Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. 1H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic.O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de 1H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos

Modification of kinetoplast DNA minicircle composition in pentamidine-resistant Leishmania1Nucleotide sequence data for L. donovani reported in this paper have been submitted to EMBL Nucleotide Sequence Database with the accession numbers: Y11397 (B), Y11398 (C), Y11399 (E), Y11400 (G), Y11401 (I), Y11402 (N).1

International audienc

Effects of Pentamidine on Polyamine Level and Biosynthesis in Wild-Type, Pentamidine-Treated, and Pentamidine-ResistantLeishmania

International audienc

Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

N-benzylethylenediamine derivatives have been prepared in good yields using methodology diferent than that described in the literature. ¹H and 13C NMR spectra were used to characterize those compounds. Nine new platinum(II) complexes, analogs of cisplatin and carboplatin, containing these ligands have been prepared and characterized. Preliminary in vitro tests against buccal human carcinoma cell lines (KB cells) showed that the complexes are cytotoxic