Effects of High-Frequency Proprioceptive Training on Single Stance Stability in Older Adults: Implications for Fall Prevention

Single-limb stance instability is a major risk factor for falls in older adults. Thus, improvement of stance stability could play an important role in fall prevention. This study aimed to determine whether high-frequency proprioceptive training (HPT) could significantly improve single stance stability (SSS) in older adults, by increasing proprioceptive control and optimizing the contribution of vision. Sixty-one subjects (30 men, 31 women) aged 65-85 years were investigated. The subjects were randomly assigned to three intervention groups, i.e., HPT, treadmill, and no intervention, stratifying by gender and proprioceptive control at baseline. Stability tests and HPT, consisting of 12 sessions (6 weeks), were performed with computerized postural stations. Pre-post analysis showed that HPT significantly improved SSS by increasing proprioceptive control (p<0.001) and postural control (p<0.01). The treadmill and no intervention groups did not show any significant change. The results showed that different levels of proprioceptive control may activate, inhibit, or minimize the stabilizing intervention of vision. Given that HPT significantly reduced ankle sprains and low back pain in professional athletes (previous study), we discuss the hypothesis that the risk of falls in older adults and the risk of recurrent injuries in athletes would have a common origin: lack of proprioceptive control consequent to reduced interaction with uneven ground. The findings suggest that HPT may be a powerful activator of refined proprioceptive control, which allows increased SSS, safer interaction with the ground, and mitigation of other risk factors

Brazil, Ethiopia, and New Zealand lead the way on climate-smart agriculture.

As countries around the world face urgent agricultural challenges, the concept of ?climate-smart? agriculture (CSA) has been put forward to achieve climate change adaptation, mitigation, and food security synergistically. A new report explores how three countries are using integrated policy approaches to CSA and offers insights for how other countries can build CSA into their policy mix. Brazil has invested in research to support sustainable intensification while creating legal and enforcement mechanisms to protect forest areas as a response to unrestrained agricultural expansion driven by market demand. Ethiopia initiated innovative participatory watershed development programs, in partnership with numerous international institutions, which helped smallholder farmers to rehabilitate marginal land and break out of a poverty cycle. New Zealand has removed agricultural subsidies while partnering on research and development with the private sector as a way to ensure efficiency and resilience in an agricultural sector influenced by climate change and international trade dynamics. To assemble an integrated set of national policies that fosters CSA, governments will need context-specific assessments, strong multi-stakeholder institutions, coordination frameworks, and multi-scale information systems. Governments can select from an array of policy instruments ranging from regulatory mechanisms and economic incentives to public investments and educational campaigns. Many existing national policy goals and public programs designed to increase agricultural production, improve livelihoods, and reduce environmental risks can become important pillars of a national CSA strategy. Countries have obvious interests in fostering an agriculture sector that is climate-resilient, provides national needs for food, fiber, and fuel, and supports farm livelihoods. However, the incentives for national-level action toward reducing global greenhouse gas (GHG) levels are less clear in the absence of serious and shared international commitment. Integrated national CSA policies will be encouraged by clear, consistent signals from multilateral agencies, global donors, and international conventions and trade agreements that promote agriculture as a pathway for poverty reduction and food security

A Diet Enriched in Docosahexanoic Acid Exacerbates Brain Parenchymal Extravasation of Apo B Lipoproteins Induced by Chronic Ingestion of Saturated Fats

Chronic ingestion of saturated fatty acids (SFAs) was previously shown to compromise blood-brain barrier integrity, leading to brain parenchymal extravasation of apolipoprotein B (apo B) lipoproteins enriched in amyloid beta. In contrast, diets enriched in mono- or polyunsaturated (PUFA) oils had no detrimental effect. Rather, n3 and n6 oils generally confer protection via suppression of inflammation. This study investigated in wild-type mice if a PUFA diet enriched in docosahexanoic acid (DHA) restored blood-brain barrier integrity and attenuated parenchymal apo B abundance induced by chronic ingestion of SFA. Cerebrovascular leakage of apo B was quantitated utilising immunofluorescent staining. The plasma concentration of brain-derived S100β was measured as a marker of cerebrovascular inflammation. In mice fed SFA for 3 months, provision thereafter of a DHA-enriched diet exacerbated parenchymal apo B retention, concomitant with a significant increase in plasma cholesterol. In contrast, provision of a low-fat diet following chronic SFA feeding had no effect on SFA-induced parenchymal apo B. The findings suggest that in a heightened state of cerebrovascular inflammation, the provision of unsaturated fatty acids may be detrimental, possibly as a consequence of a greater susceptibility for oxidation

