Osteochondral Lesions of the Ankle Treated with Bone Marrow Concentrate with Hyaluronan and Fibrin: A Single-Centre Study.

Osteochondral defects of the ankle (OCD) are being increasingly identified as a clinically significant consequence of injury to the ankle, with the potential to lead to osteoarthritis if left untreated. The aim of this retrospective cohort study was to evaluate a single-stage treatment of OCD, based on bone marrow aspirate (BMA) centrifuged to produce bone marrow concentrate (BMC). In a dual syringe, the concentrate was mixed with thrombin in one syringe, whereas hyaluronan and fibrinogen were mixed in a second syringe. The two mixtures were then injected and combined into the prepared defect. Clinical outcome and quality of life scores (MOXFQ and EQ-5D) were collected at baseline and yearly thereafter. Multilevel models were used to analyse the pattern of scores over time. Ninety-four patients were treated between 2015 and 2020. The means of each of the three components of the MOXFQ significantly improved between baseline and 1 year (p < 0.001 for each component), with no further change from year 1 to year 3. The EQ-5D index also improved significantly from baseline to 1 year, with no evidence for further change. Our results strongly indicate that this BMC treatment is safe for, and well tolerated by, patients with OCD of the ankle as both primary treatment and those who have failed primary treatment. This technique provides a safe, efficacious alternative to currently employed cartilage repair techniques, with favourable outcomes and a low complication rate at 36 months

Measurements of 181Ta(n,2n)180Ta reaction cross-section at the neutron energy of 14.78 MeV

The cross-section of the 181Ta(n,2n)180Ta reaction has been measured with respect to the 197Au(n,2n)196Au monitor reaction at the incident neutron energy of 14.78± 0.20 MeV, using neutron activation analysis and off-line γ-ray spectrometric technique. The present measurement has been done at the energy where discrepant measured results are available in the EXFOR data library. The result has been compared with evaluated data libraries JEFF-3.3 and ENDF/B-VII.1. The present result has also been supported by theoretical predictions of nuclear model code TALYS1.8 and TALYS-1.9. The uncertainty and the correlations among the measured cross-section has been studied using co-variance analysis

Measurements of 181Ta(n,2n)180Ta reaction cross-section at the neutron energy of 14.78 MeV

The cross-section of the 181Ta(n,2n)180Ta reaction has been measured with respect to the 197Au(n,2n)196Au monitor reaction at the incident neutron energy of 14.78± 0.20 MeV, using neutron activation analysis and off-line -ray spectrometric technique. The present measurement has been done at the energy where discrepant measured results are available in the EXFOR data library. The result has been compared with evaluated data libraries JEFF-3.3 and ENDF/B-VII.1. The present result has also been supported by theoretical predictions of nuclear model code TALYS1.8 and TALYS-1.9. The uncertainty and the correlations among the measured cross-section has been studied using co-variance analysis

Measurement of (n,) reaction cross section of W-186-isotope at neutron energy of 20.02±0.58 MeV

The cross-section of 186W(n,)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

The cross-section of 186W(n,γ)187W reaction has been measured at an average neutron energy of 20.02±0.58 MeV by using activation technique. The 27Al(n,α)24Na and 115In(n,n´)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

Measurement of (n,γ) reaction cross section of 186W-isotope at neutron energy of 20.02±0.58 MeV

392-396The cross-section of 186W(n,&gamma;)187W reaction has been measured at an average neutron energy of 20.02&plusmn;0.58 MeV by using activation technique. The 27Al(n,&alpha;)24Na and 115In(n,n&acute;)115mIn reactions have been used for absolute neutron flux measurement. Theoretically the reaction cross-sections have been calculated by using the TALYS-1.9 code. The results from the present work and the EXFOR based literature data have been compared with the evaluated data and calculated data from TALYS-1.9 code

Aptamer-based radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of epithelial tumors

