The IBIS soft gamma-ray sky after 1000 INTEGRAL orbits

We report here an all-sky soft gamma-ray source catalog based on IBIS observations performed during the first 1000 orbits of INTEGRAL. The database for the construction of the source list consists of all good quality data available from launch in 2002 up to the end of 2010. This corresponds to $\sim$110 Ms of scientific public observations with a concentrated coverage on the Galactic Plane and extragalactic deep exposures. This new catalog includes 939 sources above a 4.5 sigma significance threshold detected in the 17-100 keV energy band, of which 120 represent previously undiscovered soft gamma-ray emitters. The source positions are determined, mean fluxes are provided in two main energy bands, and are reported together with the overall source exposure. Indicative levels of variability are provided, and outburst times and durations are given for transient sources. Comparison is made with previous IBIS catalogs, and those from other similar missions.Comment: 65 pages, 9 figures, 2 tables, accepted for publication in ApJ Supplement

A Methodological Framework to Discover Pharmacogenomic Interactions Based on Random Forests

The identification of genomic alterations in tumor tissues, including somatic mutations, deletions, and gene amplifications, produces large amounts of data, which can be correlated with a diversity of therapeutic responses. We aimed to provide a methodological framework to discover pharmacogenomic interactions based on Random Forests. We matched two databases from the Cancer Cell Line Encyclopaedia (CCLE) project, and the Genomics of Drug Sensitivity in Cancer (GDSC) project. For a total of 648 shared cell lines, we considered 48,270 gene alterations from CCLE as input features and the area under the dose-response curve (AUC) for 265 drugs from GDSC as the outcomes. A three-step reduction to 501 alterations was performed, selecting known driver genes and excluding very frequent/infrequent alterations and redundant ones. For each model, we used the concordance correlation coefficient (CCC) for assessing the predictive performance, and permutation importance for assessing the contribution of each alteration. In a reasonable computational time (56 min), we identified 12 compounds whose response was at least fairly sensitive (CCC > 20) to the alteration profiles. Some diversities were found in the sets of influential alterations, providing clues to discover significant drug-gene interactions. The proposed methodological framework can be helpful for mining pharmacogenomic interactions

INTEGRAL high energy detection of the transient IGR J11321-5311

Context: The transient hard X-ray source IGR J11321-5311 was discovered by INTEGRAL on June 2005, during observations of the Crux spiral arm. To date, this is the only detection of the source to be reported by any X/gamma-ray mission. Aims: To characterize the behaviour and hence the nature of the source through temporal and spectral IBIS analysis. Methods: Detailed spectral and temporal analysis has been performed using standard INTEGRAL software OSA v.5.1. Results: To date, IGR J11321-5311 has been detected only once. It was active for about 3.5 hours, a short and bright flare lasting about 1.5 hours is evident in the IBIS light curve. It reached a peak flux of about 80 mCrab or 2.2x10E-9 erg cmE-2 sE-1 (20--300 keV),corresponding to a peak luminosity of 1.1x10E37 erg sE-1 (assuming a distance of 6.5 kpc). During the outburst, the source was detected with a significance of 18 sigma (20--300 keV) and 8 sigma (100--300 keV). The spectrum of the total outburst activity (17--300 keV) is best fitted by the sum of a power law (Gamma=0.55+/-0.18) plus a black body (kT=1.0{+0.2}_{-0.3} keV), with no evidence for a break up to 300 keV. A spectral analysis at Science Window level revealed an evident hardening of the spectrum through the outburst. The IBIS data were searched for pulsations with no positive result. Conclusions: The X-ray spectral shape and the flaring behaviour favour the hypothesis that IGR J11321-5311 is an Anomalous X-ray Pulsar, though a different nature can not be firmly rejected at the present stage.Comment: accepted for publication in A&A letter, 4 pages, 6 figure

Looking for blazars in a sample of unidentified high-energy emitting Fermi sources

Context. Based on their overwhelming dominance among associated Fermi γ-ray catalogue sources, it is expected that a large fraction of the unidentified Fermi objects are blazars. Through crossmatching between the positions of unidentified γ-ray sources from the First Fermi Catalog of γ-ray sources emitting above 10 GeV (1FHL) and the ROSAT and Swift/XRT catalogues of X-ray objects and between pointed XRT observations, a sample of 36 potential associations was found in previous works with less than 15 arcsec of positional offset. One-third of them have recently been classified; the remainder, though believed to belong to the blazar class, still lack spectroscopic classifications. Aims. We study the optical spectrum of the putative counterparts of these unidentified gamma-ray sources in order to find their redshifts and to determine their nature and main spectral characteristics. Methods. An observational campaign was carried out on the putative counterparts of 13 1FHL sources using medium-resolution optical spectroscopy from the Osservatorio Astronomico di Bologna in Loiano, Italy; the Telescopio Nazionale Galileo and the Nordic Optical Telescope, both in the Canary Islands, Spain; and the Observatorio Astronómico Nacional San Pedro Mártir in Baja California, Mexico. Results. We were able to classify 14 new objects based on their continuum shapes and spectral features. Conclusions. Twelve new blazars were found, along with one new quasar and one new narrow line Seyfert 1 (NLS1) to be potentially associated with the 1FHL sources of our sample. Redshifts or lower limits were obtained when possible alongside central black hole mass and luminosity estimates for the NLS1 and the quasar.Fil: Marchesini, Ezequiel Joaquín. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Masetti, Nicola. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Chavushyan, V.. Instituto Nacional de Astrofísica, Óptica y Electrónica; MéxicoFil: Cellone, Sergio Aldo. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Andruchow, Ileana. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Bassani, L.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Bazzano, A.. Istituto di Astrofisica e Planetologia Spaziali; ItaliaFil: Jiménez-Bailón, E.. Universidad Nacional Autónoma de México; MéxicoFil: Landi, R.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Malizia, A.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Palazzi, E.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Patiño Álvarez, V.. Instituto Nacional de Astrofísica, Óptica y Electrónica; MéxicoFil: Rodríguez Castillo, G. A.. Osservatorio Astronomico di Roma; ItaliaFil: Stephen, J. B.. Istituto di Astrofisica Spaziale e Fisica Cosmica di Bologna; ItaliaFil: Ubertini, P.. Istituto di Astrofisica e Planetologia Spaziali; Itali