Metallogenic implications of biotite chemical composition: Sample from Cu-Mo-Au mineralized granitoids of the Shah Jahan Batholith, NW Iran

Abstract Igneous biotite has been analyzed from three I-type calc-alkaline intrusives of the Shah Jahan Batholith in NW Iran, which host several Cu-Mo-Au prospects. The XMg (Mg/Mg+Fe) value of biotite is the most significant chemical factor and the relatively high value of XMg corresponds to relatively high oxidation states of magma (estimated fO2 is mostly 10−12.5 to 10−7.5 bars), which is in good agreement with their host intrusions' setting and related ore occurrences. Based on criteria of AlIV and AlVI values, all studied biotites are primary (AlVI = 0), and based on Altotal values (2.23–2.82 apfu) are in distinctive ranges of mineralized granitoid (Altotal=3.2 apfu). The maximum F content of biotite from the Shah Jahan intrusions is moderately higher than those from some other calc-alkaline intrusions related to Cu-Mo porphyries in the world, and in contrast, Cl content is relatively lower. It is likely a result of primary magmatic vs. secondary hydrothermal origin, as well as the Mg-rich characteristics of the biotite in Shah Jahan. XMg values do not correlate with F and Cl contents of biotite, suggesting that biotite records changes in the F/OH and Cl/OH ratios in coexisting melt/fluids. It is consistent with F-compatible and Cl-incompatible behavior during fractional crystallization of wet calc-alkaline I-type granitoid magma generated at subduction related arc settings. The fugacity ratios of (H2O/HF), (H2O/HCl) and (HF/HCl) magmatic solutions coexisting with biotite illustrate similar trends in the three intrusions, which can be due to parental magma sources and/or indicate occurrence of similar magmatic processes prior to or contemporaneous with exsolution of fluids from melt. The observed trends caused F-depletions and Cl-enrichments within developed magmatic-hydrothermal systems which are one of the essential characteristics of potential Cu-Mo-Au mineralized I-type granitoids

STABILITY AND ERROR OF THE NEW NUMERICAL SOLUTION OF FRACTIONAL RIESZ SPACE TELEGRAPH EQUATION WITH TIME DELAY

In this paper, we propose a numerical method for Riesz space fractional telegraph equation with time delay. The Riesz fractional telegraph equation is approximated with the interpolating polynomial P2. First a system of fractional differential equations are obtained from the telegraph equation with respect to the time variable. Then our numerical algorithm is proposed. The convergence order and stability of the fractional order algorithms are proved. Finally, some numerical examples are constructed to describe the usefulness and profitability of the numerical method. Numerical results show that the accuracy of order O(t3)

Efficacy of High Dose Vitamin C, Melatonin and Zinc in Iranian Patients with Acute Respiratory Syndrome due to Coronavirus Infection: A Pilot Randomized Trial

INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19. METHODS:  Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, q6hr), oral melatonin (6 mg, q6hr), and oral zinc sulfate (50 mg, q6hr) for 10 days. Patients were monitored for changes in hypoxemia and inflammatory markers. RESULTS: Both treatment modalities were effective to improve PaO2/FiO2 and oxygen saturation. However, there were no significant differences between 2 groups (P > 0.05). There were reductions in CRP, ESR, and LDH levels in both study groups, although not significant. No significant difference was noted in length of ICU stay between 2 groups (P = 0.3). CONCLUSION: Our study suggests that addition of vitamin C, melatonin, and zinc to standard care is not associated with considerable improvement in patients with severe Covid-19.&nbsp

Assessment of neuropsychiatric indicators in children and adolescents with primary brain tumors and other brain space occupying lesions before and after surgery

  Objective Cognitive abilities may be impaired due to brain lesions in children and adolescents. This study aimed to investigate neuropsychiatric indicators in children and adolescents with primary brain tumor and other brain space occupying lesions (SOL) before and after surgical procedure. Methods & materials the current study is a pre and post study which was conducted on 81 patients with brain space occupying lesions aged less than 18. Patients with metastatic brain tumors were excluded. The study was performed between 20 December 2016 to 20 December 2017 on patients hospitalized in neurosurgery ward of Imam Reza university hospital, Tabriz, Iran. Before and after surgical procedure, Digit span forward and backward Task (to assess working memory), Stroop task and Trail Making Task A & B (to assess attention) and Rey Osterrieth Complex Figure Test (to assess Visual Spatial Memory) were done. Then, scores of tests were compared with normal values as well as the post-surgery scores. Results the most prevalent type of space occupying brain lesion was medulloblastoma and the most common region of involvement was posterior fossa tumor. Scores of all tests after surgery comparing to before surgery were significantly improved (P<0.05). In assessment of Digit span forward and backward Task with standard scores, there was no significant difference among scores of patients before surgery with the standard value (P>0.05). Regarding scores of various stages of Rey Osterrieth Complex Figure Test, the  scores of immediate recall stage was significantly low (P<0.05). Among Trail Making Task A & B and stroop task, before surgery, just the Trail Making Task A & B was significantly increased (P<0.05). Scores of Trail Making Task A was significantly higher in patients with medulloblastoma and anatomically in left temporal tumors which indicate greater damage of attention field (P<0.05). In addition, in cerebellar tumor, scores of immediate recall stage of Rey Osterrieth Complex Figure Test was significantly lower (P<0.05). Conclusions Visuo-Spatial Memory and attention in pre-surgery assessments was significantly impaired comparing to general population (P<0.05). Working memory, Visuo-Spatial Memory and attention showed improvement comparing to pre-surgery. Deficits in attention domain was greater in medulloblastoma