In the continuous search for earlier diagnosis and improved therapeutic modalities against cancer, based on our constantly increasing knowledge of cancer biology, aptamers hold the promise to expand on current antibody success, but overcoming some of the problems faced with antibodies as therapeutic or delivery agents in cancer. However, as the first aptamer reached the market as an inhibitor against angiogenesis for the treatment of macular degeneration, aptamers have found only limited applications or interest in oncology, and even less as radiopharmaceuticals for diagnostic imaging and targeted radiotherapy of tumours. Yet, the chemistry for the labelling of aptamers and the options to alter their pharmacokinetic properties, to make them suitable for use as radiopharmaceuticals is now available and recent advances in their development can demonstrate that these molecules would make them ideal delivery vehicles for the development of targeted radiopharmaceuticals that could deliver their radiation load with accuracy to the tumour site, offering improved therapeutic properties and reduced side effects

Oxidation of benzoin catalyzed by oxovanadium (IV) schiff base complexes

BACKGROUND: The oxidative transformation of benzoin to benzil has been accomplished by the use of a wide variety of reagents or catalysts and different reaction procedures. The conventional oxidizing agents yielded mainly benzaldehyde or/and benzoic acid and only a trace amount of benzil. The limits of practical utilization of these reagents involves the use of stoichiometric amounts of corrosive acids or toxic metallic reagents, which in turn produce undesirable waste materials and required high reaction temperatures. In recent years, vanadium complexes have attracted much attention for their potential utility as catalysts for various types of reactions. RESULTS: Active and selective catalytic systems of new unsymmetrical oxovanadium(IV) Schiff base complexes for the oxidation of benzoin is reported. The Schiff base ligands are derived between 2-aminoethanol and 2-hydroxy-1- naphthaldehyde (H2L1) or 3-ethoxy salicylaldehyde (H2L3); and 2-aminophenol and 3-ethoxysalicylaldehyde (H2L2) or 2-hydroxy-1-naphthaldehyde (H2L4). The unsymmetrical Schiff bases behave as tridentate dibasic ONO donor ligands. Reaction of these Schiff base ligands with oxovanadyl sulphate afforded the mononuclear oxovanadium(IV) complexes (VIVOLx.H2O), which are characterized by various physico-chemical techniques. The catalytic oxidation activities of these complexes for benzoin were evaluated using H2O2 as an oxidant. The best reaction conditions are obtained by considering the effect of solvent, reaction time and temperature. Under the optimized reaction conditions, VOL4 catalyst showed high conversion (>99%) with excellent selectivity to benzil (~100%) in a shorter reaction time compared to the other catalysts considered. CONCLUSION: Four tridentate ONO type Schiff base ligands were synthesized. Complexation of these ligands with vanadyl(IV) sulphate leads to the formation of new oxovanadium(IV) complexes of type VIVOL.H2O. Elemental analyses and spectral data of the free ligands and their oxovanadium(IV) complexes were found to be in good agreement with their structures, indicating high purity of all the compounds. Oxovanadium complexes were screened for the oxidation of benzoin to benzil using H2O2 as oxidant. The effect of time, solvent and temperature were optimized to obtain maximum yield. The catalytic activity results demonstrate that these catalytic systems are both highly active and selective for the oxidation of benzoin under mild reaction conditions.Web of Scienc

High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects

ABSTRACT

Dangers of using the edges of the Brillouin zone

International audienceIn solid-state physics, including photonics and wherever periodic lattice structures occur, it is essential to establish the fundamental features associated with wave propagation through the lattice: This is achieved using Bloch waves, the reciprocal lattice, and the reduction, using periodicity, to consider the irreducible Brillouin zone. A general approach, although widely accepted as not being perfectly legitimate, is to plot the dispersion relations around the edges of the Brillouin zone. We show definitively that this can be dangerous and that an important mode of practical significance is missed if this is done in too cavalier a fashion: This missing mode is illustrated for the design of endoscopes based on spring-mass (discrete) periodic structures and photonic crystals