Luminosity functions of Lyman-alpha emitters at z=6.5, and z=5.7: evidence against reionization at z=6

Lyman-alpha emission from galaxies should be suppressed completely or partially at redshifts beyond reionization. Without knowing the instrinsic properties of galaxies at z = 6.5, this attenuation is hard to infer in any one source, but can be infered from a comparison of luminosity functions of lyman-alpha emitters at redshifts just before and after reionization. We combine published surveys of widely varying depths and areas to construct luminosity functions at z=6.5 and 5.7, where the characteristic luminosity L_star and density phi_star are well constrained while the faint-end slope of the luminosity function is essentially unconstrained. Excellent consistency is seen in all but one published result. We then calculate the likelihood of obtaining the z=6.5 observations given the z=5.7 luminosity function with (A) no evolution and (B) an attenuation of a factor of three. Hypothesis (A) gives an acceptable likelihood while (B) does not. This indicates that the z=6.5 lyman-alpha lines are not strongly suppressed by a neutral intergalactic medium and that reionization was largely complete at z = 6.5.Comment: Submitted to Astrophysical Journal Letter

An Overdensity of Lyman-alpha Emitters at Redshift z=5.7 near the Hubble Ultra Deep Field

We have identified an obvious and strong large scale structure at redshift z=5.75 in a wide (31 by 33 arcminute) field, narrowband survey of the Chandra Deep Field South region. This structure is traced by 17 candidate Lyman alpha emitters, among which 12 are found in an 823nm filter (corresponding to Lyman alpha at z=5.77 +- 0.03) and 5 in an 815nm image (z=5.70 +- 0.03). The Lyman alpha emitters in both redshift bins are concentrated in one quadrant of the field. The Hubble Ultra Deep Field, Chandra Deep Field South, and GOODS-South fields all lie near the edge of this overdense region. Our results are consistent with reports of an overdensity in the UDF region at z=5.9. This structure is the highest redshift overdensity found so far.Comment: 12 pages, AASTeX. Submitted to ApJ Letters, and revised in response to referee's comment

Combining Information from Crosslinks and Monolinks in the Modeling of Protein Structures

Monolinks are produced in a chemical crosslinking mass spectrometry experiment and are more abundant than crosslinks. They convey residue exposure information, but so far have not been used in the modeling of protein structures. Here, we present the Monolink Depth Score (MoDS), for assessing structural models based on the depth of monolinked residues, corresponding to their distance to the nearest bulk water. Using simulated and reprocessed experimental data from the Proteomic Identification Database, we compare the performance of MoDS to MNXL, our previously developed score for assessing models based on crosslinking data. Our results show that MoDS can be used to effectively score models based on monolinks, and that a crosslink/monolink combined score (XLMO) leads to overall higher performance. The work strongly supports the use of monolink data in the context of integrative structure determination. We also present XLM-Tools, a program to assist in this effort, available at: https://github.com/Topf-Lab/XLM-Tools

Effects of Dust Geometry in Lyman Alpha Galaxies at z = 4.4

Equivalent widths (EWs) observed in high-redshift Lyman alpha galaxies could be stronger than the EW intrinsic to the stellar population if dust is present residing in clumps in the inter-stellar medium (ISM). In this scenario, continuum photons could be extinguished while the Lyman alpha photons would be resonantly scattered by the clumps, eventually escaping the galaxy. We investigate this radiative transfer scenario with a new sample of six Lyman alpha galaxy candidates in the GOODS CDF-S, selected at z = 4.4 with ground-based narrow-band imaging obtained at CTIO. Grism spectra from the HST PEARS survey confirm that three objects are at z = 4.4, and that another object contains an active galactic nuclei (AGN). If we assume the other five (non-AGN) objects are at z = 4.4, they have rest-frame EWs from 47 -- 190 A. We present results of stellar population studies of these objects, constraining their rest-frame UV with HST and their rest-frame optical with Spitzer. Out of the four objects which we analyzed, three objects were best-fit to contain stellar populations with ages on the order of 1 Myr and stellar masses from 3 - 10 x 10^8 solar masses, with dust in the amount of A_1200 = 0.9 - 1.8 residing in a quasi-homogeneous distribution. However, one object (with a rest EW ~ 150 A) was best fit by an 800 Myr, 6.6 x 10^9 solar mass stellar population with a smaller amount of dust (A_1200 = 0.4) attenuating the continuum only. In this object, the EW was enhanced ~ 50% due to this dust. This suggests that large EW Lyman alpha galaxies are a diverse population. Preferential extinction of the continuum in a clumpy ISM deserves further investigation as a possible cause of the overabundance of large-EW objects that have been seen in narrow-band surveys in recent years.Comment: Submitted to the Astrophysical Journal. 35 pages, 7 figures and 4 table

