From black holes to flux throats: polarization can resolve the singularity

Supersymmetry-breaking is a key ingredient for string theory models to be phenomenologically viable. We review the strong analogy in the physics and the methods used for describing non-supersymmetric flux vacua and non-supersymmetric black holes in string theory. We also show how the polarized state could be the key to describing a well-behaved back-reaction of anti-branes in flux backgrounds, shedding a new light on a recent debate in the literature.Comment: 5 pages, slightly extended contribution to the proceedings of the 21st European String Workshop: "The String Theory Universe" in Leuven, 7-11 Sept 201

Observations on fluxes near anti-branes

We revisit necessary conditions for gluing local (anti-)D3 throats into flux throats with opposite charge. These consistency conditions typically reveal singularities in the three-form fluxes whose meaning is being debated. In this note we prove, under well-motivated assumptions, that unphysical singularities can potentially be avoided when the anti-branes polarise into spherical NS5 branes with a specific radius. If a consistent solution can then indeed be found, our analysis seems to suggests a rather large correction to the radius of the polarization sphere compared to the probe result. We furthermore comment on the gluing conditions at finite temperature and point out that one specific assumption of a recent no-go theorem can be broken if anti-branes are indeed to polarise into spherical NS5 branes at zero temperature.Comment: 17 pages, 2 figures, v2: error corrected and text extende

Hyperparameter-free losses for model-based monocular reconstruction

This work proposes novel hyperparameter-free losses for single view 3D reconstruction with morphable models (3DMM). We dispense with the hyperparameters used in other works by exploiting geometry, so that the shape of the object and the camera pose are jointly optimized in a sole term expression. This simplification reduces the optimization time and its complexity. Moreover, we propose a novel implicit regularization technique based on random virtual projections that does not require additional 2D or 3D annotations. Our experiments suggest that minimizing a shape reprojection error together with the proposed implicit regularization is especially suitable for applications that require precise alignment between geometry and image spaces, such as augmented reality. We evaluate our losses on a large scale dataset with 3D ground truth and publish our implementations to facilitate reproducibility and public benchmarking in this field.Peer ReviewedPostprint (author's final draft

Research and in situ conservation of owl monkeys enhances environmental law enforcement at the Colombian-Peruvian border

This study reports on impacts of illegal trade in owl monkeys (Aotus nancymaae, A. vociferans) for the biomedical research market in the Colombian-Peruvian Amazonian border. Through freedom of information requests and interviews with hunters we found that 912 owl monkeys, including A. nancymaae captured in Peru, were trapped over a 3-month period in 2012 to supply a malaria research facility based in Leticia, Colombia, which had trapping permits for the use of only 800 A. vociferans annually yet experimentation took place using A. nancymaae. High levels of extraction in Peru have had population-level impacts with significantly lower densities of Aotus spp. (3-24individuals/km2) compared to Colombian sites with low hunting pressure (26-44individuals/km2). Post-experimental release of this species in Colombian territory has created a new distribution whose status and impacts on resident populations of A. vociferans remain unknown. The trapping method has also had environmental impact, with loss of over 65,000 trees (including sleeping sites), annually. As Aotus species are registered under the Convention of International Trade in Endangered Species of Wild Fauna and Flora (CITES) Appendix II, international trade requires official permission and evidence that extraction does not impact wild populations. However, no official records exist and CITES legislation has failed, due principally to a lack of appropriate monitoring by national authorities responsible for compliance. Of further concern is that we had previously documented and reported the illegal trade to the appropriate governmental authorities yet still no action was taken-as demonstrated by the continuing trade in 2013. Enforcement eventually occurred when a non-governmental organization initiated legal action against organizations responsible. A successful second instance ruling by the Colombian State's Council in 2013 revoked trapping permits. Using the trade in owl monkeys as a case study we consider implementation, compliance, and enforcement of CITES in the border area to identify mechanisms to improve enforcement of environmental legislation. Am. J. Primatol. 76:658-669, 2014. © 2014 Wiley Periodicals, Inc

The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation.

