Alien Registration- Malloch, Frank M. (Eastport, Washington County)

https://digitalmaine.com/alien_docs/1401/thumbnail.jp

A single session intervention (the Mini AFTERc) for fear of cancer recurrence : a feasibility study

Key Points • Aim was to test a single-session, telephone delivered intervention to reduce FCR in breast cancer patients. • 16 female breast cancer patients received the 30-minute, Mini-Adjustment to the Fear, Threat and Expectation of Recurrence (Mini-AFTERc) intervention. • Intervention implementation was feasible with cancer nurse specialists and fidelity was high. • Participants showed a significant decrease in recurrence fears at follow-up (effect size = 0.8; P = 0.03). • Preliminary results suggest the Mini-AFTERc is effective in reducing recurrence fears in breast cancer survivors.PostprintPeer reviewe

Evaluating the impact of pyrethroid insecticide resistance on reproductive fitness in Sitobion avenae

Resistance to insecticides used to control pests is an issue of increasing concern for agriculture. The grain aphid, Sitobion avenae, is a pest of cereals and grasses worldwide, and one of growing concern due to the evolution of resistance to certain insecticides. Resistance confers benefits to insects by enabling them to survive exposure to insecticide compounds; however, the mutations conferring resistance may also penalise the insect in pesticide-free environments due to fitness costs associated with the new phenotype. Here we tested the hypothesis of a reproductive penalty linked to the knockdown resistance mutation (kdr) to pyrethroid insecticides. The mutation occurs predominantly in a single SA3 clone. To date, only heterozygous-resistant forms (kdr-SR) have been detected in populations in Ireland and the UK, and this suggests that a fitness penalty may preclude the formation of both male and female heterozygous-resistant sexual forms. By designing an experiment which included a resistant and a non-resistant clone, we were able to simulate reduced daylight and temperature conditions which, in nature, trigger sexual reproduction and therefore study the responses of each clone. This allowed us to detect the switch from asexual females to sexual females and males and report on the conditions associated with the production of sexual forms. The results showed that both aphid clones were able to produce sexual forms with no difference in the onset of sexual reproduction, although reproductive strategies differed between clones. The later onset of male forms in the SA3 clone may decrease the likelihood of mating interactions to create fully resistant (kdr-RR) genotypes and this may constitute a fitness penalty due to pyrethroid resistance

Genomic resources for Myzus persicae: EST sequencing, SNP identification, and microarray design

<p>Abstract</p> <p>Background</p> <p>The green peach aphid, <it>Myzus persicae </it>(Sulzer), is a world-wide insect pest capable of infesting more than 40 plant families, including many crop species. However, despite the significant damage inflicted by <it>M. persicae </it>in agricultural systems through direct feeding damage and by its ability to transmit plant viruses, limited genomic information is available for this species.</p> <p>Results</p> <p>Sequencing of 16 <it>M. persicae </it>cDNA libraries generated 26,669 expressed sequence tags (ESTs). Aphids for library construction were raised on <it>Arabidopsis thaliana</it>, <it>Nicotiana benthamiana</it>, <it>Brassica oleracea, B. napus</it>, and <it>Physalis floridana </it>(with and without <it>Potato leafroll virus </it>infection). The <it>M. persicae </it>cDNA libraries include ones made from sexual and asexual whole aphids, guts, heads, and salivary glands. <it>In silico </it>comparison of cDNA libraries identified aphid genes with tissue-specific expression patterns, and gene expression that is induced by feeding on <it>Nicotiana benthamiana</it>. Furthermore, 2423 genes that are novel to science and potentially aphid-specific were identified. Comparison of cDNA data from three aphid lineages identified single nucleotide polymorphisms that can be used as genetic markers and, in some cases, may represent functional differences in the protein products. In particular, non-conservative amino acid substitutions in a highly expressed gut protease may be of adaptive significance for <it>M. persicae </it>feeding on different host plants. The Agilent eArray platform was used to design an <it>M. persicae </it>oligonucleotide microarray representing over 10,000 unique genes.</p> <p>Conclusion</p> <p>New genomic resources have been developed for <it>M. persicae</it>, an agriculturally important insect pest. These include previously unknown sequence data, a collection of expressed genes, molecular markers, and a DNA microarray that can be used to study aphid gene expression. These resources will help elucidate the adaptations that allow <it>M. persicae </it>to develop compatible interactions with its host plants, complementing ongoing work illuminating plant molecular responses to phloem-feeding insects.</p

Music and HCI

Music is an evolutionarily deep-rooted, abstract, real-time, complex, non-verbal, social activity. Consequently, interaction design in music can be a valuable source of challenges and new ideas for HCI. This workshop will reflect on the latest research in Music and HCI (Music Interaction for short), with the aim of strengthening the dialogue between the Music Interaction community and the wider HCI community. We will explore recent ideas from Music Interaction that may contribute new perspectives to general HCI practice, and conversely, recent HCI research in non-musical domains with implications for Music Interaction. We will also identify any concerns of Music Interaction that may require unique approaches. Contributors engaged in research in any area of Music Interaction or HCI who would like to contribute to a sustained widening of the dialogue between the distinctive concerns of the Music Interaction community and the wider HCI community will be welcome

National interest to global reform: patterns of reasoning in British foreign policy discourse

Discussion of the national interest often focuses on how Britain's influence can be maximized, rather than on the goals that influence serves. Yet what gives content to claims about the national interest is the means-ends reasoning which links interests to deeper goals. In ideal-typical terms, this can take two forms. The first, and more common, approach is conservative: it infers national interests and the goals they advance from existing policies and commitments. The second is reformist: it starts by specifying national goals and then asks how they are best advanced under particular conditions. New Labour's foreign policy discourse is notable for its explicit use of a reformist approach. Indeed, Gordon Brown's vision of a 'new global society' not only identifies global reform as a key means of fulfilling national goals, but also thereby extends the concept of the national interest well beyond a narrow concern with national security

Co-operation in Drug Treatment Services: Views of Offenders on Court Orders in Scotland

Accessing client perspectives about cooperation in substance misuse treatment offers important information to enhance services and improve drop-out rates. This article reports upon qualitative data from a localized study of service needs of offenders in Scotland who were undertaking community-based court orders. The views of 27 men and 2 women on their current and recent treatment offers rich insights into factors influencing their cooperation in treatment. In contradiction to the voluntaristic ideology of treatment services, their voices identify the criminal justice system as offering strong support in the completion of treatment programmes