Asteroid Belts in Debris Disk Twins: VEGA and FOMALHAUT

Vega and Fomalhaut, are similar in terms of mass, ages, and global debris disk properties; therefore, they are often referred as "debris disk twins". We present Spitzer 10-35 um spectroscopic data centered at both stars, and identify warm, unresolved excess emission in the close vicinity of Vega for the first time. The properties of the warm excess in Vega are further characterized with ancillary photometry in the mid infrared and resolved images in the far-infrared and submillimeter wavelengths. The Vega warm excess shares many similar properties with the one found around Fomalhaut. The emission shortward of ~30 um from both warm components is well described as a blackbody emission of ~170 K. Interestingly, two other systems, eps Eri and HR 8799, also show such an unresolved warm dust using the same approach. These warm components may be analogous to the solar system's zodiacal dust cloud, but of far greater. The dust temperature and tentative detections in the submillimeter suggest the warm excess arises from dust associated with a planetesimal ring located near the water-frost line and presumably created by processes occurring at similar locations in other debris systems as well. We also review the properties of the 2 um hot excess around Vega and Fomalhaut, showing that the dust responsible for the hot excess is not spatially associated with the dust we detected in the warm belt. We suggest it may arise from hot nano grains trapped in the magnetic field of the star. Finally, the separation between the warm and cold belt is rather large with an orbital ratio >~10 in all four systems. In light of the current upper limits on the masses of planetary objects and the large gap, we discuss the possible implications for their underlying planetary architecture, and suggest that multiple, low-mass planets likely reside between the two belts in Vega and Fomalhaut.Comment: 14 pages, accepted for publication in Ap

Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications

Background. Recent data suggest trait-like neurocognitive impairments in bipolar disorder (BPD), with deficits about 1 S.D. below average, less severe than deficits noted in schizophrenia. The frequency of significant impairment in BPD is approximately 60%, with 40% of patients characterized as cognitively spared. This contrasts with a more homogeneous presentation in schizophrenia. It is not understood why some BPD patients develop deficits while others do not. Method. A total of 136 patients with BPD completed the MATRICS Consensus Cognitive Battery and data were entered into hierarchical cluster analyses to: (1) determine the optimal number of clusters (subgroups) that fit the sample; and (2) assign subjects to a specific cluster based on individual profiles. We then compared subgroups on several clinical factors and real-world community functioning. Results. Three distinct neurocognitive subgroups were found: (1) an intact group with performance comparable with healthy controls on all domains but with superior social cognition; (2) a selective impairment group with moderate deficits on processing speed, attention, verbal learning and social cognition and normal functioning in other domains; and (3) a global impairment group with severe deficits across all cognitive domains comparable with deficits in schizophrenia. Conclusions. These results suggest the presence of multiple cognitive subgroups in BPD with unique profiles and begin to address the relationships between these subgroups, several clinical factors and functional outcome. Next steps will include using these data to help guide future efforts to target these disabling symptoms with treatment

Periodic Peritoneal Dialysis in End Stage Renal Disease: Is it Still Relevant? A Single Center Study from India

Background: High cost of maintenance hemodialysis (HD) and continuous ambulatory peritoneal dialysis (PD) in India has made renal replacement therapy out of reach of many patients with end stage renal disease (ESRD). Repeated puncture PD although inferior to HD biochemically, is easily and freely available across Rajasthan, India, and is simple to perform, and does not require sophisticated machines, thus making it an attractive option for dialysis for ESRD. Aim: To analyze the outcomes of periodic PD in patients with ESRD requiring dialysis support. Subjects and Methods: A prospective study analyzing the data of patients who underwent PD between August 2010 and January 2013 in Sawai Man Singh Hospital, Jaipur, India was conducted. Patients were divided into three groups based on the time period between first and second session of PD. Detailed demographic and clinical data during the study period were collected along with PD related complications. The main outcome studied was technique survival 1 year post initiation of PD. Results: 234 patients received an initial session of PD, of which 174 had a good response and were included in the study. 19 patients received the second PD within 7 days of first (Group 1), 45 patients within 8–14 days (Group 2) and 110 patients within 15–21 days (Group 3). The overall 1 year technique survival was 68.4% (91/133), with a rate of 50% (5/10), 56.8% (21/37), and 75.6% (65/86) for Group 1, Group 2, and Group 3, respectively. The time duration between first and second PD proved to be reliable indicator of the subsequent response, with a technique survival rate significantly lower in Group 1 patients compared to Groups 2 and 3 (P = 0.04). Median dialysis free days were 11, 16 and 21 days in Group 1, Group 2, and Group 3, respectively. Peritonitis rate observed was 2.1% (49/2261) during the study period. Conclusion: Periodic PD is a simple, safe and cheap procedure, which can be considered as used as a palliative measure in terminal uremia in underprivileged areas.Keywords: Peritoneal dialysis, End stage renal disease, Renal replacement therap