The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis virus (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c+CD11b+CD8alpha- DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8alpha- DC activation correlated with reduced IFN-gamma expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC

Identify. Quantify. Predict. Why immunologists should widely use molecular imaging for Coronavirus Disease 2019

Molecular imaging using PET/CT or PET/MRI has evolved from an experimental imaging modality at its inception in 1972 to an integral component of diagnostic procedures in oncology, and, to lesser extent, in cardiology and neurology, by successfully offerin

Hybrid Bayesian Networks Using Mixtures of Truncated Basis Functions

This paper introduces MoTBFs, an R package for manipulating mixtures of truncated basis functions. This class of functions allows the representation of joint probability distributions involving discrete and continuous variables simultaneously, and includes mixtures of truncated exponentials and mixtures of polynomials as special cases. The package implements functions for learning the parameters of univariate, multivariate, and conditional distributions, and provides support for parameter learning in Bayesian networks with both discrete and continuous variables. Probabilistic inference using forward sampling is also implemented. Part of the functionality of the MoTBFs package relies on the bnlearn package, which includes functions for learning the structure of a Bayesian network from a data set. Leveraging this functionality, the MoTBFs package supports learning of MoTBF-based Bayesian networks over hybrid domains. We give a brief introduction to the methodological context and algorithms implemented in the package. An extensive illustrative example is used to describe the package, its functionality, and its usage

Duration of Star Formation in Galactic Giant Molecular Clouds. I. The Great Nebula in Carina

We present a novel infrared spectral energy distribution (SED) modeling methodology that uses likelihood-based weighting of the model fitting results to construct probabilistic Hertzsprung–Russell diagrams (pHRD) for X-ray-identified, intermediate-mass (2–8 M⊙), pre-main-sequence young stellar populations. This methodology is designed specifically for application to young stellar populations suffering strong, differential extinction (ΔA_V > 10 mag), typical of Galactic massive star-forming regions. We pilot this technique in the Carina Nebula Complex (CNC) by modeling the 1–8 μm SEDs of 2269 likely stellar members that exhibit no excess emission from circumstellar dust disks at 4.5 μm or shorter wavelengths. A subset of ~100 intermediate-mass stars in the lightly obscured Trumpler 14 and 16 clusters have available spectroscopic T_(eff), measured from the Gaia-ESO survey. We correctly identify the stellar temperature in 85% of cases, and the aggregate pHRD for all sources returns the same peak in the stellar age distribution as obtained using the spectroscopic T_(eff). The SED model parameter distributions of stellar mass and evolutionary age reveal significant variation in the duration of star formation among four large-scale stellar overdensities within the CNC and a large distributed stellar population. Star formation began ~10 Myr ago and continues to the present day, with the star formation rate peaking ≾3 Myr ago when the massive Trumpler 14 and 16 clusters formed. We make public the set of 100,000 SED models generated from standard pre-main-sequence evolutionary tracks and our custom software package for generating pHRDs and mass–age distributions from the SED fitting results

Physical Limits on Raman Scattering: The Critical Role of Pump and Signal Co-design

We present a rigorous method for deriving limits on Raman scattering in structured media. We exploit this framework to constrain the maximum Raman signal resulting from a planewave incident on two experimentally relevant systems, consisting of either a single Raman molecule in the vicinity of a structured medium or a designable Raman medium (a distribution of Raman molecules). Results pertaining to metallic and dielectric structures illustrate the efficacy of structural optimization and the importance of accounting and co-designing for the nonlinear interplay between pump and signal fields. In particular, we show that treating the pump-focusing and signal-extraction processes separately, as has been done in prior works, leads to highly unrealistic predictions of achievable enhancements. The formulation could readily find applications in guiding further improvements on surface-enhanced Raman scattering (SERS) sensitivity and Raman-assisted lasing.Comment: 9 pages, 4 figure