The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults

IDENTIFIKASI HAMA PADA TANAMAN PADI INPARI 30 (Oriza sativa L) DI DESA PAPE KECAMATAN BAJAWA KABUPATEN NGADA

This study aims to determine and identify pests that attack Inpari 30 rice plants in Pape Village, Bajawa District, Ngada Regency, East Nusa Tenggara Province by making direct observations in the field. This research was carried out starting from February to May 2023. The research object was in the rice fields owned by farmers. This research was descriptive qualitative, namely observing and identifying 30 inpari rice pests that were seen during direct observation on 25 acres of farmer's land in Pape Village. Sampling by cluster sampling method Pest sampling technique is determined by saturated sampling method because all members of the pest population are used as samples. The results of observations in the field indicate that observations in the morning are the first detection of pests in the field. Types of pests include: False white pests, golden snails, grasshoppers, white stem borer (Scirpophaga innotata), green leafhoppers, brown planthoppers, stinging bugs (Leptocorixa acuta) and sparrows. Keywords: Identification, Pests, Diseases of Inpari 30 Rice Plants INTISARIPenelitian ini bertujuan untuk mengetahui dan mengidentifikasi hama yang menyerang tanaman padi Inpari 30 di Desa Pape Kecamatan Bajawa Kabupaten Ngada Provinsi Nusa tenggara Timur dengan melakukan pengamatan secara langsung di lapangan. Penelitian ini telah laksanakan terhitung mulai  Februari sampai dengan bulan Mei 2023. Obyek penelitian di lahan sawah  milik petani. Penelitian ini deskriptif kualitatif yakni mengamati dan mengidentifikasi jenis hama padi inpari 30 yang terlihat pada saat pengamatan langsung di lahan milik petani seluas 25 are di Desa Pape. Pengambilan sampel dengan metode cluster sampling teknik pengambilan sampel hama ditentukan dengan metode sampling jenuh karena semua anggota populasi hama digunakan sebagai sampel. Hasil pengamatan di lapangan menunjukkan bahwa pengamatan di pagi hari merupakan pendeteksi awal keberadaan hama di lapangan. Jenis hama yang diantaranya: Hama putih palsu, keong mas, belalang, penggerek batang putih (Scirpophaga innotata), wereng hijau, wereng coklat, walang sangit (Leptocorixa acuta) dan burung pipit. Kata kunci: Identifikasi, Hama, Penyakit Tanaman Padi Inpari 3

Comparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular risk

BACKGROUND: It is speculated that high saturated fat very low carbohydrate diets (VLCARB) have adverse effects on cardiovascular risk but evidence for this in controlled studies is lacking. The objective of this study was to compare, under isocaloric conditions, the effects of a VLCARB to 2 low saturated fat high carbohydrate diets on body composition and cardiovascular risk. METHODS: Eighty three subjects, 48 ± 8 y, total cholesterol 5.9 ± 1.0 mmol/L, BMI 33 ± 3 kg/m(2 )were randomly allocated to one of 3 isocaloric weight loss diets (6 MJ) for 8 weeks and on the same diets in energy balance for 4 weeks: Very Low Fat (VLF) (CHO:Fat:Protein; %SF = 70:10:20; 3%), High Unsaturated Fat (HUF) = (50:30:20; 6%), VLCARB (4:61:35; 20%) RESULTS: Percent fat mass loss was not different between diets VLCARB -4.5 ± 0.5, VLF-4.0 ± 0.5, HUF -4.4 ± 0.6 kg). Lean mass loss was 32-31% on VLCARB and VLF compared to HUF (21%) (P < 0.05). LDL-C increased significantly only on VLCARB by 7% (p < 0.001 compared with the other diets) but apoB was unchanged on this diet and HDL-C increased relative to the other 2 diets. Triacylglycerol was lowered by 0.73 ± 0.12 mmol/L on VLCARB compared to -0.15 ± 0.07 mmol/L on HUF and -0.06 ± 0.13 mmol/L on VLF (P < 0.001). Plasma homocysteine increased 6.6% only on VLCARB (P = 0.026). VLCARB lowered fasting insulin 33% compared to a 19% fall on HUF and no change on VLF (P < 0.001). The VLCARB meal also provoked significantly lower post prandial glucose and insulin responses than the VLF and HUF meals. All diets decreased fasting glucose, blood pressure and CRP (P < 0.05). CONCLUSION: Isocaloric VLCARB results in similar fat loss than diets low in saturated fat, but are more effective in improving triacylglycerols, HDL-C, fasting and post prandial glucose and insulin concentrations. VLCARB may be useful in the short-term management of subjects with insulin resistance and hypertriacylglycerolemia

Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases

Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam cell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial adhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the complement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal may be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and pharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide an update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and therapeutic options