521 research outputs found

    Recent Advances in the Genetics of Orthodontics

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    Mandibular Deviation and Unilateral Posterior Crossbite Treated with Intraoral Vertical Ramus Osteotomy and Sagittal Split Ramus Osteotomy

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    Adult patients with severe mandibular asymmetry are often treated with a combination of surgery and orthodontic treatment to improve facial esthetics and occlusion. Intraoral vertical ramus osteotomy is a useful surgical procedure for mandibular setback in patients with mandibular prognathism or mandibular asymmetry. A 17-year-old woman presented with a Class III malocclusion with facial asymmetry and a unilateral posterior crossbite. The patient was treated orthodontically with edgewise appliances and surgically with intraoral vertical ramus osteotomy and sagittal split ramus osteotomy. The combined surgical-orthodontic treatment resulted in facial symmetry and optimal occlusion

    A Unique Case of Primary Failure of Tooth Eruption with Mandibular Deformity

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    Primary failure of tooth eruption, which is extremely rare, has serious consequences and several possible causative factors. Teeth in the posterior quadrants of the upper and lower jaw are preferentially affected and when it occurs it usually results in an open bite extending from anterior to posterior. We report the case of a 29-year-old female patient who presented with primary failure of tooth eruption and mandibular deformity. The patient, who had no family history of tooth eruption failure, presented with impactions of the mandibular left molars. We discuss the clinical and radiographic features of this patient and describe the limitations of treatment for patients with eruption failure

    Superconducting Gap Structure of kappa-(BEDT-TTF)2Cu(NCS)2 Probed by Thermal Conductivity Tensor

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    The thermal conductivity of organic superconductor kappa-(BEDT-TTF)2Cu(NCS)2 (Tc =10.4 K) has been studied in a magnetic field rotating within the 2D superconducting planes with high alignment precision. At low temperatures (T < 0.5 K), a clear fourfold symmetry in the angular variation, which is characteristic of a d-wave superconducting gap with nodes along the directions rotated 45 degrees relative to the b and c axes of the crystal, was resolved. The determined nodal structure is inconsistent with recent theoretical predictions of superconductivity induced by the antiferromagnetic spin fluctuation.Comment: 5 pages, 4 figures, to be published in Phys. Rev. Let

    Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping

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    To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F2 populations generated from a BKS.Cg-m+/+Leprdb and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F2 populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes

    In Search of a Binding Agent: Nano-Scale Evidence of Preferential Carbon Associations with Poorly-Crystalline Mineral Phases in Physically-Stable, Clay-Sized Aggregates

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    Mechanisms of protecting soil carbon (C) are still poorly understood despite growing needs to predict and manage the changes in soil C or organic matter (OM) under anticipated climate change. A fundamental question is how the submicron-scale interaction between OM and soil minerals, especially poorly-crystalline phases, affects soil physical aggregation and C stabilization. Nano-sized composites rich in OM and poorly-crystalline mineral phases were presumed to account for high aggregate stability in the Andisol we previously studied. Here we searched for these nanocomposites within a sonication-resistant aggregate using scanning transmission X-ray microscopy (STXM) and near-edge X-ray absorption fine structure (NEXAFS) as well as electron microscopy (SEM, TEM). Specifically, we hypothesized that nanometer-scale spatial distribution of OM is controlled by poorly-crystalline minerals as both co-exist as physically-stable nanocomposites. After maximum dispersion of the cultivated Andisol A-horizon sample in water, one aggregate (a few p.m in diameter) was isolated from 0.2-2 mu m size fraction which accounted for 44-47% of total C and N and 50% of poorly-crystalline minerals in bulk soil. This fraction as well as 2 mu m size fractions, implying high abundance of the nanocomposites in the smaller fractions. The isolated aggregate showed a mosaic of two distinctive regions. Smooth surface regions showed low adsorption intensity of carbon K-edge photon energy (284-290 eV) with well-crystalline mineralogy, whereas rough surface regions had features indicative of the nanocomposites: aggregated nanostructure, high C intensity, X-ray amorphous mineral phase, and the dominance of Si, O, Al, and Fe based on SEM/EDX and TEM/EDX. Carbon functional group chemistry assessed by NEXAFS showed the dominance of amide and carboxyl C over aromatic and aliphatic C with some variation among the four rough surface regions. Together with C and N isotopic patterns among the size fractions (relatively low C:N ratio, high N-15 natural abundance, and more positive Delta C-14 of the <2 mu m fractions), our results provided the direct evidence of preferential binding of microbially-altered, potentially-labile C with poorly-crystalline mineral phases at submicron scale. The role of the nanocomposite inferred from this study may help to bridge the knowledge gap between physical aggregation process and biogeochemical reactions taking place within the soil physical structure
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