : over de noodzaak tot implementatie van antivirale therapie bij chronische virale hepatitis B en C
Ovaj rad pod nazivom Kineski emitivni turizam i utjecaj na Europsku uniju bavi se
gospodarskim, druÅ”tvenim, politiÄkim i turistiÄkim razvojem Kine te pokazuje turistiÄka kretanja
prema Europi. Gospodarska, i djelomiÄno sve otvorenija politika Narodne Republike Kine
znaÄajno doprinosi poveÄanju kineskom emitivnom turizmu. To se odnosi na meÄunarodni
turizam, receptivni turizam i sve veÄi emitivni turizam u Kini. PomoÄu pojednostavljenog ADS
(approved destination status) postupka, poveÄanja obrazovanja i prihoda u kuÄanstvima, te sve
viŔe slobodnog vremena kao i pravo na regulirani odmor, kineskom stanovniŔtvu se sve viŔe
omoguÄuje putovanje izvan granica svoje zemlje. Na temelju analize znanstvene literature,
socio-ekonomskih turistiÄkih podataka i ukljuÄivanja izvora iz znanstvenih Älanaka, u ovome se
radu prikazuju pokretaÄi turizma,razvoj, politika kao i bitne institucije turistiÄke industrije koje
sudjeluju u stvaranju turizma kao takvog
Beter laat dan nooit : over de noodzaak tot implementatie van antivirale therapie bij chronische virale hepatitis B en C
Association between a progesterone receptor mutation and hepatitis E sero-positivity in liver transplant recipients
Problem: We investigated if the PROGINS mutation increases the risk of hepatitis E virus (HEV) infection in liver transplant recipients. PROGINS was analyzed through KASP assay; HEV serologies assessed via enzyme-linked immunosorbent assay and multiplex cytokine assays were evaluated in plasma with the ProcartaPlex human immunoassay. Seventy liver transplant recipients were evaluated, of which 23 (33%) were HEV immunoglobuln G (IgG)-positive (HEV+). The frequency of PROGINS in the HEV+ group was 34%, compared with 14% in those that were HEV IgG negative (HEVā). Cytokine measurements in a sub-set of samples from HEV+/PROGINS+ individuals showed decreased plasma levels of monokine induced by gamma interferon, a proliferation-inducing ligand, and stem cell factor, as well as increased levels of eotaxin-3 and interleukin-31 compared with those HEVā/PROGINSā samples. Our findings suggest an association between the PROGINS mutation and seropositivity for HEV in liver transplant recipients with consequent distorted cytokine levels
Management and outcome of hepatocellular adenoma with massive bleeding at presentation
AIM To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma (HCA). METHODS This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage (grade II or III) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrastenhanced magnetic resonance imaging (MRI) or pathological findings from biopsy or resection of the HCA. Hemorrhage was diagnosed based on findings from computed tomography or MRI. Medical records were reviewed for demographic features, clinical presentation, tumor features, initial and subsequent management, short- and long-term complications and patient and lesion follow-up. RESULTS All patients were female (n = 23). Treatment in the acute phase consisted of embolization (n = 9, 39.1%), conservative therapy (n = 13, 56.5%), and other intervention (
Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy
A new hepatitis B virus variant selected during lamivudine treatment was detected, in which the methionine (rtM204) in the so-called YMDD motif in the C
Quantitative measurement of HBeAg in chronic hepatitis B: A comparison between a radioimmunoassay, a fluorescence ELISA and a chemiluminescence ELISA
Suppression of hepatitis B virus replication mediated by hepatitis A-induced cytokine production
The predictive value of Golgi Protein 73 in differentiating benign from malignant liver tumors
Introduction: In the work up of primary solid liver lesions it is essential to differentiate correctly between benign and malignant tumors, such as hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) respectively. A promising new marker to detect HCC is Golgi Protein 73 (GP73). Studies comparing patients with HCC and cirrhosis with normal controls suggested that GP73 is specific for patients with HCC; however, patients with other liver tumors were not included. We therefore studied the predictive value of GP73 in differentiating between solid benign and malignant liver tumors. Materials and Methods: This study included 264 patients: 88 patients with HCC, 88 with hepatocellular adenoma (HCA), and 88 with focal nodal hyperplasia (FNH). A blood sample was collected from each patient to measure GP73 levels using a quantitative ELISA assay and differences in outcome between subgroups were compared. The receiver operating characteristic (ROC) curve, sensitivity and specificity of GP73 were calculated and compared to alpha-fetoprotein (AFP) levels. Results: When comparing malignant and benign liver tumors the area under ROC was 0.701 and 0.912 for GP73 and AFP respectively. Test characteristics revealed a sensitivity of 60% for GP73 and 65% for AFP; in addition the specificity was 77% for GP73 and 96% for AFP. Conclusion: Although the literature suggests that GP73 is a valuable serum marker in patients with HCC, the serum concentration may also be increased in patients with solid benign liver tumors. Therefore, a GP73 assay is less suitable for discriminating between primary malignant and benign tumors of the liver
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