A case of pulmonary mucormycosis with limited clinical signs and symptoms in a controlled diabetic patient

Pulmonary mucormycosis is an opportunistic fungal infection. It usually affects immunocompromisedpatients with poorly controlled blood glucose and ketoacidosis. The diagnosis of mucormycosis is veryhard, particularly in severely immunocompromised patients. Here we describe a case of pulmonarymucormycosis in a well controlled diabetic patient who had limited clinical signs and symptoms. Thepatient was unsuccessfully treated with amphotericin B and died. This report seems to be a rare case ofpulmonary mucormycosis in well controlled diabetes mellitus

Design of grip strength measuring system using FSR and flex sensors using SVM algorithm

This paper proposes a design of a complete system to identify weak grip strength that is caused by multiple factors like ageing, diseases, or accidents. This paper presents a grip measurement system that comprises of force sensing resistor and flex sensor to evaluate the condition of the hand. The system is tested by gripping a pencil and a cylindrical object using the glove, to determine the condition of the hand. Force sensitive resistor (FSR) evaluates the force applied by the different parts of the palm on the object being grasped. Flex sensor evaluates the bending of the fingers and thumb. The data from the sensors is then compared with existing data to evaluate the state of the hand. The data from the sensors is stored on the personal computer (PC) through serial communication. A model is trained using the data from the sensors, which determine if the grip strength of the user is weak or strong. The model is also trained to differentiate between two modes that are pen mode and object mode. The model achieved an accuracy of 90.8 percent using support vector machine (SVM) algorithm. This glove can be deployed in medical centers to assist in grip strength measurement

Effect of sensory stimulation on respiratory function of patients undergoing mechanical ventilation

Introduction: Improving the respiratory function of patients for weaning Mechanical Ventilation (MV) is one of the caring challenges in critical care settings. The aim of this study was to eamine the effect of sensory stimulation on respiratory function of patients with MV. Materials and Methods: This pilot study is a quasi-experimental study that performed on 30 patients undergoing MV which selected with available sampling in intensive care units in Kashan. After recording demographic parameters and physiologic variables, sensory stimulation program was performed for 25 minutes in the morning by companion of the patient. Then respiratory and physiologic parameters of patients were measured immediately and one hour after intervention. Results: Findings showed that mean age of patients were 57.1±19.5 years and mean of days for MV was 5.7±4.4 days. In the most of patients (66.6%) MV was used because of respiratory failure. Sensory stimulation was significantly increased respiratory rate, minute ventilation, heart rate, oxygen saturation and systolic blood pressure (P0.05). Notably, the respiratory and physiologic parameters were declined  one hour after the sensory stimulation. Conclusion:  Sensory stimulation could be use for driving respiratory center in patients undergoing MV but did not affect on weaning indices. We suggested more study to evaluation the sensory stimulation on preparation of patients with MV for weaning in a long tim

Improved solid phase extraction for selective and efficient quantification of sunset yellow in different food samples using a novel molecularly imprinted polymer reinforced by Fe3O4@UiO-66-NH2

The overuse of synthetic dyes in food products has gradually increased in recent years, resulting food safety and human health has become a global issue. An innovative design of a magnetic molecularly imprinted polymer (Fe3O4@UiO-66-NH2@MIP) for efficient, fast, and selective determination of sunset yellow (SY) from different food products was described in this study. The absorption properties of Fe3O4@UiO-66-NH2@MIP were elucidated by adsorption kinetics, isotherms, reusability, and selectivity experiments. Because of the incorporation of porous Fe3O4@UiO-66-NH2 nanocomposite into molecularly imprinted polymer an efficient nanosorbent with a short equilibrium time, a high adsorption capacity, and a good imprinting factor was finally obtained. The porous Fe3O4@UiO-66-NH2@MIP are also used for quantification of the SY. Under optimal conditions, good linearity (R2 0.9964) in the range of 1.0�120 mg L�1 and a low limit of detection (0.41 mg L�1) was observed with satisfactory recoveries (92.50�106.1) and excellent reusability (RSD � 6.6 after 12 cycles)

Association between ear lobe crease and cerebrovascularv accidents

Introduction: Cerebrovascular accidents (CVA) are the third and second common cause of deathand morbidity in the world, respectively. Since high levels of serum lipids and atherosclerosis are onethe risk factors of CVA, and also there are some reports about relation between atherosclerosis andearlobe crease (ELC), the present study was performed to verify any association between ELC andCVA.Materials and Methods: This study was designed as a case-control study. 55 patients with CVA(case group) and 55 patients without CVA (control group) were selected, and then presence of ELCand serum levels of cholesterol, LDL, HDL were measured in both control and case groups.Results: The prevalence of ELC in CVA patients was more than without CVA (%74.1 vs. %26.8-p<0.001). Mean level of Cholesterol and LDL were more in patients with CVA than without CVA(p<0.001). Also, mean level of HDL in CVA group was less than control group (p<0.001). Mean levelof cholesterol and LDL were more and mean level of HDL was less in patients with ELC than patientswithout ELC (p<0.001)Conclusion: The prevalence of ELC in patients with CVA is more than in patients without CVA(OR: 7.81). Mean level of serum lipids in these patients were more than patients without CVA. CVAin patients with ELC is 7.81 times more common than without ELC. In due attention to highprevalence of ELC in patients with CVA, it seems ELC must be evaluated as a risk factor